Acute Retinal Necrosis and Cystic Encephalomalacia in a Premature Neonate

Wong, Ryan; Khanifar, Aziz A.; Sun, Grace; Heier, Linda; Saffra, Norman; Chan, Robison Vernon Paul

doi:10.1097/icb.0b013e3181ad3900

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…To our best knowledge, this is the first report of a case of combined ARN . In contrast to pediatric or adult cases, neonatal case series postulate that HSVmediated ARN is a primary infection rather than a viral reactivation because neonates would not yet have acquired immunity to HSV 14,15) . There has been much focus on HSV encephalitis in neonatal HSV infection.…”

Section: Introductionmentioning

confidence: 99%

Bilateral Acute Retinal Necrosis and Encephalomalacia Due to Herpes Simplex Virus Infection in a Premature Infant

et al. 2019

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Herpes simplex virus (HSV) is a common pathogen, that causes a broad spectrum of diseases, ranging from minor skin infections to severe encephalitis and widespread infections. Acute retinal necrosis (ARN), one of the most serious manifestations of HSV infection, is defined as a rapidly progressing necrotizing retinopathy that pre sents discrete areas of circumferential retinal necrosis, along with signs of uveitis, vitreitis, and retinal vasculitis. We encountered a case of a female infant, born at 33 weeks of gestation with a body weight at birth of 2,080 g, who had ARN and encepha lomalacia due to HSV infection. ARN associated with HSV infection should be sus pected when nonspecific retinal exudates are observed in neonates, especially preterm infants.

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Section: Introductionmentioning

confidence: 99%

Bilateral Acute Retinal Necrosis and Encephalomalacia Due to Herpes Simplex Virus Infection in a Premature Infant

et al. 2019

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Acute Retinal Necrosis Secondary to Herpes Simplex Virus Type 2 in Neonates

Venincasa¹,

Emanuelli²,

Leng³

et al. 2015

Ophthalmic Surg Lasers Imaging Retina

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Acute retinal necrosis (ARN) should be in the differential diagnosis of a neonate who presents with vitritis. This report includes three cases of neonatal ARN at the Bascom Palmer Eye Institute from 2004 to 2009. Medical treatment with acyclovir helped reduce sequelae of herpes simplex virus (HSV) 2 infection. Patients with ARN are at risk for retinal detachment and blindness. Although mothers are screened during pregnancy, they are at risk of reactivation or primary contraction of HSV. A neonate presenting with vitritis should raise suspicion of ARN.

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Acute Retinal Necrosis and Cystic Encephalomalacia in a Premature Neonate

Abstract: To our knowledge, this is the youngest reported patient with ARN. This case demonstrates that neonatal ARN may present with posterior chorioretinal lesions and highlights the importance of considering HSV infection of the central nervous system with MRI findings of cystic encephalomalacia.

Cited by 2 publications

References 8 publications

Bilateral Acute Retinal Necrosis and Encephalomalacia Due to Herpes Simplex Virus Infection in a Premature Infant

Bilateral Acute Retinal Necrosis and Encephalomalacia Due to Herpes Simplex Virus Infection in a Premature Infant

Acute Retinal Necrosis Secondary to Herpes Simplex Virus Type 2 in Neonates

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