Troponin Levels in Patients in Acute Phase of Stroke

Abstract

Background and Purpose: The purpose of this study was to assess the correlation of cTn levels in the acute phase of ischemic stroke with the extent of stroke, the degree of disability assessed on the modifi ed Rankin Scale, and their prognostic signifi cance. Methods: Patients were divided into 3 groups: (A) ischemic strokes, (B) ischemic strokes followed by hemorrhagic transformation, and (C) hemorrhagic strokes, excluding patients with symptoms of acute coronary syndrome. Cardiac troponin levels (cTn) were determined by venipuncture using the Abbott ARCHITECT STAT hs Troponin-I assay. Results: Seventy-four percent of the patients (128/173) were diagnosed with ischemic stroke, 14% (24/173) with ischemic stroke followed by hemorrhagic transformation, and 12% (21/173) with hemorrhagic stroke. The mean troponin level was 0.21 ± 1.15 ng/mL in the whole group (from 0 up to 12.4 ng/mL), while in the group with ischemic stroke the mean troponin level was 0.15 ± 076 ng/mL (from 0 up to 7.9 ng/mL). In 79/128 patients with ischemic stroke, troponin values were normal. Troponin levels were signifi cantly correlated with the modifi ed Rankin Scale on admission and on the day of discharge (p = 0.0001). Hyperlipidemia present in 104 patients had a statistically signifi cant effect on statistically higher troponin levels (0.15 ± 0.80 ng/mL). In 48% of the cases, vascular lesions involved the vascular area of the middle cerebral artery (83 patients), while the rarest ones were in the basal ganglia area (4 patients). In the case of cerebellum changes, statistically signifi cantly lower troponin levels were found than in the other groups (p = 0.050). Conclusions: A moderate increase in troponin was observed in patients with cerebral stroke. Elevated troponin levels indicated the lesion size and correlated with the degree of disability. High troponin levels can be a prognostic factor in the course of stroke.

Correlation between Serum Troponin-I Levels and Acute Stroke in Coronary Artery Disease Patients

“…9 While another study showed the opposite results, where 45% of study patients were male. 10 We also observed that about 58% of the study patients had right-sided weakness and 42% had left-sided weakness, indicating the involvement of the left side of the brain in AIS. Thus, in my present study, patients had more left-side brain involvement.…”

The impact of cardiac troponin in elderly patients in the absence of acute coronary syndrome: A systematic review

“…Seven studies were conducted in the United States [5] , [7] , [13] , [24] , [25] , [31] , [33] , two in Canada [22] , [23] , nine in Europe [4] , [10] , [12] , [20] , [21] , [26] , [27] , [29] , [32] , two in Australia [6] , [30] , and three studies in Asia [8] , [9] , [11] .…”

“…Although the correlation between cTn and comorbidity has been individually studied [4] , [5] , [6] , [8] , [10] , [11] , [12] , [13] , [14] , [20] , [35] , the possibility of simultaneous comorbidities is not clarified. Therefore, there is higher probability of selection bias.…”

“…Although elevated cTn values have been addressed as a significant independent risk factor for mortality and morbidity in elderly with diabetes mellitus (DM) [4] , hypertension (HTN) [5] , renal insufficiency (RI) [6] , [7] , cardiomyopathy (CM) [8] , pulmonary hypertension (PHTN) [9] , chronic obstructive pulmonary disease (COPD) [10] , stroke [11] , [12] , [13] , obstructive sleep apnea (OSA) [14] , and different types of cancer [15] , [16] , [17] , a systematic review to identify the underlying cause of an elevated cTn values for this proportion of elderly patients is scarce.…”