Metastatic calcinosis cutis presenting as bilateral vulval cysts

Abstract

2 Deeths MJ, Chapman JT, Dellavalle RP et al. Treatment of patch and plaque stage mycosis fungoides with imiquimod 5% cream. J Am Acad Dermatol 2005; 52:275-80. 3 Didona B, Benucci R, Amerio P et al. Primary cutaneous CD30+ T-cell lymphoma responsive to topical imiquimod (Aldara). Br J Dermatol 2004; 150:1198-201. 4 Willemze R, Jaffe ES, Burg G et al. WHO-EORTC classification for cutaneous lymphomas. Blood 2005; 105:3768-85. 5 Schon M, Bong AB, Drewniok C et al. Tumor-selective induction of apoptosis and the small-molecule immune response modifier imiquimod. J Natl Cancer Inst 2003; 95:1138-49. 6 Urosevic M, Maier T, Benninghoff B et al. Mechanisms underlying imiquimod-induced regression of basal cell carcinoma in vivo. Arch Dermatol 2003; 139:1325-32. 7 Schon MP, Wienrich BG, Drewniok C et al. Death receptor-independent apoptosis in malignant melanoma induced by the small-molecule immune response modifier imiquimod. J Invest Dermatol 2004; 122:1266-76. 8 Coors EA, Schuler G, von den Driesch P. Topical imiquimod as treatment for different kinds of cutaneous lymphoma. Eur J Dermatol 2006; 16:391-3.SIR, Calcinosis cutis refers to cutaneous deposition of calcium salts in the skin. It may be classified as metastatic, dystrophic, idiopathic or iatrogenic type based on the aetiopatho-

Acquired perforating calcific collagenosis in a drug addict with rhabdomyolysis and transient hypercalcemia

“…This supposition is supported by the fact that the eruptions subsided after the serum calcium level returned to normal. Metastatic calcinosis cutis with or without perforation or transepidermal elimination secondary to abnormal calcium and/or phosphate metabolism usually occurs as nodular deposits around periarticular skin and/or subcutaneous tissues with nodules of calcific deposits or calcification of vessels as calciphylaxis rather than calcium deposits of dermal collagen fibers as seen in the present case. Pseudoxanthoma elasticum is another skin condition with dermal calcification.…”

“…One unit of the vertical axis stands for CPK: 10 U/L, myoglobin: 100 ng/mL, creatinine: 1 mg/dL, albumin: 1 g/dL, calcium: 1 mg/dL, or phosphate: 1 mg/dL in the serum. The normal ranges of the laboratory values are listed in the text) subcutaneous tissues with nodules of calcific deposits or calcification of vessels as calciphylaxis 1,3,4 rather than calcium deposits of dermal collagen fibers as seen in the present case. Pseudoxanthoma elasticum is another skin condition with dermal calcification.…”