A case of central diabetes insipidus in the cat: diagnosis and treatment

Burnie, A. G.; Dunn, J. K.

doi:10.1111/j.1748-5827.1982.tb01663.x

Cited by 17 publications

(12 citation statements)

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“…Twelve cats with CDI have been reported in the literature (Burnie and Dunn, 1982;Winterbotham and Mason, 1983;Kraus, 1987;Brown et al, 1993;Pittari, 1996;Aroch et al, 2005), and we have diagnosed an additional four cats at UC Davis. Thirteen of these sixteen cats were Domestic Short-or Long-Haired, two were Persian, and one was an Abyssinian.…”

Section: Central Diabetes Insipidusmentioning

confidence: 67%

Water Metabolism and Diabetes Insipidus

Nelson¹

2015

Canine and Feline Endocrinology

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Section: Central Diabetes Insipidusmentioning

confidence: 67%

Water Metabolism and Diabetes Insipidus

Nelson¹

2015

Canine and Feline Endocrinology

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“…This was true for the cat described here with the exception of mild increases in albumin and alkaline phosphatase. The elevation of serum albumin coupled with the high normal PCV (46%) may have reflected subclinical dehydration, which has been observed in other cats with DI 1–5 and may occur because of an inability to consume sufficient fluid to compensate for profound polyuria. The increase in serum alkaline phosphatase may reflect bone growth in a cat of this age 20 .…”

Section: Discussionmentioning

confidence: 91%

“…In dogs it occurs as an idiopathic condition, 16 secondary to pituitary neoplasia 16 or trauma 17 and as a congenital disorder 18 . There are few reports of central DI in cats and it has been reported to occur as an idiopathic 1–4 and congenital 5,6 condition and following trauma 7,8 …”

Section: Discussionmentioning

confidence: 99%

“…Central diabetes insipidus (DI), characterised by a partial or complete deficiency of ADH, is a rare disorder in cats. Isolated cases of feline central DI are described in the literature occurring idiopathically, 1–4 congenitally 5,6 and subsequent to trauma 7,8 and few authors describe the short term efficacy of treatment with the synthetic ADH analogue deamino‐8‐D‐arginine vasopressin (DDAVP) 4,6,8 . Here a case of trauma‐induced central DI in a cat and successful long‐term treatment with parenteral DDAVP is described.…”

mentioning

confidence: 99%

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Trauma‐induced central diabetes insipidus in a cat

Campbell

Bredhauer

2008

Aust Veterinary J

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ERRATUMThis case report was originally published in the AVJ in December 2005 ( Aust Vet J 2005;83:732 -735), but the units for deamino-8-D-arginine vasopressin (DDAVP) were incorrectly given in milligrams instead of micrograms. The paper is reprinted here in full with the correct units for DDAVP. Here a case of trauma-induced central DI in a cat and successful long-term treatment with parenteral DDAVP is described. Trauma-induced central diabetes insipidus in a cat Case reportA 1-year-old neutered male domestic shorthair cat was referred with a 4 week history of polydipsia that began immediately following a fall from an 8 m balcony. Veterinary attention was not sought at the time of the accident because, although mentation was depressed for several minutes, the cat's desire and capacity to consume water over the following hours was perceived by the owner to preclude any serious injury.Daily water intake measured by the owner for 13 consecutive days prior to presentation ranged between 900 and 1500 mL (average 1135 mL/day). Appetite was unchanged and the diet consisted predominantly of commercial tinned food supplemented with a commercial dry food and raw kangaroo meat.Upon presentation, the cat was bright and in good body condition (body condition score 6 out of 9; 9 body weight 6.2 kg). Physical examination, including complete neurological examination, was unremarkable. Urine collected by manual expression of the urinary bladder revealed no chemical abnormalities (Mulitsticks, Bayer) and USG determined by hand-held refractometer was 1.008. Haematological analysis was unremarkable. Biochemical parameters, including electrolytes, were within the reference ranges for normal cats with the exception of mild elevations in albumin (42 g/dL; reference range 27 to 38 g/dL) and alkaline phosphatase (57 IU/L; reference range < 51 IU/L). The following day a complete abdominal ultrasound examination was performed and was unremarkable. Urine was collected by antepubic cystocentesis and repeat urinalysis and urine culture was performed (Medicine and Microbiology Laboratory, University of Queensland). The urine was hyposthenuric (urine specific gravity [USG] 1.004) but otherwise unremarkable.Diabetes insipidus was suspected and a modified water deprivation test was performed (Figure 1).

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“…Congenital CDI in dogs has been reported rarely . The majority of the reported cases of CDI in cats were the result of head trauma or were idiopathic with rare reports of congenital CDI or CDI secondary to neoplasia …”

Section: Dysregulation Of Aqp2 In Diseasementioning

confidence: 99%

Aquaporin‐2 regulation in health and disease

Radin

Stoedkilde

et al. 2012

Veterinary Clinical Pathol

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Aquaporin-2 (AQP2), the vasopressin-regulated water channel of the renal collecting duct, is dysregulated in numerous water balance disorders in humans and animals including those associated with polyuria (e.g. urinary tract obstruction, hypokalemia, inflammation, and lithium toxicity) and dilutional hyponatremia (e.g. SIADH). Normal regulation of AQP2 by vasopressin involves two independent regulatory mechanisms: 1) short-term regulation of AQP2 trafficking to and from the apical plasma membrane, and 2) long term regulation of the total abundance of the AQP2 protein in the cells. Most water balance disorders are the result of dysregulation of processes that regulate the total abundance of AQP2 in collecting duct cells. In general, the level of AQP2 in a collecting duct cell is determined by a balance between production via translation of AQP2 mRNA and removal via degradation and/or secretion into the urine in exosomes. AQP2 abundance increases in response to vasopressin chiefly due to increased translation subsequent to increases in AQP2 mRNA. Vasopressin-mediated regulation AQP2 gene transcription is poorly understood, although several transcription factor binding elements in the 5’ flanking region of the AQP2 gene have been identified and candidate transcription factors corresponding to these element have been discovered in proteomics studies. Here we review progress in this area and discuss elements of vasopressin signaling in the collecting duct that may impinge on regulation of AQP2 in health and in the context of examples of polyuric diseases.

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A case of central diabetes insipidus in the cat: diagnosis and treatment

Cited by 17 publications

References 1 publication

Water Metabolism and Diabetes Insipidus

Water Metabolism and Diabetes Insipidus

Trauma‐induced central diabetes insipidus in a cat

Aquaporin‐2 regulation in health and disease

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