A case of kerion celsi caused by<i>Microsporum gypseum</i>in a boy following dermatoplasty for a scalp wound from a road accident

Zhang, Ruifeng; Ran, Yuping; Dai, Yong; Zhang, Hao; Yao, Lu

doi:10.3109/13693786.2010.503196

Cited by 18 publications

(28 citation statements)

References 6 publications

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“…2). 23–25 Our results were similar to those in other Tunisian studies, noting that living conditions, large family size and close contact with other infected children at school, physical contact with animals and playing outside may facilitate fungal transmission 8,11,12,26 …”

Section: Discussionsupporting

confidence: 88%

“…The prevalence data we obtained from our study were different with results as reported from many other regions of the world. In Tunisia, the incidence of inflammatory TC is varied from 2.3% to 13% 1,11–16 . This value was lower than that observed in Spain (18.2%) and Saudi Arabia (19.8%) 17 .…”

Section: Discussionmentioning

confidence: 60%

“…This acute painful inflammatory boggy mass with alopecia on the scalp, often with crusting and purulent discharge, is called kerion celsi and it is the result of an intense hypersensitivity reaction from a dermatophytic infection 10 . This condition is rare, with only few articles in the literature and most of them are case reports 7,10–12 . In our study, 121 cases of inflammatory TC were reviewed between a total 881 TC (13.73%) and a total 96251 consultants (0.125%) collected through 12 years.…”

Section: Discussionmentioning

confidence: 99%

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Inflammatory Tinea capitis: a 12‐year study and a review of the literature

Zarâa

Hawilo

Aounallah

et al. 2012

Mycoses

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Inflammatory Tinea capitis (TC) is a rare form of TC. The aim of this study was to review epidemiological, clinical and mycological profile of inflammatory TC. We present a retrospective study (1999-2010), enrolled all the cases of inflammatory TC observed at a referral hospital in the northern Tunisia. One hundred and twenty-one patients with inflammatory TC, 83 male patients (68.6%) and 38 female patients (31.4%) were enrolled. The mean age was about 8 years. A majority of TC (71.9%) were in patients lesser than 10 years of age. Positive family history and contact with animals were noted in seven and 35 cases respectively. Direct examination was positive in 110 cases (59 ectothrix, 51 endothrix) and positive cultures were obtained in 105 patients (49 Trichophyton violaceum, 31 Microsporum canis, 13 Trichophyton interdigitale complex, 12 Trichophyton verrucosum). Systemic treatment was carried out in 115 patients with griseofulvin, in one with terbinafine. A complete recovery was noted in 88 cases; and persistent alopecia in 28 cases. The inflammatory TC is rare, but more common in rural families. The disease mostly affected male genders (68.6%) and T. violaceum remains the common pathogen of inflammatory TC in northern Tunisia.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

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Inflammatory Tinea capitis: a 12‐year study and a review of the literature

Zarâa

Hawilo

Aounallah

et al. 2012

Mycoses

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“…The same resistance mutation combination has been described also in cystic fibrosis patients, recently [35]. In general, the development of azole resistance in Aspergillus fumigatus in cystic fibrosis patients due to TR34/L98H and other cyp51 A mutations has been published [36]–[38]. However, this group of patients is different to our severely immunocompromised hematological patients' population, since culture of fungal diagnostic from respiratory samples is mostly positive in cystic fibrosis patients; the amount of DNA is not the limiting factor investigating cyp 51A mutations from isolates.…”

Section: Discussionmentioning

confidence: 66%

Incidence of Cyp51 A Key Mutations in Aspergillus fumigatus—A Study on Primary Clinical Samples of Immunocompromised Patients in the Period of 1995–2013

et al. 2014

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As the incidence of azole resistance in Aspergillus fumigatus is rising and the diagnosis of invasive aspergillosis (IA) in immunocompromised patients is rarely based on positive culture yield, we screened our Aspergillus DNA sample collection for the occurrence of azole resistance mediating cyp51 A key mutations. Using two established, a modified and a novel polymerase chain reaction (PCR) assays followed by DNA sequence analysis to detect the most frequent mutations in the A. fumigatus cyp51 A gene conferring azole resistance (TR34 (tandem repeat), L98H and M220 alterations). We analyzed two itraconazole and voriconazole and two multi-azole resistant clinical isolates and screened 181 DNA aliquots derived from clinical samples (blood, bronchoalveolar lavage (BAL), biopsies, cerebrospinal fluid (CSF)) of 155 immunocompromised patients of our Aspergillus DNA sample collection, previously tested positive for Aspergillus DNA and collected between 1995 and 2013. Using a novel PCR assay for the detection of the cyp51 A 46 bp tandem repeat (TR46) directly from clinical samples, we found the alteration in a TR46/Y121F/T289A positive clinical isolate. Fifty stored DNA aliquots from clinical samples were TR46 negative. DNA sequence analysis revealed a single L98H mutation in 2010, two times the L98H alteration combined with TR34 in 2011 and 2012 and a so far unknown N90K mutation in 1998. In addition, four clinical isolates were tested positive for the TR34/L98H combination in the year 2012. We consider our assay of epidemiological relevance to detect A. fumigatus azole resistance in culture-negative clinical samples of immunocompromised patients; a prospective study is ongoing.

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“…Примером может служить случай импетиго-подобных высыпаний на лице у 3-летней девочки, вызванный телеоморфой Trichophyton interdigitale, успешно леченный итраконазолом (пероральный прием) с местными аппликациями 1% крема нафти-фина и шампуня с кетоконазолом [21]. Китайские дерматологи применяли нафтифин у месячного ре-бенка при керион Цельса волосистой части головы, вызванного Microsporum gypseum (системно приме-нялся тербинафин) [22].…”

Section: клиническая дерматология и венерология 2 2015unclassified

Rationale for selection of a topical antimycotic agent

Касихина¹

2015

Klin. dermatol. venerol.

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В статье представлены данные отечественных и зарубежных рандомизированных клинических исследований, посвященных эффективности нафтифина гидрохлорида (Экзодерил) при наружной терапии онихомикозов и дерматофитий гладкой кожи. На примере нафтифина гидрохлорида обозначены критерии подбора топического антимикотика при онихомикозе, обусловленные выраженностью противовоспалительного, кератолитического и антимикробного действия. Широкий спектр противогрибкового действия нафтифина подтверждается доказанным in vitro отсутствием резистентности возбудителей к препарату. Ключевые слова: дерматофитии, онихомикоз, наружная терапия, нафтифина гидрохлорид (Экзодерил), клинические и микробиологические исследования.The article presents the data of domestic and foreign randomized clinical trials on the efficacy of naftifine hydrochloride (Exoderil) in topical treatment of onychomycoses and dermatophytoses of the smooth skin. The criteria for selection of a topical antimycotic agent for onychomycosis that are based on the intensity of anti-keratolytic and antimicrobial action are described on the example of naftifine hydrochloride. A wide range of the antifungal activity of naftifine is confirmed by the in vitro proven absence of resistance of pathogens to the drug.

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A case of kerion celsi caused byMicrosporum gypseumin a boy following dermatoplasty for a scalp wound from a road accident

Cited by 18 publications

References 6 publications

Inflammatory Tinea capitis: a 12‐year study and a review of the literature

Inflammatory Tinea capitis: a 12‐year study and a review of the literature

Incidence of Cyp51 A Key Mutations in Aspergillus fumigatus—A Study on Primary Clinical Samples of Immunocompromised Patients in the Period of 1995–2013

Rationale for selection of a topical antimycotic agent

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