A case of multiple brain metastases of uterine leiomyosarcoma with a literature review

Yamada, So; Yamada, Shoko M.; Nakaguchi, Hiroshi; Murakami, Mineko; Hoya, Katsumi; Matsuno, Akira

doi:10.1016/j.suronc.2011.04.001

Cited by 22 publications

(23 citation statements)

References 15 publications

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“…The most common sites of uterine LMS metastasis are the lung, pelvis, and vagina (Rose et al, 1989 Mar 1, Mayerhofer et al, 1999 Aug), but brain metastasis is rare. To the best of our knowledge, only case reports of uterine LMS metastasis to the brain are available (Wroński et al, 1994 Aug, Honeybul and Ha, 2009 Mar, Yamada et al, 2011 Dec). Yamada et al reviewed in their case report that there had been 21 such cases (Yamada et al, 2011 Dec).…”

Section: Discussionmentioning

confidence: 99%

“…Brain metastasis of uterine leiomyosarcoma (LMS) is rare (Wroński et al, 1994 Aug, Honeybul and Ha, 2009 Mar, Yamada et al, 2011 Dec, Rose et al, 1989 Mar 1, Fleming et al, 1984 Oct). Several case reports suggest a resection of brain metastases of uterine LMS could result in longer survival, for which controlling systemic disease is a prerequisite (Wroński et al, 1994 Aug, Honeybul and Ha, 2009 Mar, Yamada et al, 2011 Dec, Gadducci et al, 1996 Jul).…”

Section: Introductionmentioning

confidence: 99%

“…Several case reports suggest a resection of brain metastases of uterine LMS could result in longer survival, for which controlling systemic disease is a prerequisite (Wroński et al, 1994 Aug, Honeybul and Ha, 2009 Mar, Yamada et al, 2011 Dec, Gadducci et al, 1996 Jul). However, adjuvant therapies after brain surgery have not been established.…”

Section: Introductionmentioning

confidence: 99%

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Pazopanib-mediated long-term disease stabilization after resection of a uterine leiomyosarcoma metastasis to the brain: A case report

Inoue

Taniguchi

Tomogane

et al. 2016

Gynecologic Oncology Reports

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A 48-year-old woman underwent a total abdominal hysterectomy after preoperative diagnosis of multiple uterine leiomyomas. The histopathological diagnosis was leiomyosarcoma (LMS). After 47 months, multiple lung metastases were detected and resected. The patient was also diagnosed with pelvic bone metastasis and received six cycles of adjuvant chemotherapy with gemcitabine plus docetaxel and local radiation therapy to control the pain. Seventy-seven months from the initial diagnosis, she had a headache and developed left hemiparesis and aphasia. Imaging studies detected a solitary brain metastasis in the right frontal lobe. The patient underwent a craniotomy and resection of the lesion, which was a confirmed metastasis from uterine LMS by histopathology. One month after the craniotomy, the patient experienced lower abdominal pain, and a pelvic metastasis was detected. She was prescribed oral pazopanib (800 mg per day). For twelve months, she remained asymptomatic, but gradually, pelvic pain increased due to pelvic mass growth. After 14 months of pazopanib treatment, pazopanib was discontinued. To date, for 18 months after the brain surgery, she is alive with disease, and the brain metastasis has not recurred.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pazopanib-mediated long-term disease stabilization after resection of a uterine leiomyosarcoma metastasis to the brain: A case report

Inoue

Taniguchi

Tomogane

et al. 2016

Gynecologic Oncology Reports

View full text Add to dashboard Cite

show abstract

“…ULMS has high metastatic potential and 5-year survival rates vary from 0 to 73 % in the literature [10]. Distant metastatic spread of ULMS has been described in lung [11], abdomen, soft tissue, and brain [12]. Less common metastatic sites include the breast [13] and bone [14].…”

Section: Discussionmentioning

confidence: 99%

Extensively Metastatic Vaginal Stump Leiomyosarcoma after Total Hysterectomy: A Rare Presentation—A Case Report with Review of Literature

Singhal

Jain

Saxena

et al. 2015

Indian J Gynecol Oncolog

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The incidence of leiomyosarcoma in uterine leiomyomas is estimated to be between 0.13 and 0.29 % [1]. However, the exact incidence of leiomyosarcoma in uteri removed with a pre-operative diagnosis of benign uterine leiomyomas has not been previously reported. In our study, we describe a case of a 58-year-old female who underwent total hysterectomy 10 years back for uterine leiomyoma and now presented to us with complaints of multiple body swellings over abdomen, arms, neck, scalp, and proptosis. On computed tomography, it was seen that there was a mass in abdomen arising from vaginal stump involving bladder, rectum with skin, muscle, omental, lung, liver, adrenal, and retroperitoneal metastases. Excisional biopsy from a parietal wall swelling and punch biopsy from the vaginal stump were taken. The final histopathological report confirmed it to be leiomyosarcoma with metastases all over the body. Combination chemotherapy of gemcitabine and docetaxel was given to patient. Patient responded to treatment on a 6 month follow-up.

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“…1 It shows early metastasis primarily to the lungs, peritoneal cavity, bones, pelvic and para-aortic lymph nodes.…”

Section: Introductionmentioning

confidence: 99%

Uterine leiomyosarcoma metastasizing to multiple sites: a rare presentation

Handa

Kundu

Mehra

et al. 2014

Int J Reprod Contracept Obstet Gynecol

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A case of multiple brain metastases of uterine leiomyosarcoma with a literature review

Cited by 22 publications

References 15 publications

Pazopanib-mediated long-term disease stabilization after resection of a uterine leiomyosarcoma metastasis to the brain: A case report

Pazopanib-mediated long-term disease stabilization after resection of a uterine leiomyosarcoma metastasis to the brain: A case report

Extensively Metastatic Vaginal Stump Leiomyosarcoma after Total Hysterectomy: A Rare Presentation—A Case Report with Review of Literature

Uterine leiomyosarcoma metastasizing to multiple sites: a rare presentation

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