A Case of Carcinosarcoma of the Breast

Tokudome, Nahomi; Sakamoto, Goi; Sakai, Takehiko; Sarumaru, Syuhei; Okuyama, Naoko; Hori, Fumiko; Horii, Rie; Akiyama, Futoshi; Tanabe, Masahiko; Saito, Keita; Takahashi, Kaoru; Kasumi, Fujio

doi:10.2325/jbcs.12.149

Cited by 35 publications

(45 citation statements)

References 5 publications

(16 reference statements)

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“…Patients should be considered for routine screening in terms of metastases. Lung metastases, brain, bone and liver metastases are more frequent and the prognosis of these patients is worse (6). Tumor size, high nuclear grade, triple negative disease, lymphovascular invasion and distant metastasis are poor prognostic factors (20,21,24).…”

Section: Discussionmentioning

confidence: 99%

“…These tumors are thought to originate from malignant myofibroblasts or metaplastic differentiation of malignant epithelial cells within myofibroblasts (5). It has been reported that breast carcinosarcomas have a poor prognosis and a high risk of local-regional recurrence (6). These tumors usually do not express estrogene or progesterone receptors and HER-2/neu oncogene.…”

Section: Introductionmentioning

confidence: 99%

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Breast Carcinosarcomas

Yakan¹,

Sari²,

Erkan³

et al. 2014

J Breasth Health

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Breast Carcinosarcomas

Yakan¹,

Sari²,

Erkan³

et al. 2014

J Breasth Health

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“…52 Human breast carcinosarcomas are also rare with an incidence estimated to 0.1 to 0.2% of breast carcinomas. 53 However, they are very aggressive with a poor prognosis. True carcinosarcoma is strictly defined as a mixed tumor with both epithelial and mesenchymal components without a transition zone between the two elements.…”

Section: Discussionmentioning

confidence: 99%

Influence of Hoxa5 on p53 Tumorigenic Outcome in Mice

Gendronneau

Lemieux

Morneau

et al. 2010

The American Journal of Pathology

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Hox genes encode transcription factors of crucial importance in the pattern formation of a large spectrum of species. Several studies have now proposed a role for these developmental genes in cancer biology. It has been suggested that HOXA5 possesses growthsuppressive properties through activation of p53 expression in human breast tissue. To assess the genetic cooperation that may exist between Hoxa5 and p53 in tumorigenesis, we generated Hoxa5/p53 compound mutant mice. The presence of Hoxa5 null alleles increased the susceptibility of p53 ؊/؊ mice to develop tumors with a high prevalence for thymic lymphoma, suggesting that the loss of function of the two genes collaborate in tumor formation. To extend our analysis to mammary tumorigenesis, we performed Hoxa5/p53 whole mammary gland transplantations into wild-type hosts. In the p53 ؊/؊ background, the presence of one Hoxa5 mutant allele had no impact on mammary tumor formation. In contrast, the complete loss of Hoxa5 function influenced the tumorigenic outcome of p53 ؉/؊ mammary glands. However , the collaborative nature of this interaction did not depend on the transcriptional regulation of p53 by Hoxa5. Altogether , our data establish that Hoxa5 and p53 cooperate in mammary tumorigenesis in vivo. (Am J Pathol 2010, 176

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“…This tumor type has infrequent occurrence in dogs; it features rapid tumor growth and prolonged periods of post-surgical survival (Misdorp et al, 1999). They are rare tumors in women and have a poor prognosis compared to other carcinomas (Tokudome et al, 2005). In the dog, the clinical and pathological characteristics are similar to those described in humans (Cassali et al, 2011).…”

Section: Introductionmentioning

confidence: 59%

Cytogenetic aspects of a canine breast carcinosarcoma - a case report

Morais

Affonso²,

Bitencourt³

et al. 2017

Genet. Mol. Res.

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ABSTRACT. This study searched a rare and aggressive type of cancer in dogs and humans, the breast carcinosarcoma. Both clinical and pathological traits of mammary carcinosarcomas in dogs are similar to humans, such as infrequent occurrence, fast tumor growth, and unfavorable prognosis when compared to carcinomas. Other possible alterations include chromosomal abnormalities that can be useful for the identification of tumoral cells and diagnosis. The aim of this study was to compare the chromosomal features of peripheral lymphocytes and tumor cells in a mammary carcinosarcoma of a 14-year-old female Poodle. Chromosomes were analyzed from 210 metaphases by conventional Giemsa staining, C-banding, and base-specific fluorochrome staining with chromomycin A3 (CMA 3 + ) and DAPI. Of the 105 blood cells, 56.3% followed the standard karyotype of dogs (2n = 78). In contrast, the carcinosarcoma cells showed high chromosomal numbers (104 to 153), divided into 80% hypertriploid (118 to 136 chromosomes), 10.5% hypotetraploid (137 to 153 chromosomes), 5.7% hypotriploid (104 to 116 chromosomes), and 3.8% triploid cells (117 chromosomes). Among the aneuploid cells identified, we highlighted the trisomy of pair 1 and X chromosome once these elements were easily recognized in karyotype because of their size (pair 1) or differential morphology. Heterochromatin in normal cells was restricted to the pericentromeric region of all chromosomes while few C-bands were observed in tumor cells. This apparent loss of heterochromatin in neoplastic cells was supposed to favor centric fusion among formerly acrocentric chromosomes. Fluorochrome staining reinforced this hypothesis once GC-rich segments (CMA 3 + ) were identified on 10 chromosomes from normal cells (2n = 78) whereas carcinosarcoma metaphases had up to 11 chromosomes bearing CMA 3 signals in spite of their remarkable high chromosomal numbers. We concluded that, like in humans, the carcinosarcoma in dogs caused genome instability that eventually led to structural and numerical chromosomal aberrations. Besides, this study reinforced the importance of cytogenetic studies in dogs as a reference material for human cancer studies, especially in rare cases, since it is possible to increase knowledge about the characteristics of breast neoplasms in which there is a little availability of similar cases for comparative studies.

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A Case of Carcinosarcoma of the Breast

Cited by 35 publications

References 5 publications

Breast Carcinosarcomas

Breast Carcinosarcomas

Influence of Hoxa5 on p53 Tumorigenic Outcome in Mice

Cytogenetic aspects of a canine breast carcinosarcoma - a case report

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