A Case of a Five-Year-Old Boy With Acute Retinal Necrosis

Iino, Y.; Tanaka, Minoru; Hatano, Noriko; Kiyokawa, Masatoshi; Takebayashi, Hiroshi; Shinohara, Izumi; Kobayashi, Yasuhiko; Ninomiya, Hisako

doi:10.1097/00006982-200204000-00018

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…Ocular manifestations of chickenpox are usually limited to the appearance of vesicles on the eyelids, conjunctiva, and limbus; most complications involve the anterior segment of the eye and resolve without permanent visual sequelae 1. However, the clinical spectrum of ocular involvement associated with primary VZV infection varies greatly, and ranges from mild anterior uveitis to severe, potentially sight‐threatening complications such as acute retinal necrosis (ARN) 1,4–14,21. Retinitis, though rare, may result in substantial morbidity 4–6.…”

Section: Discussionmentioning

confidence: 99%

“…In children with varicella (chickenpox) 1, anterior uveitis resulting in mild inflammation occurs up to 25%, though serious ocular disease, especially involving the posterior segment, is unusual 2,3. Outside of the ophthalmologic literature 4–13, only one report of VZV‐associated retinitis has been reported in the pediatric literature 14. In children with cancer 15–17, atypical clinical presentations and unusual complications of varicella can pose diagnostic and therapeutic challenges 18,19.…”

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Retinitis following varicella in a vaccinated child with acute lymphoblastic leukemia

Ross

McLean

Farber

et al. 2005

Pediatr. Blood Cancer

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Serious ocular disease following varicella (chickenpox) is rare in children. In addition, retinitis in children with hematologic malignancies may present a difficult diagnostic challenge because infectious retinitis may mimic leukemic involvement of the eye. We report a 7-year-old patient with T-cell acute lymphoblastic leukemia in remission who presented with visual complaints 2 weeks after developing chickenpox. Ophthalmologic evaluation revealed acute retinitis in the right eye. Prolonged therapy with acyclovir resulted in near complete recovery. Early diagnosis of VZV retinopathy and aggressive antiviral treatment is critical to prevent acute and long-term ocular sequelae.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Retinitis following varicella in a vaccinated child with acute lymphoblastic leukemia

Ross

McLean

Farber

et al. 2005

Pediatr. Blood Cancer

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A 9 Year-Old Girl with Herpes Simplex Virus Type 2 Acute Retinal Necrosis Treated with Intravitreal Foscarnet

King

Chung

DiLoreto

2007

Ocular Immunology and Inflammation

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A 9-year-old girl presented with a 2-week history of redness in the left eye. Examination revealed vitritis, retinal whitening, vasculitis, and optic nerve head edema. Polymerase chain reaction testing of the aqueous fluid revealed herpes simplex virus type 2. The retinitis was controlled with intravenous acyclovir and intravitreal foscarnet. The clinical course was complicated by retinal neovascularization and vitreous hemorrhage, which was treated by pars plana vitrectomy and endolaser. While there are few case reports of herpes simplex virus type 2 retinitis in children, this one is unique for the following reasons: it is the first reported case of herpes simplex virus type 2 retinitis in a child less than 10 years old without a previous history of neonatal infection or central nervous system involvement; no other children have been reported to have been treated with intravitreal foscarnet; and retinal neovascularization complicated the recovery.

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