A Case of Acute Gastric Mucosal Lesions Associated with <i>Helicobacter heilmannii</i> Infection

Yoshimura, Masaya; Isomoto, Hajime; Shikuwa, Saburo; Osabe, Masayuki; Matsunaga, Keiichiro; Omagari, Katsuhisa; Mizuta, Yohei; Murase, Kunihiko; Murata, Ikuo; Kohno, Shigeru

doi:10.1046/j.1523-5378.2002.00103.x

Cited by 30 publications

(31 citation statements)

References 24 publications

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“…is rare, but is known to be associated with chronic active gastritis, peptic ulcers, and lowgrade mucosa-associated lymphoid tissue lymphoma in humans (Morgner et al 2000;Yoshimura et al 2002;Van den Bulck et al 2005;Alon et al 2010). In contrast to H. pylori, various Helicobacter species colonise the stomachs of domestic animals, which might be a reservoir for transmission to humans.…”

Section: Discussionmentioning

confidence: 99%

Eradication of gastric Helicobacter spp. by triple therapy in dogs

Mirzaeian¹,

Sarchahi²,

Tabrizi³

et al. 2013

Vet. Med. - Czech

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ABSTRACT:The aim of this study was to determine the efficacy of a triple anti-Helicobacter therapy using omeprazole, amoxicillin and clarithromycin (OAC) in dogs. A total of 15 healthy adult stray dogs with naturally acquired Helicobacter infection were evaluated using polymerase chain reaction and rapid urease test. Subsequently, they received a 21-day triple regimen. One day after the discontinuation of treatment, a second molecular analysis of gastric biopsies revealed complete eradication of Helicobacter DNA with negative quantitative urease testing in all 15 dogs. Our results confirmed the high prevalence of gastric Helicobacter-like organisms (GHLOs) in the stray dog population of Shiraz, Iran, and the effectiveness of our therapeutic regimen for the complete eradication of these microorganisms in stray dogs. In conclusion, for the complete elimination of non-pylori Helicobacter spp. from the gastric mucosa of dogs, a 21-day three-drug regimen with omeprazole, amoxicillin and clarithromycin is suggested.

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Section: Discussionmentioning

confidence: 99%

Eradication of gastric Helicobacter spp. by triple therapy in dogs

Mirzaeian¹,

Sarchahi²,

Tabrizi³

et al. 2013

Vet. Med. - Czech

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“…The lesions, however, appear less severe than those associated with H. pylori (216). Acute gastritis is also occasionally observed (246). There may be glandular atrophy or intestinal metaplasia of the fundic mucosa, but these lesions are less common with non-H. pylori Helicobacter than with H. pylori infections (216).…”

Section: Gastric Disease In Humans Infected With Non-h Pylori Helicomentioning

confidence: 99%

“…There may be glandular atrophy or intestinal metaplasia of the fundic mucosa, but these lesions are less common with non-H. pylori Helicobacter than with H. pylori infections (216). Gastric erosions located mainly in the antrum (22,41,50,199,221,246) and duodenal ulcers (21,81,118,194) have also been reported in association with non-H. pylori Helicobacter infections. Furthermore, these infections have been associated with low-grade MALT lymphoma of the stomach, and the risk of developing MALT lymphoma is higher with non-H. pylori helicobacters than with H. pylori (153,154).…”

Section: Gastric Disease In Humans Infected With Non-h Pylori Helicomentioning

confidence: 99%

“…Other aspecific symptoms include hematemesis, recurrent dyspepsia, irregular defecation frequency and consistency, vomiting, heartburn, and dysphagia, often accompanied by a decreased appetite (50,81,101,123,148,164,194,199,221,235,238,245,246). Some people infected with non-H. pylori helicobacters do not present obvious clinical signs (142).…”

Section: Gastric Disease In Humans Infected With Non-h Pylori Helicomentioning

confidence: 99%

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Gastric Helicobacters in Domestic Animals and Nonhuman Primates and Their Significance for Human Health

et al. 2009

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SUMMARY Helicobacters other than Helicobacter pylori have been associated with gastritis, gastric ulcers, and gastric mucosa-associated lymphoid tissue lymphoma in humans. These very fastidious microorganisms with a typical large spiral-shaped morphology were provisionally designated “H. heilmannii,” but in fact they comprise at least five different Helicobacter species, all of which are known to colonize the gastric mucosa of animals. H. suis, which has been isolated from the stomachs of pigs, is the most prevalent gastric non-H. pylori Helicobacter species in humans. Other gastric non-H. pylori helicobacters colonizing the human stomach are H. felis, H. salomonis, H. bizzozeronii, and the still-uncultivable “Candidatus Helicobacter heilmannii.” These microorganisms are often detected in the stomachs of dogs and cats. “Candidatus Helicobacter bovis” is highly prevalent in the abomasums of cattle but has only occasionally been detected in the stomachs of humans. There are clear indications that gastric non-H. pylori Helicobacter infections in humans originate from animals, and it is likely that transmission to humans occurs through direct contact. Little is known about the virulence factors of these microorganisms. The recent successes with in vitro isolation of non-H. pylori helicobacters from domestic animals open new perspectives for studying these microorganisms and their interactions with the host.

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“…A limited number of human gastric biopsy samples, however, were shown to harbor bacteria which were morphologically different from H. pylori (6,19). These tightly coiled bacteria were mostly associated with chronic active gastritis characterized by an inflammatory process less intense than that of H. pylori-related gastritis (6,19,37), and sporadic cases of gastric ulcers or erosions (7,10,38,43) and cancer (29,42) were also reported. Genetically and morphologically based studies directed the classification of the helical organisms into the genus Helicobacter, and the provisional name "Helicobacter heilmannii" was proposed (34).…”

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confidence: 99%

Identification of Non- Helicobacter pylori Spiral Organisms in Gastric Samples from Humans, Dogs, and Cats

et al. 2005

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Tightly coiled bacteria are a rare cause of gastric pathology in humans and represent a mixture of species for which a zoonotic origin is suspected. Similar organisms are common inhabitants of the gastric mucosae of carnivores and pigs. It was the goal of the present study to determine the actual occurrence of each individual Helicobacter species in human, canine, and feline stomachs in order to better understand the possible zoonotic significance. Gastric biopsy samples from humans with histological evidence of non-Helicobacter pylori spiral bacteria (n ‫؍‬ 123) and samples from the gastric antrum, corpus, and cardia from dogs (n ‫؍‬ 110) and cats (n ‫؍‬ 43) were subjected to a multiplex PCR, enabling the identification of Helicobacter felis, Helicobacter bizzozeronii, Helicobacter salomonis, and "Candidatus Helicobacter suis." A PCR for detecting H. pylori was applied to all human samples. Single infections with "Candidatus Helicobacter suis," H. felis, H. bizzozeronii, H. salomonis, a hitherto unknown genotype of a non-H. pylori spiral organism (Helicobacter-like organism 135 [HLO135]), and H. pylori were identified in 30.9%, 8.9%, 2.4%, 11.4%, 7.3%, and 8.9% of the human biopsy samples, respectively. Mixed infections (16.3%) with two or even three of these were also found. In the canine stomach, H. bizzozeronii (70.0%) was encountered as the main spiral organism, while H. felis (62.7%) and HLO135 (67.4%) were the predominant Helicobacter species found in the feline gastric mucosa. Although the majority of human non-H. pylori organisms are Helicobacter species naturally occurring in the stomachs of pigs, cats, and dogs, the frequent identification of H. salomonis in human gastric biopsy samples is in contrast to its rare identification in pet carnivore samples, urging us to suspect other sources of infection. Spiral organisms have been described in the gastric mucosae of cats and dogs since the 19th century and are considered common inhabitants of the gastric mucosal niche (18). Three different morphological types were identified after ultrastructural analyses of the bacteria in situ; these types originally were presumed to represent various stages in the movement of one organism (25). Recent polyphasic taxonomy studies involving various isolates, however, revealed at least three different species belonging to the genus Helicobacter, namely, Helicobacter felis (24), Helicobacter bizzozeronii (17), and Helicobacter salomonis (21); these species are both phenotypically and phylogenetically highly related (21). These tightly coiled organisms were largely ignored by the scientific community until the isolation of Helicobacter pylori from the human gastric mucosa renewed interest in gastric bacteria (27).H. pylori, colonizing the stomachs of half of the world's human population, was proved to be the primary cause of gastritis and peptic ulceration (13) and is considered a major risk factor in the development of gastric adenocarcinoma (32) and mucosa-associated lymphoid tissue lymphoma (36). A limited number of hum...

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A Case of Acute Gastric Mucosal Lesions Associated with Helicobacter heilmannii Infection

Cited by 30 publications

References 24 publications

Eradication of gastric Helicobacter spp. by triple therapy in dogs

Eradication of gastric Helicobacter spp. by triple therapy in dogs

Gastric Helicobacters in Domestic Animals and Nonhuman Primates and Their Significance for Human Health

Identification of Non- Helicobacter pylori Spiral Organisms in Gastric Samples from Humans, Dogs, and Cats

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