A case of indeterminate dendritic cell tumor presenting with leonine facies

Oh, Chang Wug; Ivan, Doina; Curry, Jonathan L.; Ellis, Rachel; Gerber, Howard; Duvic, Madeleine; Torres‐Cabala, Carlos A.

doi:10.1111/cup.12611

Cited by 13 publications

(10 citation statements)

References 22 publications

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“…Including our report, the literature describes 79 cases of IDCN (Table , Tables S1 and S2, and Appendix S1, Supporting Information), mostly as skin lesions (91%) and almost always in the form of papules and/or nodules involving the head, chest, back, axillae, groins and/or extremities; but sparing the palms and soles. Plaques or patches were described in only 5 cases . Two reported cases showed extensive facial involvement in the form of leonine facies .…”

Section: Discussionmentioning

confidence: 99%

“…Plaques or patches were described in only 5 cases. [4][5][6][7][8] Two reported cases showed extensive facial involvement in the form of leonine facies. 5,6 Congenital disease was documented in 2 newborns with solitary skin lesions on the forehead 9 or sacral region.…”

Section: Discussionmentioning

confidence: 99%

“…[4][5][6][7][8] Two reported cases showed extensive facial involvement in the form of leonine facies. 5,6 Congenital disease was documented in 2 newborns with solitary skin lesions on the forehead 9 or sacral region. 10 Only 5 cases were reported as primary lymph node disease without skin lesions, 11-14 while 3 additional patients showed lymph node involvement in the setting of multilesional skin disease.…”

Section: Discussionmentioning

confidence: 99%

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Indeterminate dendritic cell neoplasm of the skin: A 2‐case report and review of the literature

et al. 2017

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Indeterminate dendritic cell neoplasm (IDCN) is an exceedingly rare and mostly cutaneous histiocytosis, frequently associated with other hematopoietic malignancies. We report 2 cases of multilesional cutaneous IDCN. A 55-year-old male with no associated malignancy and complete response to ultraviolet phototherapy; and a 72-year-old male with chronic myelomonocytic leukemia (CMML). Both cases showed histiocytoid cytology, positivity for CD1a and no expression of langerin or BRAF . With our patients, the literature describes 79 cases of IDCNs, including 65 (82%) with only skin involvement, 7 cases (9%) with involvement of skin and a second site, 5 cases (6%) involving lymph nodes only, 1 splenic lesion and 1 systemic disease. Seventeen cases (22%) were associated with other hematopoietic malignancies, most commonly CMML (6 cases), follicular lymphoma (4 cases) and acute myeloid leukemia (3 cases). All IDCNs associated with myeloid malignancies were limited to the skin, while most cases associated with lymphoma were limited to lymph nodes. Reported responses of cutaneous lesions to ultraviolet phototherapy are encouraging, while systemic chemotherapy is appropriate for clinically aggressive cases and treatment of associated malignancies. Recognition of the clinico-morphologic spectrum of IDCNs should prevent misdiagnoses and prompt investigation of possible associated neoplasms.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Indeterminate dendritic cell neoplasm of the skin: A 2‐case report and review of the literature

et al. 2017

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“…While the extent of involvement may be variable, most reported cases of ICH described lesions that were smaller in size and fewer in number compared to the extensive, confluent and lumpy nature of the lesions in our patient. Apart from one other case report of indeterminate dendritic cell tumor in whom the presentation was that of a leonine facies, our patient's florid, and disfiguring clinical presentation has not been reported in ICH before. Instead, the extensive involvement of the face and generalized lesions on the trunk and limbs had prompted an initial suspicion of progressive nodular histiocytosis (PNH).…”

Section: Discussionmentioning

confidence: 50%

Indeterminate cell histiocytosis in a Chinese patient with progressive and extensive nodular lesions and mixed indeterminate cell and macrophage‐monocyte lineage

et al. 2018

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Indeterminate cell histiocytosis (ICH) is an extremely rare cutaneous neoplastic disorder. It has the immunophenotypic features of both Langerhans and non-Langerhans cell histiocytosis. We report here a case of a healthy young Chinese woman who presented with disfiguring, thick, infiltrated cutaneous nodules on the face, trunk and extremities which appeared progressively over a period of 4 years. No systemic involvement has been detected so far. Results of a skin biopsy showed diffuse dermal infiltration of histiocytoid cells with indented nuclei and positive staining for S100 and CD1a and negativity for CD207 (langerin). Admixed within were some CD68-positive foamy histiocytes and multinucleated giant cells with focal expression of CD163. Although the clinical presentation is more typical of progressive nodular histiocytosis, the histology and immunoprofile is consistent with ICH. Our report adds to the limited case reports in the current literature of ICH in the Chinese population.

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“…The current case is of particular interest because of its unique morphology and cutaneous presentation. Leonine facies are rare (2), and are more frequent in association with lepromatous leprosy (3), cutaneous T-cell lymphomas (4, 5), lichen myxoedematosus (LM) (6), and pachydermoperiostosis (7) ( Table I). Clinical and histopathological features can help to differentiate these conditions from ICH (8)(9)(10)(11).…”

Section: Case Reportmentioning

confidence: 99%

Indeterminate Cell Histiocytosis Presenting with Leonine Facies

Chen¹,

Nguyen²

2018

Acta Derm Venerol

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A case of indeterminate dendritic cell tumor presenting with leonine facies

Abstract: This case illustrates the variegated clinical presentation of indeterminate cell tumor and the necessity of appropriate immunohistochemical workup for its diagnosis.

Cited by 13 publications

References 22 publications

Indeterminate dendritic cell neoplasm of the skin: A 2‐case report and review of the literature

Indeterminate dendritic cell neoplasm of the skin: A 2‐case report and review of the literature

Indeterminate cell histiocytosis in a Chinese patient with progressive and extensive nodular lesions and mixed indeterminate cell and macrophage‐monocyte lineage

Indeterminate Cell Histiocytosis Presenting with Leonine Facies

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