A Case of Implant Failure in Partial Wrist Fusion Applying Magnesium-Based Headless Bone Screws

Wichelhaus, Alice; Emmerich, Judith; Mittlmeier, Thomas

doi:10.1155/2016/7049130

Cited by 21 publications

(31 citation statements)

References 14 publications

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“…Additionally, one case series revealed an extensive cystic lesion after Mg implantation in an unstable scaphoid fracture [ 93 ]. Wichelhaus et al described complications in one subject with a scaphoid fracture associated with a scaphotrapezotrapezoidal arthritis treated with a MgYREZr screw [ 90 ]. The patient complained about a painful paraesthesia in the dorsal thumb region and a subcutaneous gas accumulation [ 90 ].…”

Section: Clinical Evaluation Of Mg-based Alloysmentioning

confidence: 99%

Bioresorbable Magnesium-Based Alloys as Novel Biomaterials in Oral Bone Regeneration: General Review and Clinical Perspectives

Herber

Okutan

Antonoglou

et al. 2021

JCM

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Bone preservation and primary regeneration is a daily challenge in the field of dental medicine. In recent years, bioresorbable metals based on magnesium (Mg) have been widely investigated due to their bone-like modulus of elasticity, their high biocompatibility, antimicrobial, and osteoconductive properties. Synthetic Mg-based biomaterials are promising candidates for bone regeneration in comparison with other currently available pure synthetic materials. Different alloys based on Mg were developed to fit clinical requirements. In parallel, advances in additive manufacturing offer the possibility to fabricate experimentally bioresorbable metallic porous scaffolds. This review describes the promising clinical results of resorbable Mg-based biomaterials for bone repair in osteosynthetic application and discusses the perspectives of use in oral bone regeneration.

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Section: Clinical Evaluation Of Mg-based Alloysmentioning

confidence: 99%

Bioresorbable Magnesium-Based Alloys as Novel Biomaterials in Oral Bone Regeneration: General Review and Clinical Perspectives

Herber

Okutan

Antonoglou

et al. 2021

JCM

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“…To date, 16 clinical studies and case reports have been conducted for the clinical implementation of Mg implants alloyed with REE. 27–42 The earliest clinical trials on metatarsal osteotomy fixation for the correction of hallux valgus deformities 31–33 showed similar complications compared to titanium implants. Subsequently, good results were achieved for ankle fracture fixation and intra-articular fragment fixation.…”

Section: Discussionmentioning

confidence: 99%

“…Apart from these promising results, poor outcomes have been reported in two studies with extensive gas formation, loosening, and cystic formation within carpal bones after scapho-trapezio-trapezoid (STT) fusion 27 and secondarily after acute scaphoid fracture fixation. 28 …”

Section: Discussionmentioning

confidence: 99%

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A lean bioabsorbable magnesium-zinc-calcium alloy ZX00 used for operative treatment of medial malleolus fractures

Holweg

Herber

Ornig

et al. 2020

Bone & Joint Research

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Aims This study is a prospective, non-randomized trial for the treatment of fractures of the medial malleolus using lean, bioabsorbable, rare-earth element (REE)-free, magnesium (Mg)-based biodegradable screws in the adult skeleton. Methods A total of 20 patients with isolated, bimalleolar, or trimalleolar ankle fractures were recruited between July 2018 and October 2019. Fracture reduction was achieved through bioabsorbable Mg-based screws composed of pure Mg alloyed with zinc (Zn) and calcium (Ca) ( Mg-Zn0.45-Ca0.45, in wt.%; ZX00). Visual analogue scale (VAS) and the presence of complications (adverse events) during follow-up (12 weeks) were used to evaluate the clinical outcomes. The functional outcomes were analyzed through the range of motion (ROM) of the ankle joint and the American Orthopaedic Foot and Ankle Society (AOFAS) score. Fracture reduction and gas formation were assessed using several plane radiographs. Results The follow-up was performed after at least 12 weeks. The mean difference in ROM of the talocrural joint between the treated and the non-treated sites decreased from 39° (SD 12°) after two weeks to 8° (SD 11°) after 12 weeks (p ≤ 0.05). After 12 weeks, the mean AOFAS score was 92.5 points (SD 4.1). Blood analysis revealed that Mg and Ca were within a physiologically normal range. All ankle fractures were reduced and stabilized sufficiently by two Mg screws. A complete consolidation of all fractures was achieved. No loosening or breakage of screws was observed. Conclusion This first prospective clinical investigation of fracture reduction and fixation using lean, bioabsorbable, REE-free ZX00 screws showed excellent clinical and functional outcomes. Cite this article: Bone Joint Res 2020;9(8):477–483.

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“…The unique environment of the human body, comprising physiological temperature, perfusion, abundance of inorganic ions, amino acids, proteins, and buffering agents, affects the degradation rate and mechanism in as yet unpredictable ways [ 9 ]. This may lead to premature failure of the implanted magnesium structures bringing about grave ramifications to patients’ health [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

The Video Microscopy-Linked Electrochemical Cell: An Innovative Method to Improve Electrochemical Investigations of Biodegradable Metals

et al. 2021

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An innovative, miniature video-optical-electrochemical cell was developed and tested that allows for the conducting of electrochemical corrosion measurements and simultaneous microscopic observations over a small, well-defined surface area of corroding or degrading samples. The setup consisted of a miniature electrochemical cell that was clamped onto the metal sample and fixed under a video microscope before being filled with electrolyte. The miniature cell was comprised of afferent/efferent electrolyte ducts as well as a connection to the Mini Cell System (MCS) for electrochemical measurements. Consequently, all measured and induced currents and voltages referred to the same small area corroding completely within the field of view of the microscope, thus allowing for real-time observation and linking of surface phenomena such as hydrogen evolution and oxide deposition to electrochemical data. The experimental setup was tested on commercial purity (cp) and extra-high purity (XHP) magnesium (Mg) samples using open circuit potential and cyclic voltammetry methods under static and flowing conditions. The corrosion potential was shifted more anodically for cp Mg in comparison to XHP Mg under dynamic conditions. The corrosion current assessed from the cyclic voltametric curves were higher for the cp Mg in comparison to XHP Mg. However, there were no differences between static and flow conditions in the case of XHP Mg in contrast to cp Mg, where the current density was two times higher at dynamic conditions. The measurements and observations with this new method pave the way for a more detailed understanding of magnesium corrosion mechanisms, thus improving predictive power of electrochemical corrosion measurements on newly developed magnesium or other biodegradable alloys applied for medical devices. Different electrochemical tests can be run under various conditions, while being easy to set up and reproduce as well as being minimally destructive to the sample.

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A Case of Implant Failure in Partial Wrist Fusion Applying Magnesium-Based Headless Bone Screws

Cited by 21 publications

References 14 publications

Bioresorbable Magnesium-Based Alloys as Novel Biomaterials in Oral Bone Regeneration: General Review and Clinical Perspectives

Bioresorbable Magnesium-Based Alloys as Novel Biomaterials in Oral Bone Regeneration: General Review and Clinical Perspectives

A lean bioabsorbable magnesium-zinc-calcium alloy ZX00 used for operative treatment of medial malleolus fractures

The Video Microscopy-Linked Electrochemical Cell: An Innovative Method to Improve Electrochemical Investigations of Biodegradable Metals

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