A case of glassy cell carcinoma of the uterine cervix that responded to neoadjuvant chemotherapy with paclitaxel and carboplatin

Abstract

Glassy cell carcinoma of the uterine cervix is a rare tumor, and has a poor prognosis because of its aggressive clinical behavior and resistance to radiotherapy and chemotherapy. We report a case of bulky glassy cell carcinoma of the uterine cervix that effectively responded to paclitaxel and carboplatin in a neoadjuvant setting. The patient was a 30-year-old woman who became aware of vaginal bleeding and was referred to our hospital because of a cancerous tumor of the uterine cervix. Physical examination showed the cervical tumor to be approximately 8 cm in diameter with no involvement of the parametrium or vagina. The biopsy results suggested a diagnosis of glassy cell carcinoma. The final diagnosis was glassy cell carcinoma of the uterine cervix, stage 1b2. Neoadjuvant chemotherapy with paclitaxel and carboplatin was administered for downstaging. The response rate was 67.9% (partial response) under magnetic resonance imaging, and elevated serum cancer-related antigen 125 (119 U/ml) and squamous cancer cell antigen (34 ng/ml) were reduced to 34 U/ml and 3.3 ng/ml, respectively. Following neoadjuvant chemotherapy, she underwent radical hysterectomy and adjuvant chemotherapy with the same regimen. The clinical course was very good. We speculate that glassy cell carcinoma is a sensitive tumor to paclitaxel and carboplatin. Further evaluation concerning diagnosis and treatment, however, is needed to improve the prognosis of patients with glassy cell carcinoma.

Adjuvant combined paclitaxel and carboplatin chemotherapy for glassy cell carcinoma of the uterine cervix: Report of three cases with clinicopathological analysis

“…The other two women with adjuvant PC chemotherapy are alive in disease‐free state in for more than 4.5 years. Some reports showed that PC chemotherapy is effective for primary and recurrent GCC of the cervix 8–11 . Nasu et al .…”

“…Some reports showed that PC chemotherapy is effective for primary and recurrent GCC of the cervix. [8][9][10][11] Nasu et al reported a case of glassy cell carcinoma treated using conventional radiation therapy and six courses of triweekly PC chemotherapy. 12 We also considered that adjuvant PC chemotherapy is effective for GCC.…”

Multimodal treatment for glassy cell carcinoma of the uterine cervix

“…Takekuma et al. 15 reported a case of bulky GCC of the uterine cervix that responded effectively to paclitaxel and carboplatin in a neoadjuvant setting. Taken together, combination chemotherapy with paclitaxel and carboplatin seem to be effective for glassy cell carcinoma of the cervix.…”

Glassy cell carcinoma of cervix

“…Пациенткам с опухолями больших размеров в качестве неоадъювантного лечения может быть проведена химиотерапия по схеме паклитаксел + карбоплатин, это лечение позволяет уменьшить размер новообразования, что, в свою очередь, дает возможность провести хирургическое лечение таких пациенток; также данная схема лечения показала свою эффективность при рецидивах GCC [21][22][23]. При местно-распространенных формах заболевания, по данным ряда авторов, эффективными оказались схемы лекарственной терапии карбоплатин + этопозид + эпирубицин и цисплатин + этопозид + митомицин C [24,25].…”