A case of Ehlers‐Danlos‐like syndrome in a rabbit with a review of the disease in other species

Sinke, Jacqueline D.; Dijk, J. E. van; Willemse, Ton

doi:10.1080/01652176.1997.9694768

Cited by 29 publications

(23 citation statements)

References 20 publications

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“…These ultrastructural findings are consistent with those reported by several authors as the most characteristic of this type of collagen dysplasia in different animal species. 2,7,13,18,19 In transverse sections, although they varied in diameter, the fibrils had regular contours, with no occurrence of bizarre forms like those reported for some cases involving cattle and cats. 7,10 Two forms of the disease have been described in cats, both of which are linked to autosomal genes.…”

Section: Figmentioning

confidence: 97%

Collagen Dysplasia (Cutaneous Asthenia) in a Cat

Sequeira¹,

Rocha²,

Bandarra³

et al. 1999

Vet Pathol

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Abstract.Hereditary collagen dysplasias comprise a complex group of connective-tissue disorders that result in the reduced tensile strength of affected tissues. These processes are called cutaneous asthenia in the skin of dogs and cats. We report here the case of a crossbred male cat, aged 6 months, that presented with two skin wounds in the region of the right thorax and right iliac tuberosity. The skin of these regions and of the animal's dorsum was hyperextensible, smooth to the touch, and easily torn with minor trauma. Microscopic examination of skin samples revealed reduced dermal connective tissue consisting of shortened and fragmented collagen fibers. Normal fibers were intermingled with altered fibers. Ultrastructural changes in collagen fibers included disorientation of fibrils within the same bundle, marked spacing differences, and variation in the diameter of transverse sections. The fibrils maintained the transverse striations characteristic of normal collagen.

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Section: Figmentioning

confidence: 97%

Collagen Dysplasia (Cutaneous Asthenia) in a Cat

Sequeira¹,

Rocha²,

Bandarra³

et al. 1999

Vet Pathol

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“…67 It results from mutations in collagen-forming genes or collagensynthesizing enzymes that cause joint laxity and skin hyperextensibility. 67 It results from mutations in collagen-forming genes or collagensynthesizing enzymes that cause joint laxity and skin hyperextensibility.…”

Section: Ehlers-danlos-like Syndromementioning

confidence: 99%

Dermatologic Diseases

Hess¹,

Tater²

2012

Ferrets, Rabbits, and Rodents

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“…More than 10 subtypes of EDS have been classified based on clinical, genetic and biochemical characteristics, and most of these subtypes clinically manifest hyperextensible skin 2 . Inherited connective tissue diseases with similarities to EDS have been identified in a variety of domestic and laboratory animals 3,4 …”

Section: Introductionmentioning

confidence: 99%

Zonal dermal separation: a distinctive histopathological lesion associated with hyperelastosis cutis in a Quarter Horse

Brounts

Rashmir‐Raven

Black

2001

Veterinary Dermatology

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This case report describes a distinctive deep cutaneous lesion in a 1-year-old Quarter Horse filly with hyperelastosis cutis. The horse had a typical clinical presentation of hyperelastic skin associated with a 6-month history of cutaneous wounds that developed following minor cutaneous trauma. Punch biopsies of skin from the affected horse were thinner than similar biopsies from an age- and breed-matched control. Significant microscopic lesions were not seen in cutaneous punch biopsies stained with haematoxylin and eosin and Masson's trichrome stains, but the ultrastructure of the dermis from the affected horse was characterized by variation in collagen fibre diameter and loose packing of collagen fibres within bundles. The horse was euthanized and necropsied, and full-thickness sections of skin were collected and examined microscopically. Affected skin was of normal thickness; however, the deep dermis contained a distinctive horizontal linear zone in which separation of collagen bundles resulted in the formation of large empty cleft-like spaces between the upper and lower regions of the deep dermis. We suggest the term 'zonal dermal separation' for this microscopic lesion. Incisional full-thickness skin biopsies should be taken in suspected cases of equine hyperelastosis cutis because punch biopsies may not obtain enough deep dermis to adequately represent pathological change in the skin of horses with this disorder.

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A case of Ehlers‐Danlos‐like syndrome in a rabbit with a review of the disease in other species

Cited by 29 publications

References 20 publications

Collagen Dysplasia (Cutaneous Asthenia) in a Cat

Collagen Dysplasia (Cutaneous Asthenia) in a Cat

Dermatologic Diseases

Zonal dermal separation: a distinctive histopathological lesion associated with hyperelastosis cutis in a Quarter Horse

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