A Case of Benign Metastasizing Leiomyomatosis After Uterins Arterial Embolization

Benign metastasizing leiomyoma: ‘a sheep in wolf’s clothing’

“…The lesions are histologically identical to their uterine source. 3,8,9 BML most commonly metastasizes to the lungs, 1-4,7-10 and more rarely, can metastasize to other distant sites such as the skin, bone, mediastinum, lymph nodes, muscular tissue, heart, and retroperitoneum. 2,8,9 The condition usually is detected incidentally as multiple pulmonary nodules.…”

“…The interval between hysterectomy and the appearance of pulmonary nodules can range between 3 months and 20 years. 3,[8][9][10] Symptoms of chest pain, shortness of breath, and cough have been described. Although the clinical course of the condition is usually asymptomatic, a more rapid progression to severe, and even fatal, respiratory symp-toms also has been reported.…”

“…Although the clinical course of the condition is usually asymptomatic, a more rapid progression to severe, and even fatal, respiratory symp-toms also has been reported. [1][2][3][6][7][8][9] The clinical course of patients with BML varies and seems to depend on the estrogen status of the patient and the course of the disease may be more progressive in premenopausal patients than it is in postmenopausal patients. 10 There has been much debate about the nature of this lesion, a tumor with benign histological features but having biological behavior that suggests malignancy.…”

“…enign metastasizing leiomyoma (BML) is a rare entity, [1][2][3][4][5][6][7][8][9] of which a small number of cases, about 75 1,4,6 to 120, [8][9][10] have been described in the literature since the condition was first described in 1939. It usually affects women of reproductive age with a history of uterine leiomyomatosis who have undergone a hysterectomy.…”

“…3,6 The lung is the most common site of involvement. [1][2][3][4][7][8][9] The pathologic features of this entity are described as having originated from the metastasis of the histologically benign uterine leiomyoma and are an uncommon lesion characterized by the presence of multiple smooth-muscle nodules that are often located in the lung, lymph nodes, or abdomen. 2 Although these lesions are slow growing and asymptomatic and are usually incidentally diagnosed, they may rarely cause debilitating symptoms.…”