Association of PPP1R1B polymorphisms with working memory in healthy Han Chinese adults

Abstract

AimsThe dopamine- and cAMP-regulated phosphoprotein (DARPP-32), which is encoded by the PPP1R1B gene, plays a converging regulatory role in the central nervous system by mediating the actions of dopamine, serotonin, and glutamate. Previous studies have demonstrated that variations in genes related to the dopamine system influence working memory. The present study thus investigated whether polymorphisms in PPP1R1B gene were associated with working memory.Materials and methodsA sample of 124 healthy Han Chinese were genotyped for three single nucleotide polymorphisms of PPP1R1B gene, namely rs12601930C/T, rs879606A/G, and rs3764352A/G, using polymerase chain reaction and restriction fragment length polymorphism analysis. Working memory performance was assessed using the Wisconsin Card Sorting Test (WCST).ResultsSignificant differences were observed in the Total Correct (TC), Total Errors (TE), and Conceptual Level Responses (CLR) scores of the WCST among the three rs12601930C/T genotypes (p = 0.044, 0.044, and 0.047, respectively); in TC, TE, Non-Perseverative Errors (NPE), and CLR scores between participants with the CC and (CT + TT) rs12601930C/T polymorphism genotypes (p = 0.032, 0.032, 0.019, and 0.029, respectively); in TC, TE, Perseverative Errors (PE), NPE, and CLR scores between participants with the (CT + CC) and TT rs12601930C/T polymorphism genotypes (p = 0.001, 0.001, 0.011, 0.004, and 0.001, respectively); and in NPE and CLR scores between participants with the GG and (AG + AA) genotypes of the rs3764352A/G polymorphism (p = 0.011 and 0.010). Furthermore, for males only, there were significant differences in TC, TE, PE, NPE, and CLR scores among the rs12601930C/T genotypes (p = 0.020, 0.020, 0.037, 0.029, and 0.014, respectively) and NPE and CLR scores among the rs3764352 genotypes (p = 0.045 and 0.042).ConclusionPPP1R1B gene polymorphisms rs12601930C/T and rs3764352A/G might be associated with working memory assessed by the WCST in healthy Chinese adults, especially among males.

Working memory gating in obesity is moderated by striatal dopaminergic gene variants

“…Consequently, we aim to examine this interactive effect and assess if it varies with BMI. In addition, the SNPs DARPP-32 and C957T have also been linked to working memory (Hotte et al, 2006 ;Ma et al, 2022 ;Smith, Swift-Scanlan & Boettiger, 2014 ;Xu et al, 2007 ;Klaus et al, 2019 ;Jacobsen et al, 2006 ). DARPP-32, or Dopamine and cAMP-regulated neuronal phosphoprotein, is a protein that potently modulates dopamine D1-dependent synaptic plasticity in the striatum (Ouimet et al, 1984 ;Calabresi et al, 2000 ;Lindskog et al, 2006 ;Girault & Nairn, 2021 ), and C957T is known to impact dopamine D2 mRNA translation (Duan et al, 2003 ) and postsynaptic D2 receptor availability in the striatum (Hivonen et al, 2005).…”

Working Memory Gating in Obesity is Moderated by Striatal Dopaminergic Gene Variants

“…Consequently, we aim to examine this interactive effect and assess if it varies with BMI. In addition, the SNPs DARPP-32 and C957T have also been linked to working memory (Hotte et al, 2006; Ma et al, 2022; Smith, Swift-Scanlan & Boettiger, 2014; Xu et al, 2007; Klaus et al, 2019; Jacobsen et al, 2006). DARPP-32, or Dopamine and cAMP-regulated neuronal phosphoprotein, is a protein that potently modulates dopamine D1-dependent synaptic plasticity in the striatum (Ouimet et al, 1984; Calabresi et al, 2000; Lindskog et al, 2006; Girault & Nairn, 2021), and C957T is known to impact dopamine D2 mRNA translation (Duan et al, 2003) and postsynaptic D2 receptor availability in the striatum (Hivonen et al, 2005).…”

“…Consequently, we aim to examine this interactive effect and assess if it varies with BMI. In addition, PPP1R1B and C957T gene polymorphisms have also been linked to working memory (Hotte et al, 2006;Ma et al, 2022;Smith, Swift-Scanlan & Boettiger, 2014;Xu et al, 2007;Klaus et al, 2019;Jacobsen et al, 2006). The PPP1R1B polymorphism (rs907094) codes for Dopamine and cAMP-regulated neuronal phosphoprotein (DARPP-32) -a protein that potently modulates dopamine D1dependent synaptic plasticity in the striatum (Ouimet et al, 1984;Calabresi et al, 2000;Lindskog et al, 2006;Girault & Nairn, 2021).…”