A Case of Esophageal So-called Carcinosarcoma, which Proliferated after Radiochemotherapy Against Squamous Cell Carcinoma

省三, 佐々木; 慶幸, 黒阪; 康二郎, 舩木; 良男, 道輪; 茂, 竹川; 正人, 桐山; 篤弘, 川島; 靖彦, 小島

doi:10.5833/jjgs.40.253

Cited by 5 publications

(2 citation statements)

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“…Sasaki et al reported a case of SCC confi rmed by biopsy that recurred as carcinosarcoma after the patient had received chemoradiotherapy. They speculated that the SCC cells underwent metaplastic changes, transforming the tumor into "so-called carcinosarcoma" [20]. In each of the patients described here, preoperative endoscopy and CT scan showed a tumor protruding into the esophageal lumen.…”

Section: Discussionmentioning

confidence: 97%

“…Although longterm outcomes remain unclear, it appears that transient local control can be expected after radiotherapy. All three patients with unresected carcinosarcoma who received chemoradiotherapy had at least a partial response; however, two died of their disease and one had an unknown longterm outcome (cases 15 to 17) [19][20][21]. Currently available fi ndings thus indicate that radiotherapy or chemoradiotherapy can control the primary lesions; however, there is no evidence suggesting that radiotherapy or chemoradiotherapy is as effective as surgery.…”

Section: Discussionmentioning

confidence: 98%

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Therapeutic effectiveness of chemoradiotherapy for carcinosarcoma of the esophagus: two case reports and a review of the literature

Zuiki

Hosoya

et al. 2009

Esophagus

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Esophageal carcinosarcoma is an extremely rare tumor, and surgery is the mainstay of treatment. We report two patients with carcinosarcoma of the esophagus who received neoadjuvant chemoradiotherapy and underwent curative resection. Patient 1 was a 50-year-old man with a type 2 lesion in the upper thoracic esophagus; clinical stage was T3 or partial T4N1M0. After chemoradiotherapy the tumor and the lymph nodes become smaller, and subtotal esophagectomy was performed. Patient 2 was a 66-year-old man with a protruding lesion in the lower thoracic esophagus. Preoperative chemoradiotherapy was administered, and he had a partial response. However, surgery was postponed because of pneumonia; 11 months later, tumor enlargement was confi rmed and we then performed subtotal esophagectomy. The therapeutic role and effectiveness of both chemotherapy and radiotherapy remain unclear. We reviewed 26 previously reported cases of esophageal carcinosarcoma treated by chemotherapy, radiotherapy, or both. These fi ndings suggest that preoperative chemoradiotherapy may be effective for downstaging the primary tumor in patients with advanced esophageal carcinosarcoma.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 98%