A case of human monocytic ehrlichiosis in Serbia

Arsić, B; Gligič, Ana; Ristanović, Elizabeta; Lako, Branislav; Potkonjak, Aleksandar; Perunicic, Milan; Pavlovic, Momcilo

doi:10.2298/sarh1402079a

Cited by 10 publications

(7 citation statements)

References 17 publications

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“…So far, Serbia and Belgrade comprise a known endemic region for arthropod borne pathogens such as arboviruses - autochthonous cases of arboviral diseases have continuously been reported 8,9 . Nevertheless, the real epidemiological situation regarding arthropod borne infections might be underestimated, since details about arthropod related bacterial agents in Serbia are largely unknown 18 . Majority of previous studies have explored the presence of bacteria in ticks 19–21 .…”

Section: Discussionmentioning

confidence: 99%

Insight into diversity of bacteria belonging to the order Rickettsiales in 9 arthropods species collected in Serbia

Stanojević

Stamenković

et al. 2019

Sci Rep

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Rickettsiales bacteria in arthropods play a significant role in both public health and arthropod ecology. However, the extensive genetic diversity of Rickettsiales endosymbionts of arthropods is still to be discovered. In 2016, 515 arthropods belonging to 9 species of four classes (Insecta, Chilopoda, Diplopoda and Arachnida) were collected in Serbia. The presence and genetic diversity of Rickettsiales bacteria were evaluated by characterizing the 16S rRNA (rrs), citrate synthase (gltA) and heat shock protein (groEL) genes. The presence of various Rickettsiales bacteria was identified in the majority of tested arthropod species. The results revealed co-circulation of five recognized Rickettsiales species including Rickettsia, Ehrlichia and Wolbachia, as well as four tentative novel species, including one tentative novel genus named Neowolbachia. These results suggest the remarkable genetic diversity of Rickettsiales bacteria in certain arthropod species in this region. Furthermore, the high prevalence of spotted fever group Rickettsia in Ixodes ricinus ticks highlights the potential public health risk of human Rickettsia infection.

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Section: Discussionmentioning

confidence: 99%

Insight into diversity of bacteria belonging to the order Rickettsiales in 9 arthropods species collected in Serbia

Stanojević

Stamenković

et al. 2019

Sci Rep

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“…The presumed co-infection with E. chaffeensis was not proven by DNA detection in these cases [129], suggesting a cross reaction. However, seroreactivity to E. chaffeensis in the absence of A. phagocytophilum antibody has been occasionally reported in the European human population [98], and one patient in Serbia was recognized to have clinical illness [134].…”

Section: Human Granulocytic Anaplasmosis In Europementioning

confidence: 99%

A review on the eco-epidemiology and clinical management of human granulocytic anaplasmosis and its agent in Europe

et al. 2019

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Anaplasma phagocytophilum is the agent of tick-borne fever, equine, canine and human granulocytic anaplasmosis. The common route of A. phagocytophilum transmission is through a tick bite, the main vector in Europe being Ixodes ricinus. Despite the apparently ubiquitous presence of the pathogen A. phagocytophilum in ticks and various wild and domestic animals from Europe, up to date published clinical cases of human granulocytic anaplasmosis (HGA) remain rare compared to the worldwide status. It is unclear if this reflects the epidemiological dynamics of the human infection in Europe or if the disease is underdiagnosed or underreported. Epidemiologic studies in Europe have suggested an increased occupational risk of infection for forestry workers, hunters, veterinarians, and farmers with a tick-bite history and living in endemic areas. Although the overall genetic diversity of A. phagocytophilum in Europe is higher than in the USA, the strains responsible for the human infections are related on both continents. However, the study of the genetic variability and assessment of the difference of pathogenicity and infectivity between strains to various hosts has been insufficiently explored to date. Most of the European HGA cases presented as a mild infection, common clinical signs being pyrexia, headache, myalgia and arthralgia. The diagnosis of HGA in the USA was recommended to be based on clinical signs and the patient’s history and later confirmed using specialized laboratory tests. However, in Europe since the majority of cases are presenting as mild infection, laboratory tests may be performed before the treatment in order to avoid antibiotic overuse. The drug of choice for HGA is doxycycline and because of potential for serious complication the treatment should be instituted on clinical suspicion alone.

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“…In Europe, infections have been confirmed by numerous seroepidemiological studies in Italy [9], Czech Republic [10], Portugal [11], Croatia [12], and Serbia [13]. E. chaffeensis causes a potentially severe disease in humans; fever, lethargy, headache, myalgia, reduced platelets and sodium levels and elevated liver enzymes characterize acute infections, resulting in moderate to severe illness.…”

Section: The Disease In Humansmentioning

confidence: 99%

Bacterial canine vector-borne zoonotic diseases in “One Health” concept

Valiakos

2016

Int J One Health

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Canine vector-borne diseases constitute a large group of diseases transmitted by arthropods with worldwide distribution. A wide range of bacterial, viral, and parasitic agents that are transmitted by vectors cause disease to dogs, many of which can also affect humans and thus have an important zoonotic potential. Bacterial agents that are transmitted by vectors have been considered less important than viral or parasitic agents and are not commonly discussed in companion animal practice. However, close contact between pet animals and people offers favorable conditions for transmission of these bacteria. Many of these diseases have become a focus of interest for scientists in recent years. Increase in reservoir abundance, climate change, changing habitat structure, socio-political changes, and imports of dogs for welfare reasons and trade as well as traveling are considered to be potential factors for the pathogens and vectors introduction into new areas. Apart from, the veterinary aspect of these diseases, domestic dogs could play a central epidemiological role in the transmission of bacterial agents to humans, acting as reservoirs and sentinels, a circumstance that requires a One Health approach. This review highlights the most important of these bacterial agents, presenting updated current knowledge with special reference to treatment approach and One Health aspect.

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A case of human monocytic ehrlichiosis in Serbia

Cited by 10 publications

References 17 publications

Insight into diversity of bacteria belonging to the order Rickettsiales in 9 arthropods species collected in Serbia

Insight into diversity of bacteria belonging to the order Rickettsiales in 9 arthropods species collected in Serbia

A review on the eco-epidemiology and clinical management of human granulocytic anaplasmosis and its agent in Europe

Bacterial canine vector-borne zoonotic diseases in “One Health” concept

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