“…Regarding the type of treatment, 390 patients were treated with medical or other conservative treatments while 2802 patients were treated surgically; specifically, 182 patients analyzed were treated with topical 5% imiquimod cream [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 29 , 38 , 39 , 40 , 42 , 43 ], 72 with immunotherapy [ 36 ], 52 with radiotherapy [ 19 , 20 , 24 , 31 , 33 , 36 ], 32 with laser or other ablative methods [ 18 , 35 , 36 , 38 , 41 , 44 ], 23 patients with chemotherapy [ 14 , 36 ], 14 with topical 16% methyl aminolevulinate (MAL) + photodynamic therapy (PDT) [ 17 , 41 ], 10 with Fractional CO 2 Laser irradiation followed by photodynamic therapy [ 44 ], 3 with 5-fluorouracil [ 35 , 37 ] and 2 patients underwent CO 2 laser excision [ 34 ]. Among patients who underwent surgery, approximately 40% of them underwent local surgical excision [ 19 , 36 , 38 ], 31% simple partial/total vulvectomy [ 19 , 24 , 29 , 31 , 32 , 33 ,…”