A case of massive porocarcinoma

Abstract

A 53-year-old Cambodian woman presented with nodular masses on the right arm suggestive of a sarcoma-type malignancy. The masses were excised and identified as multiple benign eccrine poromas. The patient re-presented after two years with large relapsed tumours and axillary lymph node involvement. A forequarter amputation was undertaken. Histology confirmed the diagnosis of a porocarcinoma, which was likely to be due to malignant transformation of the original poromas. The size and multiplicity of the tumours represents a highly unusual presentation of these rare eccrine neoplasms.

Porocarcinoma of the left arm: A report of a rare skin cancer case and literature review

“…To date, only 15 cases occurring on the arms (including the current case) have been documented in the literature. 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 Clinically, PC presents as a slow‐growing, red, dome‐shaped skin nodule with a shiny surface or as a wart‐like plaque, papule, or polyp that is sometimes painful and ulcerative. The lesion size can range from <1 cm to up to 10 cm.…”

“…Given its rare occurrence, most of the literature has reported single clinical cases and a few case series, and there are currently no uniform international guidelines for these patients. 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31…”

“…The location on the arms represents only 4.8% of PC common sites (only 14 cases have been registered at the moment). 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 …”

Eccrine Porocarcinoma with Zosteriform Metastasis

“…Squamous differentiation of clear cells, sarcomatoid change, and melanin pigment can be identified. Histopathologically speaking, the main differential diagnoses are squamous cell carcinoma, hidradenocarcinoma, and extracutaneous metastatic carcinomas [10,11].…”

Sentinel lymph node biopsy in porocarcinoma: A case reports

“…EPC is a rare neoplasm arising from the intra-epidermal ductal portion of the eccrine sweat gland and represents approximately 0.005% of all cases of malignant epithelial neoplasms [ [6] , [7] , [8] , 12 ].…”