A case of congenital lymphocytic choriomeningitis virus (LCMV) infection revealed by hydrops fetalis

Meritet, Jean François; Krivine, Anne; Lewin, F.; Poissonnier, Marie-Hélène; Poizat, R; Loget, Philippe; Rozenberg, Flore; Lebon, Pierre

doi:10.1002/pd.2240

Cited by 26 publications

(41 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Microcephaly, congenital hydrocephaly resulting in macrocephaly, and periventricular calcifications are often observed at birth (85). Unlike other TORCH infections and similar to ZIKV infection, signs of systemic infection, such as skin rash, thrombocytopenia, or hepatosplenomegaly, seem to be rarely observed (85,88), although some fetuses present with nonimmune hydrops fetalis (88,97). Late complications include seizures, cerebral palsy, mental retardation, and loss of vision (85).…”

Section: Lymphocytic Choriomeningitis Virusmentioning

confidence: 99%

Emerging Role of Zika Virus in Adverse Fetal and Neonatal Outcomes

et al. 2016

View full text Add to dashboard Cite

SUMMARYThe rapid spread of the Zika virus (ZIKV) in the Americas and its potential association with thousands of suspected cases of microcephaly in Brazil and higher rates of Guillain-Barré syndrome meet the conditions for a Public Health Emergency of International Concern, as stated by the World Health Organization in February 2016. Two months later, the Centers for Disease Control and Prevention (CDC) announced that the current available evidence supports the existence of a causal relationship between prenatal Zika virus infection and microcephaly and other serious brain anomalies. Microcephaly can be caused by several factors, and its clinical course and prognosis are difficult to predict. Other pathogens with proven teratogenicity have been identified long before the current ZIKV epidemic. Despite the growing number of cases with maternal signs of infection and/or presence of ZIKV in tissues of affected newborns or fetuses, it is currently difficult to assess the magnitude of increase of microcephaly prevalence in Brazil, as well as the role of other factors in the development of congenital neurological conditions. Meanwhile, health agencies and medical organizations have issued cautious guidelines advising health care practitioners and expectant couples traveling to, returning from, or living in affected areas. Analogous to dengue virus (DENV) epidemics, ZIKV has the potential to become endemic in all countries infested byAedesmosquitoes, while new mutations could impact viral replication in humans, leading to increased virulence and consequently heightened chances of viral transmission to additional naive mosquito vectors. Studies are urgently needed to answer the questions surrounding ZIKV and its role in congenital neurological conditions.

show abstract

Section: Lymphocytic Choriomeningitis Virusmentioning

confidence: 99%

Emerging Role of Zika Virus in Adverse Fetal and Neonatal Outcomes

et al. 2016

View full text Add to dashboard Cite

show abstract

“…In immunocompromised persons, LCMV exposure may result in serious systemic infections and death ( 2 ). Prenatal infection can cause spontaneous abortion or severe birth defects, including hydrocephalus, chorioretinitis, blindness, or psychomotor retardation ( 3 , 4 ). …”

mentioning

confidence: 99%

High Diversity and Ancient Common Ancestry of Lymphocytic Choriomeningitis Virus

Albariño¹,

Palacios²,

Khristova³

et al. 2010

Emerg. Infect. Dis.

View full text Add to dashboard Cite

show abstract

“…In both cases, antenatal investigation included evaluation for traditional TORCH (Toxoplasmosis, Rubella, Cytomegalovirus, Herpes, and Syphilis) infections without consideration for lymphocytic choriomeningitis virus. There are no prior reported cases of Lymphocytic choriomeningitis virus infection with fetal intracranial hemorrhage and only one prior case with non-immune hydrops fetalis (10). There are also no epidemiological studies examining the incidence of lymphocytic choriomeningitis virus infections in pregnant women or newborns.…”

Section: Discussionmentioning

confidence: 99%

“…Common sequelae of congenital lymphocytic choriomeningitis virus infection include structural cerebral anomalies, such as microcephaly, neuronal migration anomalies, periventricular calcifications, pachygyria, porencephalic cysts and periventricular cysts (1,3,5). Hydrocephalus, seizures, and subsequent neurodevelopmental disability are also common (1–6,9,10). Eye findings include chorioretinal lacunae, panretinal pigment epithelium atrophy, bilateral optic nerve dysplasia or atrophy, and reduced caliber of retinal vessels (1–5).…”

Section: Introductionmentioning

confidence: 99%

Congenital Lymphocytic Choriomeningitis Virus

et al. 2013

View full text Add to dashboard Cite

Lymphocytic Choriomeningitis Virus (LCMV) is a rodent-borne arenavirus that can cause congenital infection affecting the developing central nervous system. When the infection occurs during pregnancy, the virus targets the fetal brain and retina potentially causing ventriculomegaly, hydrocephalus, chorioretinitis, and neurodevelopmental abnormalities. It has been previously suggested that lymphocytic choriomeningitis virus be added to the list of congenital infections currently included in the TORCH acronym (Toxoplasmosis, Rubella, Cytomegalovirus, Herpes, and Syphilis). We present two neonates with antenatally known ventriculomegaly that were diagnosed with congenital lymphocytic choriomeningitis virus infection after birth. In addition to ventriculomegaly, one had non-immune hydrops fetalis and the other had intracranial hemorrhage. In view of the seroprevalence of lymphocytic choriomeningitis Virus (4.7–10%), our findings suggest that screening for congenital lymphocytic choriomeningitis virus infection should be considered in fetuses and newborns with ventriculomegaly as well as other abnormal neuroimaging findings such as intracranial hemorrhage.

show abstract

A case of congenital lymphocytic choriomeningitis virus (LCMV) infection revealed by hydrops fetalis

Cited by 26 publications

References 9 publications

Emerging Role of Zika Virus in Adverse Fetal and Neonatal Outcomes

Emerging Role of Zika Virus in Adverse Fetal and Neonatal Outcomes

High Diversity and Ancient Common Ancestry of Lymphocytic Choriomeningitis Virus

Congenital Lymphocytic Choriomeningitis Virus

Contact Info

Product

Resources

About