A case of fatal cryptococcus meningitis with intraventricular granuloma

Müller, Wilhelm; Schorre, W.; Suchenwirth, R; Zitz, H. M.; Konorza, G.

doi:10.1007/bf01402064

Cited by 11 publications

(3 citation statements)

References 32 publications

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“…Eosinophils are also observed during the inflammatory response to C. neoformans infection. Eosinophils are rarely found in the cerebrospinal fluid of patients with cryptococcal meningitis (1,56), but patients with peripheral blood eosinophilia and C. neoformans pulmonary infections have been described (25,39). Eosinophils were reported in a pleural effusion due to C. neoformans infection (25) and in the inflammatory response of an epidural abscess (9).…”

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confidence: 99%

Eosinophil-Cryptococcus neoformans interactions in vivo and in vitro

et al. 1997

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Eosinophils are components of inflammatory responses to a variety of pathogens. Although a variety of beneficial and harmful functions have been ascribed to these cells, their role in protection against infectious agents remains uncertain. Previous studies have reported eosinophilic pneumonia in mice infected intratracheally with Cryptococcus neoformans. We confirmed this observation and studied the inflammatory response in the lung at day 14 by light and electron microscopy. Immunostaining for glucuronoxylomannan showed isolated cryptococci inside the eosinophilic cuffs. Eosinophils were found to be in close association with C. neoformans in vivo. Cryptococci were associated with eosinophils within eosinophilic perivascular cuffs, within granulomas, and lining the alveolar space. To further investigate this phenomenon in vitro, we isolated rat peritoneal eosinophils and studied cryptococcus-eosinophil interactions in the presence and absence of anticapsular immunoglobulin G1 (IgG1) and IgE monoclonal antibody (MAb). Eosinophils phagocytosed C. neoformans only in the presence of specific antibody. Phagocytosis was rapid, and dense rings that appeared to consist of granule contents were formed around the organisms. Mast cells were observed to occasionally phagocytose C. neoformans in vitro in the presence of IgE MAb. Our observations suggest that eosinophils may be effector cells against C. neoformans.

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Eosinophil-Cryptococcus neoformans interactions in vivo and in vitro

et al. 1997

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“…Meningitis due to coccidioidomycosis (Coccidioides immitis) occurs as part of the disseminated syndrome where eosinophilic pleocytosis may be prominent [4]. Cryptococcal meningitis (Crypotococcus neoformans) is rarely a cause of EM [5]. EM has been noted in various bacterial and viral infections, but in these cases the association with eosinophilia appears to be circumstantial [6].Visceral myiasis involving the central nervous system by botflies has been shown to be associated with EM [7].…”

Section: Etiologymentioning

confidence: 99%

Eosinophilic meningitis

Slom¹

2003

Curr Infect Dis Rep

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Eosinophilic meningitis (EM) is a distinct clinical entity that may have infectious and noninfectious causes. Worldwide, infection with the helminthic parasite, Angiostrongylus cantonensis, is the most common infectious etiology. Historically, this infection has been acquired through ingestion of competent intermediate and paratenic (carrier) hosts or contaminated food in Southeast Asia and the Pacific Islands. A recent outbreak of A. cantonensis-associated EM among US travelers to Jamaica and subsequent parasitologic surveys of local snails and rats confirm earlier case reports and engender a wider appreciation of the Caribbean islands as a new region for endemic A. cantonensis infections. Clinically, eosinophilia is not always present in the cerebrospinal fluid or in the peripheral blood during the initial manifestions of A. cantonensis-associated EM, which include headache and cutaneous sensory alterations. Effective management of patients involves careful attention to the control of intracranial pressure. Steroid therapy without specific anthelmintic treatment is safe and effective in control of headache of adult patients with A. cantonensis-associated EM.

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“…In comparison, CNS cryptococcosis is only rarely accompanied by CSF eosinophilia (Schermoly and Hinthorn, 1988). Nevertheless, a case of fatal Cryptococcus meningitis with intraventricular granuloma was reported (Muller et al, 1978). Generally, some viral, rickettsial and bacterial infections are associated with CSF eosinophilia which were rare and non-causes of eosinophilic meningitis at least in animals (Uchida et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Egyptian Eosinophilic and Infectious Meningoencephalitis and Their Impact on Psychological Aspects

EL-BAHNASAWY¹,

Feky²,

Morsy³

2016

JESP

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Meningoencephalitis is an acute inflammation of the brain and spinal cord & their covering protective membranes. Meningitis can be life-threatening because of the inflammation's proximity to the brain and spinal cord; therefore, the condition is classified as a medical emergency. The commonest symptoms of meningitis are headache and neck stiffness associated with fever, confusion or altered consciousness, vomiting, and an inability to tolerate light (photophobia) or loud noises (phonophobia). Children often exhibit only nonspecific symptoms, such as irritability and drowsiness. If a rash is present, it may indicate a particular cause of meningitis; for instance, meningitis caused by meningococcal bacteria may be accompanied by a characteristic rash. A broad variety of allergic, infectious, neoplastic, and idiopathic diseases are associated with increased blood and/or tissue eosinophilia and range in severity from self-limited conditions to life-threatening disorders. Although accepted upper limits of normal blood eosinophil numbers vary somewhat, a value above 600 eosinophils /microL of blood is abnormal in the vast majority of cases. Generally speaking, there are several possible causes of eosinophils in the CSF; undoubtedly parasitic infection is one of the main causes.

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A case of fatal cryptococcus meningitis with intraventricular granuloma

Cited by 11 publications

References 32 publications

Eosinophil-Cryptococcus neoformans interactions in vivo and in vitro

Eosinophil-Cryptococcus neoformans interactions in vivo and in vitro

Eosinophilic meningitis

Egyptian Eosinophilic and Infectious Meningoencephalitis and Their Impact on Psychological Aspects

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