A Case of Metastatic Bladder Cancer in Both Lungs Treated with Korean Medicine Therapy Alone

Lee, Dong-Hyun; Kim, Sung‐Su; Seong, Shin; Woo, Chang-Ryoul; Han, Jae-Bok

doi:10.1159/000365884

Cited by 15 publications

(9 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dietary intakes of flavonol and lignans, multifunctional compounds of plants, have been presented to reduce bladder cancer risk (4). Lee et al, have demonstrated the therapeutic efficacy of herbal medicines in a 74-year-old Korean patient with metastatic bladder cancer, where his pulmonary metastasis was diminished following his herbal treatment (5).…”

Section: Accumulation Of Cytosol Ros and Calcium Signalling Hyperfomentioning

confidence: 99%

Hyperforin Induces Apoptosis Through Extrinsic/Intrinsic Pathways and Inhibits NF-ĸB-modulated Survival and Invasion Potential in Bladder Cancer

Liu

Lin

Hsieh

et al. 2019

In Vivo

View full text Add to dashboard Cite

Background/Aim: Muscle-invasive bladder cancer (MIBC) has long been recognized as a difficult to treat cancer type, thus a new treatment strategy is needed. The major purpose of the present study was to verify the anticancer effect of hyperforin and the mechanism through which it affects tumor cell growth and invasion in bladder cancer in vitro. Materials and Methods: Bladder cancer TSGH-8301 cells were treated with different concentrations of hyperforin for different durations of time. The changes in cell viability, production of calcium and reactive oxygen species (ROS), and anti-apoptotic signaling were evaluated using MTT assay, flow cytometry, and western blot analysis. The effect of hyperforin on the expression of nuclear factor-kappaB (NF-ĸB) p65 (Ser276), tumor progression-associated proteins, as well as on cell invasion was investigated using western blotting and cell invasion assay, respectively. Results: Hyperforin significantly induces apoptosis, extrinsic/intrinsic apoptotic signaling,

show abstract

Section: Accumulation Of Cytosol Ros and Calcium Signalling Hyperfomentioning

confidence: 99%

Hyperforin Induces Apoptosis Through Extrinsic/Intrinsic Pathways and Inhibits NF-ĸB-modulated Survival and Invasion Potential in Bladder Cancer

Liu

Lin

Hsieh

et al. 2019

In Vivo

View full text Add to dashboard Cite

show abstract

“…YZSJD is a formula contributing to regulate the disorder of human homeostasis, in which the ethanol extract of Scutellaria Barbata D. Don has been revealed to suppress the activation of several colorectal cancer-associated pathways ( 39 ). Cremastra appendiculata tuber , the other type of Cremastrae Pseudobulbus is reported to decrease the metastatic nodules and relieve symptoms of metastatic bladder cancer in the lungs with several herbs ( 40 ). In addition, Yangzheng Xiaoji, a similar formula in which the exact composition is unknown, has been demonstrated to inhibit angiogenesis, thus exhibiting an anticancer effect ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Yangzheng Sanjie Decoction-containing serum mediated by microRNA-7 on cell proliferation and apoptosis in gastric cancer

Chen

Nie

et al. 2018

Oncol Lett

View full text Add to dashboard Cite

Gastric cancer (GC) is one of the most common types of cancer and a leading cause of cancer-associated mortality. MicroRNAs (miRNAs/miRs) are demonstrated to function as oncomiRs or tumor-suppressor-miRs in GC. miR-7 has been identified to be a tumor suppressor of GC by targeting epidermal growth factor receptor (EGFR). In our previous study, Yangzheng Sanjie Decoction (YZSJD), a traditional Chinese formula, was identified to be effective in alleviating the symptoms and even postponing turnover of precancerous lesions. To elucidate the mechanism of YZSJD, the present study evaluated the effects of YZSJD of the GC MKN-45 cell line and investigated the underlying molecular mechanisms using YZSJD-containing serum (YCS). The expression of miR-7 in GC, normal and adjacent tissue samples was examined. The results demonstrated that YCS inhibited proliferation by inducing cell cycle arrest at the S phase, and significantly induced apoptosis compared with the control group. miR-7 was significantly downregulated in GC tissues compared with the matched ones. Using reverse transcription-quantitative polymerase chain reaction and western blot analysis, the expression of miR-7 was inversely associated with EGFR. This indicates that YCS inhibits proliferation and induces apoptosis of GC cells mediated by miR-7 targeting EGFR, which may be one of the mechanisms whereby YZSJD exerts its effects on GC.

show abstract

“…Upon processing ginseng with heat at 120°C, most peaks of ginsenosides Rb1, Rb2, Rc, and Rd disappeared and the presence of less polar ginsenosides 20(S,R)-Rg3, Rk1, and Rg5 was newly detected [ 8 ]. Lee et al [ 9 ] reported about recurrence control and metastasis decrease in lymph nodes in patients with metastatic breast cancer as well as decrease in the metastatic part of the lung of patients with metastatic bladder infection after ingestion of HAD S and administration of Soram nebulizer solution. Spiam HC is composed of P. ginseng , S. miltiorrhiza , S. officinalis , and A. capillaris Thunberg.…”

Section: Discussionmentioning

confidence: 99%

Stage IV Wilms Tumor Treated by Korean Medicine, Hyperthermia and Thymosin-α1: A Case Report

et al. 2016

Self Cite

View full text Add to dashboard Cite

Introduction: Wilms tumor is one of general solid cancers that occur in children, which carries a death rate of 7-8 in a million. The cure rate of Wilms tumor in the recent 30 years has dramatically been improved, but a proper remedy is still not prepared enough in terms of application in tumor therapy upon recurrence after radiotherapy, surgery and chemotherapy. We present an integrative medical remedy - hyperthermia and thymosin-α₁ treatment focused on herbal remedy - since there have been cases in which this remedy contributed to remission in the liver-transferred part in the 4th phase of Wilms tumor and stable maintenance of metastatic lung lesion. Case Presentation: Our patient, a female Korean mongoloid outpatient, was treated from October 25, 2014, to July 22, 2015. The herbal remedy consisted of 8 ml inhalation of Soram nebulizer solution q.d., Soramdan S 8 g p.o., Hangamdan S 1 g p.o., t.i.d., Cheongjangtang 10-30 ml, and Spiam HC 8 g p.o. The integrative medical therapy was done with hyperthermia therapy (oncothermia) and 1.6 mg of thymosin-α₁ treatment (Zadaxin) i.m. According to the CT result on July 15th, 2015, the liver metastasis was not seen anymore, while the lung metastasis was maintained stably without tumor progress. Conclusions: Accompanying integrative medical therapy with herbal remedy in the treatment of Wilms tumor showing progress patterns after surgery and chemotherapy can be meaningful as a new remedy.

show abstract

A Case of Metastatic Bladder Cancer in Both Lungs Treated with Korean Medicine Therapy Alone

Cited by 15 publications

References 15 publications

Hyperforin Induces Apoptosis Through Extrinsic/Intrinsic Pathways and Inhibits NF-ĸB-modulated Survival and Invasion Potential in Bladder Cancer

Hyperforin Induces Apoptosis Through Extrinsic/Intrinsic Pathways and Inhibits NF-ĸB-modulated Survival and Invasion Potential in Bladder Cancer

Effects of Yangzheng Sanjie Decoction-containing serum mediated by microRNA-7 on cell proliferation and apoptosis in gastric cancer

Stage IV Wilms Tumor Treated by Korean Medicine, Hyperthermia and Thymosin-α1: A Case Report

Contact Info

Product

Resources

About