A case of extramedullary plasmacytoma arising from the lacrimal gland: a case report

Recurrence of Multiple Myeloma with Soft Tissue Plasmacytoma Presenting as Unilateral Proptosis

“…With extension of the tumour, papilloedema and ophthalmoplegia can occur due to compression of the optic nerve and extraocular muscles (Adkins et al, 1996;Chim et al, 2003;Iida et al, 2005;Lazaridou et al, 2000;Movsas et al, 2000;Palamar et al, 2008;Uceda-Montanes et al, 2000 ) . The latter presentation is illustrated in our patient.…”

“…The median survival in patients with recurrence with EMP without systemic relapse is 12 months and worse if there is systemic involvement. Orbital involvement is associated with an even poorer prognosis compared to other EMPs (Iida et al, 2005). Nevertheless, patients need to be followed up closely after treatment of multiple myeloma to determine the complete remission of the disease and for early detection of relapse so that early treatment can be instituted.…”

Good Anatomical Outcome of Orbital Plasmacytoma Following Chemo-Radiotherapy

“…These soft tissue tumors are commonly classified as either solitary plasmacytomas of the bone (SPB) or extramedullary plasmacytomas (EMP). While extramedullary plasmacytoma commonly occurs in the upper respiratory tract, involvement of the orbit, eyelid, ocular adnexa and conjunctiva occurs rarely (Lida et al 2005).…”

Plasmacytoma of the orbit involving lacrimal gland with secondary transformation into multiple myeloma: case report

“…Plasmacytoma is a solitary, localized tumor collection of clonal neoplastic plasma cells capable of producing a monoclonal immunoglobulin (1) . These tumors are classified as either solitary plasmacytomas of the bone (SPB) or extramedullary plasmacytomas (EMP) of soft tissue (2) .…”

“…Extramedullary plasmacytoma of the orbit, eyelid, ocular adnexa, as of the conjunctiva, occurs rarely (1,6) , and appears to have a different natural history than SPB, with a lower incidence of conversion to multiple myeloma. In contrast, SPB continues to convert to multiple myeloma even after 17 years.…”