A Case of 2019 Novel Coronavirus in a Pregnant Woman With Preterm Delivery

Wang, Xiaotong; Zhou, Zhiqiang; Zhang, Jianping; Zhu, Fengcai; Tang, Yongyan; Shen, Xinghua

doi:10.1093/cid/ciaa200

Cited by 333 publications

(497 citation statements)

References 10 publications

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“…So far, few reports have provided information on the clinical and imaging follow up of pregnant patients with COVID-19. Although, no mortality has been reported among their patients [4][5][6].…”

Section: Introductionmentioning

confidence: 95%

WITHDRAWN: Mortality of a pregnant patient diagnosed with COVID-19: A case report with clinical, radiological, and histopathological findings

Karami

Naghavi

Feyzi

et al. 2020

Travel Medicine and Infectious Disease

128

209

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This report highlights details on a pregnant case of COVID-19 who unfortunately did not survive. This 27-yearold woman at her 30 and 3/7 weeks' gestation was referred to our center with fever, myalgia, and cough. The laboratory investigations showed leukopenia and lymphopenia as well as increased creatinine and CRP levels. The first chest X-ray (faint bilateral patchy opacities) and CT scan (some faint subpleural ground-glass opacities associated with pleural thickening) were not typical for initial COVID-19 pulmonary infection, however, the treatment for COVID-19 was started. Due to respiratory distress, she was intubated and put under mechanical ventilation. After a while, the fetus was born with Apgar score of 0 and did not react to the neonatal cardiopulmonary resuscitation protocol. Finally, due to deterioration in the clinical and imaging findings, the patient was expired as a result of multi-organ failure. Following the death, autopsy was performed and the histopathologic evaluations of the lungs showed evidence of viral pneumonia (viral cytopathic effect and a mild increase in alveolar wall thickness) and ARDS (hyaline membrane). Also, reverse transcription-polymerase chain reaction (RT-PCR) confirmed SARS-CoV-2 infection in the lungs. To our knowledge, this is the first report of maternal death with confirmed COVID-19 infection.

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Section: Introductionmentioning

confidence: 95%

WITHDRAWN: Mortality of a pregnant patient diagnosed with COVID-19: A case report with clinical, radiological, and histopathological findings

Karami

Naghavi

Feyzi

et al. 2020

Travel Medicine and Infectious Disease

128

209

View full text Add to dashboard Cite

show abstract

“…There is no evidence that the virus can be transmitted vertically from the mother to the fetus during pregnancy. This is based on; one study of 9 pregnant women with laboratory-confirmed COVID-19 pneumonia [8];a single case report [9]; a study of 41 pregnant women with confirmed COVID-19 [11]; and a study of 15 pregnant women with COVID-19 [10].…”

Section: Clinical Findingsmentioning

confidence: 99%

COVID-19 and maternal mental health: Are we getting the balance right?

Topalidou

Thomson

Downe

2020

Preprint

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This paper presents a rapid evidence review into the clinical and psychological impacts of COVID-19 on perinatal women and their infants. Literature search revealed that there is very little formal evidence on the impact of COVID-19 on pregnant, labouring and postnatal women or their babies. The clinical evidence to date suggests that pregnant and childbearing women, and their babies are not at increased risk of either getting infected, or of having severe symptoms or consequences than the population as a whole. There is no evidence on the short-and longer-term psychological impacts of restrictive practices or social and personal constraints for childbearing women during COVID-19 in particular, or infection pandemics in general. The potential for adverse mental health consequences of the pandemic should be recognised as a critical public health concern, together with appropriate care and support to prevent and ameliorate any negative impacts.

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“…9/10 infants were tested for COVID-19, all testing was negative. Wang et al reported a baby born at 30 weeks in good condition with an uneventful neonatal course (2). SARS 4/16 pregnancies not affected by miscarriage resulted in pre-term delivery, at 26, 28, 32 and 33 weeks gestation (4,6,7,19,21).…”

Section: Covid-19mentioning

confidence: 99%

“…The indication for delivery is not reported however 6 babies were affected by fetal distress prior to delivery-it seems reasonable to assume that fetal condition contributed. Wang et al report one woman who was delivered at 30 weeks for fetal distress (2). SARS 4/16 pregnancies not affected by miscarriage resulted in pre-term delivery, at 26, 28, 32 and 33 weeks gestation (18), data on timing of delivery is not reported in the series of 5 women from Zhang et al (19).…”

mentioning

confidence: 99%

Coronavirus in pregnancy and delivery: rapid review and expert consensus

Mullins

Evans²,

Viner³

et al. 2020

Preprint

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BACKGROUND Person to person spread of COIVD-19 in the UK has now been confirmed. There are limited case series reporting the impact on women affected by coronaviruses (CoV) during pregnancy. In women affected by SARS and MERS, the case fatality rate appeared higher in women affected in pregnancy compared with non-pregnant women. We conducted a rapid, review to guide management of women affected by COVID -19 during pregnancy and developed interim practice guidance with the RCOG and RCPCH to inform maternity and neonatal service planning METHODS Searches were conducted in PubMed and MedRxiv to identify primary case reports, case series, observational studies or randomised-controlled trial describing women affected by coronavirus in pregnancy and on neonates. Data was extracted from relevant papers and the review was drafted with representatives of the RCPCH and RCOG who also provided expert consensus on areas where data were lacking RESULTS From 9964 results on PubMed and 600 on MedRxiv, 18 relevant studies (case reports and case series) were identified. There was inconsistent reporting of maternal, perinatal and neonatal outcomes across case reports and series concerning COVID-19, SARS, MERS and other coronaviruses. From reports of 19 women to date affected by COVID-19 in pregnancy, delivering 20 babies, 3 (16%) were asymptomatic, 1 (5%) was admitted to ICU and no maternal deaths have been reported. Deliveries were 17 by caesarean section, 2 by vaginal delivery, 8 (42%) delivered pre-term. There was one neonatal death, in 15 babies who were tested there was no evidence of vertical transmission.CONCLUSIONS Morbidity and mortality from COVID-19 appears less marked than for SARS and MERS, acknowledging the limited number of cases reported to date. Pre-term delivery affected 42% of women hospitalised with COVID-19, which may put considerable pressure on neonatal services if the UK reasonable worse-case scenario of 80% of the population affected is realised. There has been no evidence of vertical transmission to date. The RCOG and RCPCH have provided interim guidance to help maternity and neonatal services plan their response to COVID-19.BACKGROUND The common human coronaviruses; 1. 229E (alpha coronavirus), 2. NL63 (alpha coronavirus), 3. OC43 (beta coronavirus) and 4. HKU1 (beta coronavirus) cause the common cold. Three human coronaviruses cause more severe, acute illnesses; MERS-CoV causes Middle East Respiratory Syndrome, MERS, SARS-CoV causes severe acute respiratory syndrome, or SARS and SARS-CoV-2 coronavirus that causes COVID-19.There are limited case series reporting the impact on women affected by coronaviruses (CoV) during pregnancy. In women affected by SARS and MERS, the case fatality rate appeared higher in women affected in pregnancy compared with non-pregnant women.

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A Case of 2019 Novel Coronavirus in a Pregnant Woman With Preterm Delivery

Abstract: We presented a case of a 30-week pregnant woman with COVID-19 delivering a healthy baby with no evidence of COVID-19.

Cited by 333 publications

References 10 publications

WITHDRAWN: Mortality of a pregnant patient diagnosed with COVID-19: A case report with clinical, radiological, and histopathological findings

WITHDRAWN: Mortality of a pregnant patient diagnosed with COVID-19: A case report with clinical, radiological, and histopathological findings

COVID-19 and maternal mental health: Are we getting the balance right?

Coronavirus in pregnancy and delivery: rapid review and expert consensus

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