A case of folliculosebaceous cystic hamartoma: a rare and clinically indistinct lesion

Morse, Daniel C; Tschen, Jaime A.

doi:10.5070/d3247040921

Cited by 3 publications

(6 citation statements)

References 8 publications

(19 reference statements)

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“…Based on this term, folliculosebaceous cystic hamartomas define a mixture of epidermal, dermal, adnexal, and hypodermal cells that show histologically dilated follicular structures with infundibular cystic structures and surrounding multiple sebaceous lobules. [ 2 , 8 , 9 , 16 , 20 , 21 ]. In the current literature, only eight cases were reported with giant folliculosebaceous cystic hamartoma.…”

Section: Discussionmentioning

confidence: 99%

“…In summary of the represented cases up to the present date, the typical clinical presentation of FSCH appears in the form of solitary, unilateral, skin-colored, protruding/pedunculated benign papules or nodules, which occur commonly on the face, especially on the nose [ 8 , 21 , 27 , 32 ]. Outside of facial predilection, other cases have already been described on the auricle and scalp [ 24 , 33 , 34 , 35 ], lower extremity [ 36 ], genital [ 11 , 37 , 38 ], nipple [ 16 , 39 , 40 ], upper lip and labial mucosa [ 41 ], and back [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

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Giant Folliculosebaceous Cystic Hamartoma of the Face

Tasar,

Peckruhn,

Tittelbach

2023

Dermatopathology

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Folliculosebaceous cystic hamartoma (FSCH) is a rare and benign form of cutaneous hamartomas. These skin lesions often lead to clinical and histopathological misdiagnosis due to their similarities to cutaneous lesions with overproduction of clustered sebaceous glands. Clinically, the lesions often present as solitary, skin-colored, pedunculated warts to cauliflower-like, exophytic papules and nodules, usually with a diameter ranging 0.5–1.5 cm that rarely exceed 2 cm in size. Only a small number of giant variants are reported in the literature with a diameter in the range of 5–23 cm. The vast majority of the lesions appear in the central face and show a striking predilection for the nose, ears, and scalp, but also emerge on the nipples, extremities, and genitals. Histologically, the epithelial components of folliculosebaceous cystic hamartoma comprise dilated infundibular cystic proliferation with surrounding mesenchymal components, which commonly include fibroplasia and vascular and adipose tissue proliferation. These histological characteristics were coined by Kimura and colleagues (1991). To the best of our knowledge, our case represents the biggest variant of giant folliculosebaceous cystic hamartoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Giant Folliculosebaceous Cystic Hamartoma of the Face

Tasar,

Peckruhn,

Tittelbach

2023

Dermatopathology

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“…Folliculosebaceous cystic hamartoma is, probably, an underdiagnosed lesion, because of the lack of specific clinical features [ 2 , 4 ]. Clinically, it usually appears as a slow growing, skin colored, cutaneous papule or nodule, sessile or pedunculated.…”

Section: Introductionmentioning

confidence: 99%

“…Clinically, it usually appears as a slow growing, skin colored, cutaneous papule or nodule, sessile or pedunculated. Some lesions may appear as red or dome-shaped nodules, sometimes showing superficial teleangiectasias or a warty appearance [ 2 , 3 , 4 , 5 ]. No statistically significant predominant sex incidence has been found [ 2 , 3 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Histopathologically, folliculosebaceous cystic hamartoma appears as a complex lesion composed of epithelial, follicular and sebaceous, and mesenchymal tissues. The tumor shows a cystically dilated hair follicle with multiple radiating sebaceous glands, associated with a mesenchymal component, generally consisting of abundant fibrous stroma, small venules and a variable proportion of mature adipose tissue [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Folliculosebaceous Cystic Hamartoma with Spindle Cell Lipomatous and Neural Components

Urso¹,

Yarygina²

2023

Dermatopathology

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Folliculosebaceous cystic hamartoma is a cutaneous malformation composed of a cystic folliculosebaceous structure associated with mesenchymal elements, generally consisting of fibrous stroma, adipocytes and small vascular channels. We report the case of a 55-year-old female patient with a cutaneous nodule of the right nasal wing. Microscopically, the lesion showed a dilated hair follicle with multiple sebaceous glands, surrounded by a mesenchymal component composed of fibromyxoid stroma, spindle cells, mature-appearing adipocytes and collagen bundles, resembling spindle cell lipoma, associated with an additional neural component, consisting of small nerve bundles. In folliculosebaceous cystic hamartoma, the association of spindle cell lipomatous and neural components has not previously reported.

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Folliculosebaceous Cystic Hamartoma Mimicking Preauricular Sinus Cyst

Subaşi¹,

Inceoglu²,

Sertkaya³

2021

Indian Journal of Dermatology

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Folliculosebaceous cystic hamartoma (FSCH) is a rare cutaneous hamartoma that consists of follicular, sebaceous, and mesenchymal elements. These lesions are mostly seen on the central face and scalp of adults and mostly present as single 0.5-1.5 cm papules or exophytic nodules. A 17-year-old female patient presented at our clinic with the complaint of swelling, pain and discharge in front of the left ear, which had been recurrent since childhood. The lesion was clinically suspected to be an infected preauriculer sinus cyst. After the medical treatment, the patient was operated on with a pre-diagnosis of preauricular sinus cyst. Histopathological findings revealed FSCH. To the best of our knowledge, this is the first reported case of FSCH originating from the preauricular region, located subcutaneously.

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A case of folliculosebaceous cystic hamartoma: a rare and clinically indistinct lesion

Cited by 3 publications

References 8 publications

Giant Folliculosebaceous Cystic Hamartoma of the Face

Giant Folliculosebaceous Cystic Hamartoma of the Face

Folliculosebaceous Cystic Hamartoma with Spindle Cell Lipomatous and Neural Components

Folliculosebaceous Cystic Hamartoma Mimicking Preauricular Sinus Cyst

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