A case of Crimean-Congo haemorrhagic fever in Greece, June 2008

Papa, Anna; Maltezou, Helen C.; Tsiodras, Sotirios; Dalla, Vasiliki; Papadimitriou, T; Pierroutsakos, Ioannis N.; Kartalis, G; Antoniadis, A.

doi:10.2807/ese.13.33.18952-en

Cited by 56 publications

(27 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the meantime, a cluster of CCHF cases were observed in early spring 2008 in Southwestern Bulgaria, in an area considered previously at low risk for CCHF outbreaks . In June of the same year, the first (and fatal) CCHF case was reported in Greece . The CCHFV IgG seroprevalence in Greece ranges from 0% to 14%, with age (elderly), previous tick bite, and agropastoral activities being among the major factors associated with seropositivity .…”

Section: Tick‐borne Viral Diseasesmentioning

confidence: 99%

Emerging arboviral human diseases in Southern Europe

Papa

2017

Journal of Medical Virology

View full text Add to dashboard Cite

Southern Europe is characterized by unique landscape and climate which attract tourists, but also arthropod vectors, some of them carrying pathogens. Among several arboviral diseases that emerged in the region during the last decade, West Nile fever accounted for high number of human cases and fatalities, while Crimean-Congo hemorrhagic fever expanded its geographic distribution, and is considered as a real threat for Europe. Viruses evolve rapidly and acquire mutations making themselves stronger and naive populations more vulnerable. In an effort to tackle efficiently the emerging arboviral diseases, preparedness and strategic surveillance are needed for the early detection of the pathogen and containment and mitigation of probable outbreaks. In this review, the main human arboviral diseases that emerged in Southern Europe are described.

show abstract

Section: Tick‐borne Viral Diseasesmentioning

confidence: 99%

Emerging arboviral human diseases in Southern Europe

Papa

2017

Journal of Medical Virology

View full text Add to dashboard Cite

show abstract

“…A CCHFV strain, AP92, was isolated from Rhipicephalus bursa ticks collected in 1975 from goats in Vergina village in northern Greece [9]; the seroprevalence among 64 residents of Vergina was 6.1% [10]. In June 2008, CCHF emerged in Greece when a fatal case was observed in Komotini city (Rodopi prefecture) in north‐eastern Greece [11]. The causative strain (Rodopi strain) differs genetically from the AP92 strain, which is considered as non‐pathogenic or of low pathogenicity for humans [12].…”

Section: Univariate Logistic Regression Analysis Of Crimean‐congo Hamentioning

confidence: 99%

Seroepidemiological study of Crimean-Congo haemorrhagic fever in Greece, 2009–2010

Sidira

Maltezou

Haidich

et al. 2012

Clinical Microbiology and Infection

View full text Add to dashboard Cite

To estimate endemic areas for Crimean-Congo haemorrhagic fever (CCHF) in Greece, a country-wide seroepidemiological study was conducted, and 1611 human sera were prospectively collected along with data regarding possible risk factors for acquisition of infection, and tested for CCHF virus IgG antibodies by ELISA. The overall seroprevalence was 4.2%, with significant differences among prefectures, ranging from 0 to 27.5%. Multivariate analysis revealed that slaughtering and agricultural activities were significant risk factors for CCHFV seropositivity. The significantly high seroprevalence in specific prefectures, together with the extremely low number of CCHF cases, suggest that this phenomenon might be strain-related.

show abstract

“…In a serosurvey conducted in Northern Greece, antibodies to R. conori were detected in 7.9% of the human population [10]. Here, we present a fatal MSF case in Northern Greece, which was initially considered to be one of Crimean–Congo haemorrhagic fever (CCHF): first, because the symptoms strongly resembled those of severe haemorrhagic fever and, second, because it was observed in the same region where the first confirmed Greek CCHF case was described, 45 days before [11], thus fulfilling the case definition for a probable CCHF case [12].…”

Section: Introductionmentioning

confidence: 99%

Fatal Mediterranean spotted fever in Greece

Papa

Dalla

et al. 2010

Clinical Microbiology and Infection

View full text Add to dashboard Cite

Forty-five days after the first confirmed and fatal Crimean-Congo haemorrhagic fever (CCHF) case in Greece in 2008, a female patient with similar signs and symptoms (high fever, thrombocytopaenia) and resident of the same area, was admitted to the University General Hospital of Alexandroupolis. Before admission, she had visited a local hospital where a cephalosporin was prescribed. A rash manifested over subsequent days, which was misdiagnosed as an allergy to the drug. Upon admission to the University Hospital, she was given further antibiotics, including doxycycline; a few hours later, ribavirin was added because CCHF was suspected. After the patient's death, rickettsiosis caused by Rickettsia conorii conorii (Meditteranean spotted fever; MSF) was diagnosed. Extremely high values of interleukin (IL)-1ra, IL-6, interferon-gamma-inducible protein-10, monocyte chemoattractant protein-1 and an absence of tumour necrosis factor-alpha were observed. MSF is a potentially severe and even fatal disease resembling viral haemorrhagic fevers that has to be included in the differential diagnosis of febrile syndromes combined with thrombocytopaenia, even when a tick bite is not reported, and an eschar is absent. Physicians have to be aware of MSF in patients with severe disease who are returning from the Mediterranean area.

show abstract

A case of Crimean-Congo haemorrhagic fever in Greece, June 2008

Cited by 56 publications

References 3 publications

Emerging arboviral human diseases in Southern Europe

Emerging arboviral human diseases in Southern Europe

Seroepidemiological study of Crimean-Congo haemorrhagic fever in Greece, 2009–2010

Fatal Mediterranean spotted fever in Greece

Contact Info

Product

Resources

About