Benign metastasizing leiomyoma: ‘a sheep in wolf’s clothing’

Sehgal, Rajesh; Maghrabi, Adam H.

doi:10.12788/j.cmonc.0006

Cited by 4 publications

(1 citation statement)

References 11 publications

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“…About 120 cases have been described in the literature, most of them involving the lungs as common site of metastasis [3][4][5][6]. We www.clinicalcases.eu 243 Arch Clin Cases 2015; 2 (4):242-251 present a brief review of the literature along with a report of a rare case of pulmonary BML.…”

Section: Introductionmentioning

confidence: 99%

Benign metastasizing leiomyoma of the lung – case report and brief review of the literature

Afrăsânie¹,

Iacob²,

Ferariu³

et al. 2015

Arch Clin Cases

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Benign metastasizing leiomyoma is a rarely described disease characterized by extrauterine leiomyomatous lesions seen in premenopausal women with a history of uterine leiomyoma. Here, we present the case of a 47 year-old female who has undergone total hysterectomy for uterine leiomyoma at the age of 35. In 2012, eleven years after the hysterectomy, multiple pulmonary nodular lesions and a left ovary cyst were incidentally discovered during routine medical investigations. She underwent left salpingo-oophorectomy and resection of the pulmonary metastases. The histological and immunohistochemical findings led to the diagnosis of benign metastasizing leiomyoma. During 3 years of observation after the diagnosis was established, she presented with progressive disease, although she was under medroxyprogesterone acetate therapy. The therapy was substituted with aromatase inhibitors and the disease became stable. We present this case due to the rarity of this condition and also because it is a rare clinical presentation with an interesting therapeutic strategy.

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Section: Introductionmentioning

confidence: 99%

Benign metastasizing leiomyoma of the lung – case report and brief review of the literature

Afrăsânie¹,

Iacob²,

Ferariu³

et al. 2015

Arch Clin Cases

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A Case of Simultaneous Benign Metastasizing Leiomyomas and Disseminated Peritoneal Leiomyomatosis Following Endoscopic Power Morcellation for Uterine Disease

Park

Leslie²,

Chen³

et al. 2017

Female Pelvic Med Reconstr Surg

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Extrauterine spread of leiomyomas is rare and most commonly occurs in the lungs. We present a case of simultaneous metastatic leiomyomatosis to the lungs and peritoneal cavity following laparoscopic myomectomy with power morcellation. The patient presented to our institution for further management where she underwent a robotically assisted hysterectomy with bilateral salpingo-oophorectomy. Leiomyomatous implants measuring up to 2.4 cm were resected from bowel mesentery and bladder peritoneum. Subsequent serial computed tomography imaging confirmed stable pulmonary nodules without new intraperitoneal lesions. Increasing number of cases involving extrauterine spread of leiomyomas has been reported with the introduction of power morcellation. The exact pathogenesis is unknown but is likely multifactorial. We emphasize that although the incidence of spread of benign disease is low, it is important to recognize this phenomenon as we will likely continue to encounter similar cases in the coming years.

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Unilateral primary ovarian leiomyoma masqueraded as ovarian fibroma

Bharti

Khera

Sharma

et al. 2021

Journal of Family Medicine and Primary Care

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Leiomyoma is the commonest benign mesenchymal tumor of the uterus, which can be developed at any site where smooth muscle cells are found. The broad ligament is the most common and ovary is one of the rarest extrauterine sites, accounting for 0.5–1% of all benign ovarian tumors. Herein, we report a case of ovarian leiomyoma in a perimenopausal female, clinically presented with heavy menstrual bleed, radiologically diagnosed as subserosal uterine fibroid. Intraoperatively, it was considered as ovarian fibroma but finally diagnosed as ovarian leiomyoma on histomorphology, which was confirmed on special stains and immunohistochemistry. A review of literature showed that less than 100 cases of primary ovarian leiomyomata have been reported until now. Ovarian leiomyoma is usually small, asymptomatic, and an incidental finding mostly, usually synchronously seen with uterine leiomyoma. Ovarian leiomyoma is a rare tumor, often misdiagnosed prior to surgical removal and it should be differentiated from other spindle cell neoplasm and solid tumors of the ovary.

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Benign metastasizing leiomyoma: ‘a sheep in wolf’s clothing’

Cited by 4 publications

References 11 publications

Benign metastasizing leiomyoma of the lung – case report and brief review of the literature

Benign metastasizing leiomyoma of the lung – case report and brief review of the literature

A Case of Simultaneous Benign Metastasizing Leiomyomas and Disseminated Peritoneal Leiomyomatosis Following Endoscopic Power Morcellation for Uterine Disease

Unilateral primary ovarian leiomyoma masqueraded as ovarian fibroma

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