A case of false positive Troponin I in a patient affected by cryoglobulinemic vasculitis

Bellan, Mattia; Pirisi, Mario; Bellomo, Giorgio; Sainaghi, Pier Paolo

doi:10.4081/reumatismo.2017.941

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…An increase in cTn levels in patients with stable coronary arterial disease indicates an increased risk of cardiovascular death [1,2]. A false positive result may be caused by the presence of rheumatoid factor or heterophilic antibodies [3,4]. Increased cTn values also occurred in patients with stroke [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Troponin Levels in Patients in Acute Phase of Stroke

Dziadkowiak¹

2018

J Cardiovasc Med Cardiol

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Background and Purpose: The purpose of this study was to assess the correlation of cTn levels in the acute phase of ischemic stroke with the extent of stroke, the degree of disability assessed on the modifi ed Rankin Scale, and their prognostic signifi cance. Methods: Patients were divided into 3 groups: (A) ischemic strokes, (B) ischemic strokes followed by hemorrhagic transformation, and (C) hemorrhagic strokes, excluding patients with symptoms of acute coronary syndrome. Cardiac troponin levels (cTn) were determined by venipuncture using the Abbott ARCHITECT STAT hs Troponin-I assay. Results: Seventy-four percent of the patients (128/173) were diagnosed with ischemic stroke, 14% (24/173) with ischemic stroke followed by hemorrhagic transformation, and 12% (21/173) with hemorrhagic stroke. The mean troponin level was 0.21 ± 1.15 ng/mL in the whole group (from 0 up to 12.4 ng/mL), while in the group with ischemic stroke the mean troponin level was 0.15 ± 076 ng/mL (from 0 up to 7.9 ng/mL). In 79/128 patients with ischemic stroke, troponin values were normal. Troponin levels were signifi cantly correlated with the modifi ed Rankin Scale on admission and on the day of discharge (p = 0.0001). Hyperlipidemia present in 104 patients had a statistically signifi cant effect on statistically higher troponin levels (0.15 ± 0.80 ng/mL). In 48% of the cases, vascular lesions involved the vascular area of the middle cerebral artery (83 patients), while the rarest ones were in the basal ganglia area (4 patients). In the case of cerebellum changes, statistically signifi cantly lower troponin levels were found than in the other groups (p = 0.050). Conclusions: A moderate increase in troponin was observed in patients with cerebral stroke. Elevated troponin levels indicated the lesion size and correlated with the degree of disability. High troponin levels can be a prognostic factor in the course of stroke.

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