A case-control study of the association between DARPP-32 gene polymorphisms and alcohol dependence in Chinese Han subjects

Ma, Hongyu; Huang, Yinglin; Li, Xin; Lin, Ailu; Cong, Zhengtu; Zhu, Gang

doi:10.1016/j.psychres.2015.08.026

Cited by 2 publications

(4 citation statements)

References 7 publications

(9 reference statements)

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“…A 2 ml sample of venous blood was obtained from each participant for genotyping. Amplification of gene fragments containing the PPP1R1B SNPs rs12601930C/T, rs879606A/G, and rs3764352A/G by polymerase chain reaction and subsequent genotyping by restriction fragment length polymorphism analysis were carried out as described in our previous studies ( Li et al, 2011b ; Huang et al, 2013 ; Ma et al, 2015 , 2017 ).…”

Section: Methodsmentioning

confidence: 99%

“…To address this research gap, the present study investigated whether PPP1R1B variants were associated with performance on working memory, as assessed by WCST, in a healthy Chinese sample. Three PPPP1R1B SNPs, namely rs3764352A/G, rs879606A/G, and rs12601930C/T, were selected based on our previous studies of alcohol dependence ( Ma et al, 2015 ), personality traits ( Li et al, 2011b ), defense mechanisms ( Huang et al, 2013 ), and anxiety level ( Ma et al, 2017 ), and other teams’ related studies of emotional leaning ( Curcic-Blake et al, 2012 ) and cognitive performance ( Kunii et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

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Association of PPP1R1B polymorphisms with working memory in healthy Han Chinese adults

Qiu²,

Zhang³

et al. 2022

Front. Neurosci.

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AimsThe dopamine- and cAMP-regulated phosphoprotein (DARPP-32), which is encoded by the PPP1R1B gene, plays a converging regulatory role in the central nervous system by mediating the actions of dopamine, serotonin, and glutamate. Previous studies have demonstrated that variations in genes related to the dopamine system influence working memory. The present study thus investigated whether polymorphisms in PPP1R1B gene were associated with working memory.Materials and methodsA sample of 124 healthy Han Chinese were genotyped for three single nucleotide polymorphisms of PPP1R1B gene, namely rs12601930C/T, rs879606A/G, and rs3764352A/G, using polymerase chain reaction and restriction fragment length polymorphism analysis. Working memory performance was assessed using the Wisconsin Card Sorting Test (WCST).ResultsSignificant differences were observed in the Total Correct (TC), Total Errors (TE), and Conceptual Level Responses (CLR) scores of the WCST among the three rs12601930C/T genotypes (p = 0.044, 0.044, and 0.047, respectively); in TC, TE, Non-Perseverative Errors (NPE), and CLR scores between participants with the CC and (CT + TT) rs12601930C/T polymorphism genotypes (p = 0.032, 0.032, 0.019, and 0.029, respectively); in TC, TE, Perseverative Errors (PE), NPE, and CLR scores between participants with the (CT + CC) and TT rs12601930C/T polymorphism genotypes (p = 0.001, 0.001, 0.011, 0.004, and 0.001, respectively); and in NPE and CLR scores between participants with the GG and (AG + AA) genotypes of the rs3764352A/G polymorphism (p = 0.011 and 0.010). Furthermore, for males only, there were significant differences in TC, TE, PE, NPE, and CLR scores among the rs12601930C/T genotypes (p = 0.020, 0.020, 0.037, 0.029, and 0.014, respectively) and NPE and CLR scores among the rs3764352 genotypes (p = 0.045 and 0.042).ConclusionPPP1R1B gene polymorphisms rs12601930C/T and rs3764352A/G might be associated with working memory assessed by the WCST in healthy Chinese adults, especially among males.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of PPP1R1B polymorphisms with working memory in healthy Han Chinese adults

Qiu²,

Zhang³

et al. 2022

Front. Neurosci.

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show abstract

“…Later, studies on postmortem brains using the quantitative polymerase chain reaction, immunohistochemical staining, and immunoblotting demonstrated significantly changed expression of DARPP-32 in the dorsolateral prefrontal cortex (DLPFC) of patients with mental disorders such as schizophrenia and bipolar disorder [2,3]. At the same time, several gene association studies demonstrated that PPP1R1B polymorphisms or their haplotypes are associated with schizophrenia and substance dependence [4,5].…”

mentioning

confidence: 99%

“…Written consent was given by all participants and venous blood samples were taken. The polymorphism genotyping experiments were performed according to the methods described in our previous studies [4,8,9].…”

mentioning

confidence: 99%

A case-control study of the association between DARPP-32 gene polymorphisms and alcohol dependence in Chinese Han subjects

Cited by 2 publications

References 7 publications

Association of PPP1R1B polymorphisms with working memory in healthy Han Chinese adults

Association of PPP1R1B polymorphisms with working memory in healthy Han Chinese adults

Associations Between PPP1R1B Gene Polymorphisms and Anxiety Levels in the Chinese Population

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