A case of primary hepatic carcinosarcoma with long-term survival after the operation

Yamamoto, Toshio; Unate, Hitoshi; Makino, Masato; Hayashi, Eiichi

doi:10.3919/jjsa.73.102

Nihon Rinsho Geka Gakkai Zasshi (J Jpn Surg Assoc)

2012

DOI: 10.3919/jjsa.73.102

|View full text |Cite

A case of primary hepatic carcinosarcoma with long-term survival after the operation

Toshio Yamamoto¹,

Hitoshi Unate²,

Masato Makino³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2013

2016

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Surgical outcomes for 131 cases of carcinosarcoma of the hepatobiliary tract

Okabayashi¹,

Shima²,

Iwata³

et al. 2013

J Gastroenterol

View full text Add to dashboard Cite

Carcinosarcoma of the hepatobiliary tract is highly aggressive and has a poor prognosis even after curative resection. The purpose of this study was to collate and analyze published data to clarify the surgical outcome of carcinosarcoma of the hepatobiliary tract and the relationships between potential prognostic factors and survival after surgery. We surveyed worldwide literature from 1970 to 2012 and obtained clinicopathological data for 131 patients who had undergone surgical resection for carcinosarcoma of the hepatobiliary tract, including one patient from our clinic. The relationships between potential prognostic factors and survival rates were examined using the Kaplan-Meier method and the log-rank test. The overall 1-, 3-, and 5-year survival rates for patients with carcinosarcoma of the hepatobiliary tract after surgery were 44.0, 29.3, and 27.0 %, respectively. In univariate analyses, age and gender were not significant prognostic factors; however, advanced stage according to the classification of the Union for International Cancer Control in resected specimens was significantly associated with a shorter survival time after surgery. Although carcinosarcoma of the hepatobiliary tract remains a rare disease worldwide, its poor prognosis, even after curative resection, demands further epidemiological and pathological study that could lead to the development of new management strategies.

show abstract

Surgical outcomes for 131 cases of carcinosarcoma of the hepatobiliary tract

Okabayashi¹,

Shima²,

Iwata³

et al. 2013

J Gastroenterol

View full text Add to dashboard Cite

show abstract

Carcinosarcoma of the liver: report of a case

et al. 2013

View full text Add to dashboard Cite

A 64-year-old Japanese woman without a history of viral hepatitis was admitted for investigation of a huge liver mass. The tumor, measuring 14 × 12 × 22 cm, had invaded the diaphragm, right lung, and inferior vena cava. Serum examinations demonstrated high levels of carbohydrate antigen 19-9 (CA19-9), and the Child-Pugh score was A. She underwent right lobectomy of the liver and partial resection of the right diaphragm, right lung, and inferior vena cava. Radio- and chemotherapy were also given, but she died of recurrence 3 months after surgery. Microscopically, the tumor exhibited intermingled adenocarcinomatous and atypical mesenchymal components. The carcinomatous component was positive for cytokeratins 7, 19, and 20, chromogranin A, epithelial membrane antigen, c-KIT, and vimentin. The sarcomatous component was positive for vimentin and c-KIT. A review of 36 cases of hepatic carcinosarcoma revealed the following: chronic hepatitis or cirrhosis in 57 % of the patients; increased serum CA19-9 levels in 30 %; a mean tumor diameter of 10 cm; invasion of the adjacent organs or metastasis to distant organs in 47 %; wide intrahepatic infiltration in 44 %; and 50 % survival of only 5 months. Significant differences were seen according to tumor diameter (diameter >5 cm; p < 0.05), wide intrahepatic infiltration (p < 0.05), and extrahepatic invasion/metastasis (p < 0.01). Neither chemotherapy nor radiotherapy contributed to prognosis, but surgical resection resulted in some improvement (p < 0.05).

show abstract

A Resected Primary Hepatic Carcinosarcoma with an Intrabiliary Growth Component

Okuno

Honda

Kurata

et al. 2016

Jpn J Gastroenterol Surg, Nihon Shokaki Geka Gakkai zasshi

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

A case of primary hepatic carcinosarcoma with long-term survival after the operation

Cited by 3 publications

References 13 publications

Surgical outcomes for 131 cases of carcinosarcoma of the hepatobiliary tract

Surgical outcomes for 131 cases of carcinosarcoma of the hepatobiliary tract

Carcinosarcoma of the liver: report of a case

A Resected Primary Hepatic Carcinosarcoma with an Intrabiliary Growth Component

Contact Info

Product

Resources

About