Indeterminate Cell Histiocytosis Presenting with Leonine Facies

Chen, Cheng; Nguyen, Giang Huong

doi:10.2340/00015555-2866

Cited by 6 publications

(5 citation statements)

References 10 publications

(14 reference statements)

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“…We then selected and included in the study 78 papers, describing 108 patients (Figure 1). 5,8,9,12,32–106 From two case series, we included only some of the described patients, as indicated in Table 1 12,48 …”

Section: Resultsmentioning

confidence: 99%

Indeterminate cell histiocytosis: A systematic review of the literature with a comprehensive revision of clinical, histopathological, and molecular features

Zanella

Berti

Bonometti

2023

Acad Dermatol Venereol

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Indeterminate cell histiocytosis (ICH) is a very rare histiocytic disorder, primarily involving the skin. It affects more frequently adults, often presenting with a generalized papular eruption, and needs to be differentiated from other neoplastic, paraneoplastic, and infectious diseases through clinical and histological examination. The knowledge on ICH is limited to case reports and small series. Thus, the lack of larger multicentric studies has prevented recognizing and addressing the specific clinical need of the entity. In this systematic review, we comprehensively analysed the medical literature describing histologically‐confirmed cases of ICH and divided the patients into epidemiologically and clinically different groups. We demonstrate that ICH in adulthood is strongly associated with the development of haematological (and especially myeloid) neoplasms. In this subset of patients, we identify blastic morphology of neoplastic cells as a novel independent prognostic factor and an early histopathological predictor of an associated myeloid neoplasm. Moreover, we highlight that even though ICH may also present in childhood, these patients often show indolent behaviour. Genetically, ICH emerges as a heterogeneous condition. While patients with associated myeloid neoplasms are enriched in pERK pathway gene mutations, in others a specific ETV3::NCOA2 rearrangement is described. We finally reviewe the nosology of ICH since its first description, its possible cell of origin, and summarize the therapeutic options reported for each different clinical subgroup. With this work, we hope to foster studies on rare cutaneous histiocytosis and their comprehensive multidisciplinary characterization.

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Section: Resultsmentioning

confidence: 99%

Indeterminate cell histiocytosis: A systematic review of the literature with a comprehensive revision of clinical, histopathological, and molecular features

Zanella

Berti

Bonometti

2023

Acad Dermatol Venereol

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“…HSCT PR 9 [ 30 ] Fournier (2011) Female 65 MF No No MTX Complete clinical remission after 2 months of treatment, relapse during dose reduction:SD with RR 5 [ 5 ] Bettington (2011) Male 40 MF No FL, lymph nodes Multiple regimens to treat FL: CVP,CVP-R and CHOP 4 months after diagnosed with IDCT, he died due to the development of end-stage liver disease, which limited the treatment. :DOC 4 [ 21 ] Chen (2018) Male 31 MF N0 No MTX, no response, transfer to isotretinoin and thalidomide Improvement on skin, under follow up: SD 48 [ 17 ] Zhou (2019) Male 37 MF Yes No No Corticosteroids, vinca alkaloids, CTX Utilizing a range of treatments, yet constantly experiencing remission and relapse within 5 years. SD with RR 60 [ 16 ] Fischer (2021) Female 55 MF No No Thalidomide 6 months: lesion progress:PD ...…”

Section: Literature Reviewmentioning

confidence: 99%

“…We reviewed the current examples of IDCT with cutaneous symptoms treated with chemotherapy medications to assess the efficacy and safety of chemotherapy drugs 1,5,[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] (Table 1). We found that remission and relapse occurred in 8 out of 26 chemotherapy-treated patients reported to date.…”

Section: Treatmentmentioning

confidence: 99%

Recurrent Chemotherapy Treated Indeterminate Dendritic Cell Tumor: Case Report and Literature Review

Li,

Zhang,

Xiong

2023

CCID

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Indeterminate dendritic cell tumor (IDCT) is an extremely uncommon histiocytic and dendritic neoplasms subtype that presents as single or multiple papules. There is currently no standard method for diagnosis and treatment, and the selection of therapeutic approaches is mainly based on successful examples of folk medicine. We describe a case of a pathology diagnosed indeterminate dendritic cell tumor, which shows the presence of CD1a, S100, and CD68, but lack langerin. She was treated with multi-chemotherapy regimens used to treat lymphoma and gained good results short term but was easy to recur. In addition, we reviewed the literature on the effectiveness and safety of chemotherapy in IDCT patients.

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“…Facial lesions can predominate, mimicking the leonine facies or benign cephalic histiocytosis. Other possible differential diagnoses that should be included are LCH, generalized eruptive histiocytosis, sarcoidosis, Rosai‐Dorfman disease, or juvenile xanthogranuloma, 4 entities that can be easily ruled out by histological examination.…”

Section: Figurementioning

confidence: 99%

Erythematous papules on face and arms of an elderly woman: a case of indeterminate cell histiocytosis

et al. 2021

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Indeterminate Cell Histiocytosis Presenting with Leonine Facies

Cited by 6 publications

References 10 publications

Indeterminate cell histiocytosis: A systematic review of the literature with a comprehensive revision of clinical, histopathological, and molecular features

Indeterminate cell histiocytosis: A systematic review of the literature with a comprehensive revision of clinical, histopathological, and molecular features

Recurrent Chemotherapy Treated Indeterminate Dendritic Cell Tumor: Case Report and Literature Review

Erythematous papules on face and arms of an elderly woman: a case of indeterminate cell histiocytosis

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