A Case of Hemolytic Uremic Syndrome Associated with Epstein - Barr Virus Infection

Lee, Myong Ho; Cho, Kyoon Seok; Kahng, Kyoung Won; Kang, Chong Myung

doi:10.3904/kjim.1998.13.2.131

Cited by 13 publications

(5 citation statements)

References 7 publications

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“…The etiology of HUS in VTEC-negative patients remains a matter of discussion. Besides non-infectious causes [3,4,5], the possible association with infections due to microorganisms [16,17,18,19,20,21,22] other than VTEC and Shigella has been hypothesized. The presence of high antibody titers and/or seroconversion to adenovirus and non-polio enteroviruses during the acute phase has been shown in isolated cases and a few series [23,24,25,26,27].…”

Section: Introductionmentioning

confidence: 99%

Role of non-polio enterovirus infection in pediatric hemolytic uremic syndrome

Petris

Gianviti

Caione

et al. 2002

Pediatric Nephrology

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Verocytotoxin-producing Escherichia coli(VTEC) infections cause most cases of hemolytic uremic syndrome (HUS); 10-30% of patients, however, are negative for VTEC infection. The etiology of HUS in VTEC-negative cases remains poorly understood. Before the association between VTEC infection and HUS was recognized, sporadic cases of HUS with enterovirus infection were reported in the literature. Since May 1988, most cases of HUS in Italy have been reported to the Italian surveillance system, and in 73% of these, evidence of VTEC infection was demonstrated. The aim of this study was to determine whether the frequency of enteroviral infections was different in the acute phase of VTEC-positive and VTEC-negative HUS. Eighty-nine patients were investigated for enteroviral infection, of whom 58 were VTEC positive and 31 VTEC negative. Two serum samples from each patient were examined for seroconversion to enterovirus (coxsackie, echovirus, and picornavirus) by a complement fixation test. Serological evidence of acute infection with non-polio enterovirus was found in 33 patients (37%) [20/58 (34.5%) VTEC positive and 13/31 (41.9%) VTEC negative]. There was no statistically significant difference between the two groups. These results demonstrate that there are no significant differences for enteroviral infection in VTEC-positive and VTEC-negative patients and, therefore, enteroviral infections should not be considered a cause of HUS in VTEC-negative children.

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Section: Introductionmentioning

confidence: 99%

Role of non-polio enterovirus infection in pediatric hemolytic uremic syndrome

Petris

Gianviti

Caione

et al. 2002

Pediatric Nephrology

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“…Both patients also had a history of severe, sometimes bloody, diarrhea [8,9]. Nonetheless, no stool testing for germs harboring genes for shigatoxin was performed [5].…”

Section: Discussionmentioning

confidence: 98%

Hemolytic uremic syndrome linked to infectious mononucleosis

et al. 2003

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A 12-month-old boy developed a mild hemolytic uremic syndrome with no acute diarrheal prodrome. The typical clinical, hematological, and serological features of infectious mononucleosis were also noted. The clinical course of both hemolytic uremic syndrome and infectious mononucleosis was uneventful. A review of the literature disclosed that hemolytic uremic syndrome has been noted in two adolescents with infectious mononucleosis.

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“…Bacterial infections caused by organisms like S. pneumoniae and Salmonella also cause HUS (Albaqali et al , 2003; Waters et al , 2007). Viral infections such as influenza virus, parvovirus, ECHO (enteric cytopathic human orphan) virus, coxsackie virus, cytomegalovirus and Epstein–Barr virus are associated with HUS (Cavagnaro & Barriga, 2000; Larke et al , 1983; Lee et al , 1998; Seward et al , 1999; Trachtman et al , 2011; Waiser et al , 1999). Our patient is perhaps the first case of P. aeruginosa infection with the clinical manifestations of HUS in the medical literature.…”

Section: Discussionmentioning

confidence: 99%

“…Haemolytic uraemic syndrome (HUS) is a recognized complication of Shiga toxin-producing Escherichia coli (STEC) and Shigella dysenteriae type 1 infections and is characterized by microangiopathic haemolytic anaemia, thrombocytopenia and renal failure (Taylor, 2008). Other infectious agents reported as causing HUS include Streptococcus pneumoniae , Citrobacter freundii , Salmonella typhi , Epstein–Barr virus, H1N1 influenza A and other viruses (Albaqali et al , 2003; Copelovitch & Kaplan, 2008; Lee et al , 1998; Trachtman et al , 2011; Waters et al , 2007). We report the case of a 2-year-old girl diagnosed with Pseudomonas aeruginosa sepsis and shock who also developed features of HUS.…”

Section: Introductionmentioning

confidence: 99%

Haemolytic uraemic syndrome associated with Pseudomonas aeruginosa sepsis

Parameswaran

Rustagi

Prabha

et al. 2013

Journal of Medical Microbiology

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Haemolytic uraemic syndrome (HUS) is a recognized complication of infection with Shiga toxinproducing Escherichia coli (STEC) and Shigella dysenteriae type 1. Infections with other microorganisms, especially Streptococcus pneumoniae, have been cited as causes of HUS. In addition, influenza virus and other viruses may rarely be associated with this syndrome. A 2-year-old girl presented with severe Pseudomonas aeruginosa sepsis with renal failure and ecthyma gangrenosum. Further investigations revealed features of HUS. She was managed with antibiotics and other supportive measures including peritoneal dialysis, and subsequently made a full recovery. A possible role of neuraminidase in the pathogenesis of P. aeruginosa-associated HUS was proposed. This is the first reported case of P. aeruginosa sepsis leading to HUS.

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A Case of Hemolytic Uremic Syndrome Associated with Epstein - Barr Virus Infection

Cited by 13 publications

References 7 publications

Role of non-polio enterovirus infection in pediatric hemolytic uremic syndrome

Role of non-polio enterovirus infection in pediatric hemolytic uremic syndrome

Hemolytic uremic syndrome linked to infectious mononucleosis

Haemolytic uraemic syndrome associated with Pseudomonas aeruginosa sepsis

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