A Case of Idiopathic Vulvar Calcinosis: The First in Japan

Abstract

Idiopathic calcinosis of the scrotum is a rare condition of unknown etiology. As counterparts of this male disorder, only two female cases have been reported. We report a third case, the first of its kind, in Japan. Histochemical stains revealed acid mucopolysaccharide (acid-MPS) within the calcinosis and many infiltrated mast cells near it; these might histogenese the calcium deposition. Immunohistochemically, polyclonal carcinoembryonic antigen (CEA) and keratin stains revealed no positive cells near the calcium depositions.

Idiopathic scrotal calcinosis: a report of four cases and review of the literature

“…Cases of idiopathic calcinosis cutis affecting skin of external genitalia other than the scrotum have been described. Calcified nodules with clinical and histopathologic features similar to those of the scrotal disease and affecting children and adolescents have been reported from the labia majora of the vulva 22,23 . No cysts or epithelial lining of calcified nodules were observed.…”

“…No cysts or epithelial lining of calcified nodules were observed. Fukaya and Ueda 22 were unable to show any positive cells near the calcium deposits on immunohistochemical staining for CEA and keratin. Hutchinson et al .…”

“…Calcified nodules with clinical and histopathologic features similar to those of the scrotal disease and affecting children and adolescents have been reported from the labia majora of the vulva. 22,23 No cysts or epithelial lining of calcified nodules were observed. Fukaya and Ueda 22 were unable to show any positive cells near the calcium deposits on immunohistochemical staining for CEA and keratin.…”

Usual Tumour at an Unusual location – Solitary Sporadic Scapular Sessile Osteochondroma

“…Von Kossa stains the granules black. Fukaya and Ueda found numerous mast cells on toluidine blue staining in these lesions and implicated calcium chelation by mast cell secretions in the pathogenesis [10]. According to Ito et al, IHC panel of EMA, CEA and GCDPF-15 support the eccrine origin of ISC [11].…”

Metastatic calcinosis cutis presenting as bilateral vulval cysts

“…The vulva is an unusual site for any form of cutaneous calcification and, unlike its scrotal counterpart, idiopathic vulval calcinosis is exceptionally rare with fewer than 10 cases described in the literature. Interestingly, most of these cases were in children, 4–7 with only one case report of adult idiopathic vulval calcinosis 8 . There is considerable debate centred on the issue of whether the scrotal form of idiopathic calcinosis cutis is truly idiopathic, with both supporters 9 and opponents 10 of this theory.…”