A Case of Distal Epithelioid Sarcoma of the Thumb Expressing Podoplanin, TLE1 and Ca 125

Karagkounis, G.; Argyrakos, Theodoros; Charkiolakis, G.; Castana, O; Rontogianni, D

doi:10.1155/2013/312786

Cited by 3 publications

(3 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, various sarcomas can exhibit positivity for these markers. For example, epithelioid sarcoma is usually positive for AE1/AE3 [23] and on occasion can be positive for p63 [23] and D2-40 [24,25]. However, our ultrastructural results did not show characteristics of mesothelioma (e.g.…”

Section: Discussionmentioning

confidence: 65%

Rhabdoid Carcinoma of Anal Canal: Role of Electron Microscopy and Immunohistochemistry in Establishing Lineage

Shetuni

Irtaza

Melnyk

et al. 2014

Ultrastructural Pathology

View full text Add to dashboard Cite

Rhabdoid carcinoma is a high-grade carcinoma with rhabdoid features and it is different from rhabdoid tumors that are broadly defined as malignant neoplasms with rhabdoid cellular appearance found primarily in the pediatric population, but adult cases have been reported in many anatomic locations. To date, no cases of anal canal rhabdoid carcinoma have been reported in the adult or pediatric population. We are reporting the first case of anal canal rhabdoid carcinoma, found in a 75-year-old male. We utilized ultrastructural as well as immunohistochemical studies to arrive at our diagnosis. Ultrastructural studies demonstrated the intermediate filament congregating to impart a rhabdoid appearance to tumor cells, and cytokeratin intermediate filaments and short microvilli indicating nature of tumor as carcinoma. Immunohistochemical phenotype showed neoplastic cells were positive for vimentin, pan-cytokeratin AE1/3, p63 and D2-40, which supports the genesis of tumor from skin adnexa. Even in the modern era of surgical pathology that routinely utilizes immunohistochemistry and molecular studies, adequate use of electron microscopy to help pinpoint the diagnosis in challenging cases is important.

show abstract

Section: Discussionmentioning

confidence: 65%

Rhabdoid Carcinoma of Anal Canal: Role of Electron Microscopy and Immunohistochemistry in Establishing Lineage

Shetuni

Irtaza

Melnyk

et al. 2014

Ultrastructural Pathology

View full text Add to dashboard Cite

show abstract

“…The monoclonal antibody d2-40 recognizes the membrane 40 kd sialoglycoprotein podoplanin. Podo pla nin is an established marker for germ cell tumours, mesotheliomas, Kaposi sarcoma, lymphovascular tumours, hemangioendothelioma, schwannoma, some skin tumours (Kalof and Cooper, 2009), dermatofibroma (Kaddu and Leinweber, 2009), epithelioid sarcoma (Karagkounis et al, 2013) and ependymoma (Ishizawa et al, 2009). It is also expressed in a variety of normal cells including lymphatic endothelial cells, follicular dendritic cells (Marsee et al, 2009) and myoepithelial cells of the breast (Kanner et al, 2010), chondrocytes and osteocytes (Ariizumi et al, 2010).…”

Section: Resultsmentioning

confidence: 99%

Podoplanin (D2-40) is a Reliable Marker of Urinary Bladder Myofibroblasts (Telocytes)

Povýšil,

Kaňa,

Zámečník

et al. 2014

Fol. Biol.

View full text Add to dashboard Cite

Podoplanin, D2-40, has been described in a variety of normal and neoplastic tissues. It is often used for highlighting lymphatics. We evaluated the expression of podoplanin in α-smooth muscle actinpositive myofibroblasts producing the suburothelial layer in tunica propria of the urinary bladder that have some similar features with telocytes. Our results showed that these cells demonstrate distinct D2-40 immunoreactivity from telocytes occurring in the renal pelvis and ureter. We observed positive reaction not only in bioptic specimens from women with interstitial cystitis, but also in a control group of women and men treated for pathological bladder lesion different from interstitial cystitis. It is interesting that identical staining reaction was observed in the ureters only exceptionally. In addition, we examined samples from myofibroblastic tumoriform lesions of soft tissue such as nodular fascitis and fibromatosis (desmoid) and we obtained negative results. It means that the so-called myofibroblasts of urinary bladder tunica propria have a unique immunophenotype that has probably not been described until now. Our findings suggest that D2-40 can be used as a complementary immunostainer to α-smooth muscle actin on urinary bladder biopsies from patients with interstitial cystitis. The role of D2-40 as an immunohistochemical marker is still being investigated.

show abstract

“…[2] The typical location is distal portion of the extremities, especially fingers, hand and forearm (distal/classical-type). [3] Adolescents and young adults are commonly affected. An aggressive type of ES, namely "proximal/axial" type, arises from soft tissues of pelvis, perineum and proximal extremities.…”

Section: Introductionmentioning

confidence: 99%

Epithelioid sarcoma: A case series of three different presentations

Jetly

Varadarajan

Naik

et al. 2017

CRCP

View full text Add to dashboard Cite

Background: Epithelioid sarcoma is a rare malignancy that presents diagnostic difficulties. Cases: We report three cases of epithelioid sarcoma with different presentations and clinical course. One patient had a classicaltype epithelioid sarcoma while rest two suffered from the rarer proximal-type. All three underwent surgical excision while two of them also had postoperative adjuvant therapy. The diagnostic challenges and the final outcome has been discussed in detail. Conclusion: The diagnosis of epithelioid sarcoma needs a high index of clinical suspicion and immunohistochemistry is extremely valuable. Adequacy of index surgery affects the ultimate prognosis.

show abstract

A Case of Distal Epithelioid Sarcoma of the Thumb Expressing Podoplanin, TLE1 and Ca 125

Cited by 3 publications

References 15 publications

Rhabdoid Carcinoma of Anal Canal: Role of Electron Microscopy and Immunohistochemistry in Establishing Lineage

Rhabdoid Carcinoma of Anal Canal: Role of Electron Microscopy and Immunohistochemistry in Establishing Lineage

Podoplanin (D2-40) is a Reliable Marker of Urinary Bladder Myofibroblasts (Telocytes)

Epithelioid sarcoma: A case series of three different presentations

Contact Info

Product

Resources

About