A case of definitely congenital glioblastoma manifested by intratumoral hemorrhage

Shimamura, Norihito; Asano, Kenichiroh; Ogane, Kazumi; Yagihashi, Akinori; Ohkuma, Hiroki; Suzuki, Shigeharu

doi:10.1007/s00381-003-0807-0

Cited by 26 publications

(19 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…5,6,10,12,17,18,21,[24][25][26]28,31,[33][34][35][36]41,42 From these publications, there were 29 cases of GBM that met our inclusion criteria. The patients underwent either CT scans or MRI based on the patient's age and the clinical presentation.…”

Section: Resultsmentioning

confidence: 99%

Radiological features of infantile glioblastoma and desmoplastic infantile tumors: British Columbia’s Children’s Hospital experience

Bader¹,

Heran²,

Dunham

et al. 2015

PED

View full text Add to dashboard Cite

OBJECT Two of the more common infantile brain tumors, glioblastoma multiforme (GBM) and desmoplastic infantile tumors (DITs), can be difficult to distinguish on MRI. Both tumors occur in the supratentorial compartment and both have solid and cystic components. Differentiating between the 2 on MRI studies could assist the surgeon in discussions with family and child management. The authors report on their institutional experience with both tumors, focusing on radio-graphic features, especially the diffusion studies, which might be useful in distinguishing between infantile GBM and DIT. METHODS A retrospective review was undertaken of all infantile brain tumors treated at British Columbia’s Children’s Hospital between 1982 and 2012, and cases of GBM and DIT were recorded. Only cases that had imaging were included in the study. A literature review was completed to identify reported cases of infantile GBM and DIT. Only reports that described or included radiological studies (particularly MRI) of the tumors were included. Certain radiographic features of the tumors were reviewed, including location, size, consistency, pattern of enhancement, and features on MR diffusion studies. RESULTS Of 70 cases of infantile brain tumors, 2 GBM cases and 3 DIT cases (all 3 of which were desmoplastic infantile gangliogliomas [DIGs]) met the inclusion criteria. The radiological studies obtained in all 5 cases were reviewed by a neuroradiologist. All 5 patients had supratentorial tumors with cystic-solid consistency. Diffusion MRI studies showed restricted diffusion in the 2 GBM cases, but no evidence of restricted diffusion in the DIG tumors. The GBM tumors were heterogeneously enhancing, and the DIG tumors showed avid and homogeneous enhancement. The literature review revealed 29 cases of infantile GBM and 32 cases of DIG/DIT that met the inclusion criteria. The tumors were large in both groups. The tumors were cystic-solid in consistency in 10 of 30 (33%) of GBM cases and 28 of 32 (87.5%) of DIT cases. The contrast enhancement was heterogeneous in 9 of 30 (30%) GBM cases, and it was homogeneous and avid in 27 of 32 (84%) of DIT cases. Diffusion studies were recorded in 2 published infantile GBM cases, and in both of them diffusion was restricted. The authors only found 1 report that discussed DIG tumor features on MR diffusion studies, but the interpretation was difficult and unclear. CONCLUSIONS Magnetic resonance imaging, especially diffusion-weighted imaging, may be a useful aid in distinguishing between infantile GBM and DIT tumors, with infantile GBM demonstrating restricted diffusion.

show abstract

Section: Resultsmentioning

confidence: 99%

Radiological features of infantile glioblastoma and desmoplastic infantile tumors: British Columbia’s Children’s Hospital experience

Bader¹,

Heran²,

Dunham

et al. 2015

PED

View full text Add to dashboard Cite

show abstract

“…Several cases of congenital malignant gliomas, including glioblastomas, have been reported [5,6,7,8,9,10,11,12], and some patients survived in the long term after surgical resection and chemotherapy [6, 9, 12]. Hall et al [24] described a case of anaplastic ganglioglioma in an infant who did well for 20 months after the operation without evidence of tumor recurrence on subsequent CT scans.…”

Section: Discussionmentioning

confidence: 99%

“…Solitare and Krigman [2] specified three categories of congenital brain tumors: (1) definitely congenital – present or producing symptoms at birth; (2) probably congeni tal – present or producing symptoms within the first week; (3) possibly congenital – present or producing symptoms within the first months of life. The period of 2 months, first proposed by Arnstein et al [3], is the more widely accepted limit for defining congenital brain tumors [1, 4], and several cases of congenital malignant gliomas, including glioblastomas, have been reported [5,6,7,8,9,10,11,12]. …”

Section: Introductionmentioning

confidence: 99%

Successful Chemotherapy for Congenital Malignant Gliomas: A Report of Two Cases

et al. 2006

View full text Add to dashboard Cite

We describe the cases of 2 patients with a congenital malignant glioma that responded to chemotherapy. In the first case, a 2-month-old boy had a conjugate deviation to the right side and nystagmus. A T₁-weighted gadolinium-enhanced magnetic resonance image showed a large tumor in his right frontal lobe. The tumor was partially resected, and the histological diagnosis was malignant ganglioglioma. The child then underwent 6 cycles of chemotherapy (mainly carboplatin and etoposide), and the residual tumor shrank. The tumor was then partially resected during a second operation, after which the patient underwent 5 cycles of chemotherapy (a combination of carboplatin, etoposide, vincristine, ifosfamide, cisplatin and cyclophosphamide). The tumor has not recurred in more than 8.5 years. In the second case, a 2-month-old boy had bulging of the anterior fontanel. The T₁-weighted gadolinium-enhanced magnetic resonance image showed a large suprasellar tumor. The tumor was partially resected, and the histological diagnosis was anaplastic astrocytoma. The patient underwent 8 cycles of chemotherapy (MCNU, carboplatin and etoposide) and the tumor has not recurred in more than 7.5 years. Our experience indicates that, if surgical removal and chemotherapy are done aggressively for malignant gliomas in neonates and infants, long-term survival is possible.

show abstract

“…Congenital brain tumours account for less than 2% of all pae diatric tumours. Congenital glioblastoma (cGBM) is one of the rarest types of congenital brain tumour, with less than 50 cases reported in the litera ture [13] and is uncommon in the prenatal period [17,23,33,34]. Screening methods have improved significantly prenatal detection of tumours [28].…”

Section: Introductionmentioning

confidence: 99%