A Case of a Schwannoma of the Esophagus Showing High Radiotracer Concentration in FDG-Pet

Ota, Masaho; Nakamura, Tsutomu; Oguma, Hidetoshi; Narumiya, Kosuke; Kudo, Kenji; Yamamoto, Masakazu

doi:10.3919/jjsa.68.49

Cited by 11 publications

(2 citation statements)

References 12 publications

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“…FDG-PET imaging is increasingly being used in the field of clinical oncology because it enables the functional imaging of viable tumor tissue [4]. To date there have been five reported cases of esophageal schwannoma with FDG-PET findings, including the present cases [5][6][7]. All of the presented cases were histologically benign esophageal schwannomas that were FDG-positive (Table 1).…”

Section: Discussionmentioning

confidence: 77%

Two cases of benign esophageal schwannoma with positive FDG-PET findings

et al. 2011

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We report two cases of rare benign esophageal schwannoma showing high uptake of radiotracer on [ 18 F]fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET). Case 1 was a 78-year-old woman with a tumor (50 9 30 9 30 mm) located on the right side of the upper thoracic esophagus. Case 2 was a 70-year-old woman with a tumor (40 9 35 9 27 mm) located in the left anterior wall of the thoracic-to-cervical esophagus. Both tumors were enucleated and histologically diagnosed as benign esophageal schwannoma with nuclear palisading and lymphoid cuffing (Antoni A type). Immunohistochemical staining showed positivity for S-100 protein.There have been five reported cases of esophageal schwannoma with FDG-PET findings, including the present two cases. All five tumors were FDG-PET positive and presented histologically as benign esophageal schwannoma. There was no association between histological malignancy and FDG uptake. We therefore propose that the malignant potential of esophageal schwannomas cannot be evaluated using FDG-PET.

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Section: Discussionmentioning

confidence: 77%

Two cases of benign esophageal schwannoma with positive FDG-PET findings

et al. 2011

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“…b, c The tumor was enucleated from the proper muscle of the esophagus, preserving the integrity of the submucosa. d The myotomy was closed by handsewing to prevent a diverticulum at the resection site a b There is only one previous case report of a benign esophageal schwannoma with high uptake of FDG [7]. On the other hand, some investigators demonstrated high accumulation of FDG was found in schwannomas in locations other than the esophagus.…”

Section: Discussionmentioning

confidence: 99%

A case of thoracoscopically resected benign esophageal schwannoma with high uptake on FDG-PET

et al. 2008

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We report a rare case of esophageal schwannoma with high uptake of radiotracer on [ 18 F]fl uoro-2-deoxy-Dglucose positron emission tomography (FDG-PET). A 37-year-old woman underwent surgery for sarcoma of the uterus and received general PET examination for postoperative follow-up, which revealed high uptake at the thoracic esophagus. Esophagography, esophageal endoscopy, endoscopic ultrasonography, and computed tomography (CT) scan confi rmed a submucosal tumor, about 20 mm in diameter, in the right wall of the upper thoracic esophagus. We performed thoracoscopic enucleation with the preoperative diagnosis of esophageal leiomyoma or gastrointestinal stromal tumor (GIST). Histopathological examination showed a trabecular arrangement of spindle cells and no evidence of mitosis. Immunohistochemical studies were positive for S-100 protein and negative for c-kit, whereby we diagnosed a benign esophageal schwannoma. Even if benign, schwannomas often show high uptake of FDG, so that the evaluation of whether the tumor is malignant should be made by histological diagnosis. Thoracoscopic resection is less invasive and a clinically useful approach to treat such submucosal tumors of the esophagus.

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