A Case of a Large Cell Neuroendocrine Carcinoma of the Thymus

Nishizawa, Natsumasa; Osaki, Toshihiro; Kanayama, Masatoshi; Nakagawa, Makoto; Saito, Tomoko; Kodate, Mantaro

doi:10.2482/haigan.55.1092

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…It has been reported that thymic LCNEC is a heterogeneously enhanced tumor on chest CT [ 9 , 12 , 17 , 19 – 21 ]. There have been only a few reports about the MRI and FDG-PET findings of thymic LCNECs.…”

Section: Discussionmentioning

confidence: 99%

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Resected thymic large cell neuroendocrine carcinoma: report of a case

et al. 2018

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BackgroundThymic large cell neuroendocrine carcinoma (LCNEC) is extremely rare. The detailed clinical features of thymic LNCECs remain unknown.Case presentationA 90-year-old man with a history of diabetes mellitus, chronic renal failure, and an abdominal aortic aneurysm underwent computed tomography for follow-up, which showed an anterior mediastinal tumor, measuring 31 mm × 28 mm in diameter. Magnetic resonance imaging showed an iso-intensity mass on T1-weighted images and high intensity on T2-weighted images. 18F-Fluorodeoxyglucose-positron emission tomography showed marked uptake in the mass, which was diagnosed as invasive thymoma or thymic carcinoma. Video-assisted thoracic surgery through the left thoracic cavity was converted to median sternotomy due to severe adhesions between the left lung and the chest wall. Partial thymectomy and combined partial resection of left upper lobectomy and the first and the second costal cartilages were performed. The pathologic diagnosis was thymic LCNEC, Masaoka stage III. The patient developed pleural dissemination and left lung metastases in 5 months and died 12 months after surgery.ConclusionsThymic LCNEC has high malignant potential. More cases need to be studied.

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Section: Discussionmentioning

confidence: 99%

“…There have been only a few reports about the MRI and FDG-PET findings of thymic LCNECs. Reported MRI findings included iso- to high intensity on T1-weighted imaging and low-intensity on T2-weighted imaging [ 10 , 13 , 19 ]. The SUVmax of thymic LCNEC was reported to be very high, 13.5 [ 17 ], 17.1 [ 21 ], and 20.7 [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Resected thymic large cell neuroendocrine carcinoma: report of a case

et al. 2018

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Large Cell Neuroendocrine Carcinoma of the Mediastinum Successfully Treated with Systemic Chemotherapy after Palliative Radiotherapy

et al. 2019

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Large cell neuroendocrine carcinoma (LCNEC) is a highly malignant cancer originally found in lung in 1991. In extremely rare occasions, primary LCNEC is found in the mediastinum; approximately 40 of such cases have been reported. Due to the limited number of reported cases, a standardized treatment protocol has yet to be established. We report a case of a 66-year-old woman with primary mediastinal LCNEC who presented with superior vena cava syndrome. Emergent radiotherapy was performed, followed by systemic chemotherapy with cisplatin and etoposide, which resulted in a dramatic tumor reduction. This is the first report describing the achievement of a complete response after systemic chemotherapy in a patient with primary LCNEC.

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