A case-control study of occupational magnetic field exposure and Alzheimer's disease: results from the California Alzheimer's Disease Diagnosis and Treatment Centers

Davanipour, Zoreh; Tseng, Chiu-Chen; Lee, Pey-Jiuan; Sobel, Eugene

doi:10.1186/1471-2377-7-13

Cited by 53 publications

(41 citation statements)

References 20 publications

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“…Several studies have suggested a possible association of ELF-MF with neoplastic malignancies in childhood, as well as with diseases affecting the nervous system [40,41]. In particular, ELF-MF has been associated with neurodegenerative diseases such as AD and ALS [12][13][14][15]. Epidemiological data have also highlighted the potential impact of ELF-MF exposure in brain and PD onset [15,16], although evidence is still poor and controversial.…”

Section: Discussionmentioning

confidence: 99%

“…Epidemiologic and toxicological studies have shown that environmental agents, mainly pesticides and heavy metals, represent primary classes of neurotoxic agents associated with PD [10,11]. More recently, several reports indicate that occupational exposure to electromagnetic fields might be associated with an increased risk of neurodegenerative diseases, mainly Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS) [12][13][14][15]; however, the epidemiological evidence supporting an univocal association between PD and exposure to electromagnetic fields remains poor and controversial [15,16]. In this context, ELF-MF (between 1 Hz up to 100 kHz, originating from power lines and household appliances, as well as welding machines, induction heaters, and transport systems) has been the factor generating most attention in neurodegenerative etiopathogenesis, as the interaction between ELF-MF and biological systems directly involves oxidative stress, in particular through the radical-based mechanism [17].…”

Section: Introductionmentioning

confidence: 99%

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Extremely Low Frequency Magnetic Field (ELF-MF) Exposure Sensitizes SH-SY5Y Cells to the Pro-Parkinson’s Disease Toxin MPP+

et al. 2015

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Parkinson's disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuron loss, with an etiopathogenesis involving both genetic and environmental factors. The occupational/residential exposure to the electromagnetic fields has been recently associated with an increased risk of neurodegenerative diseases; it has been thus proposed that the extremely low frequency magnetic field (ELF-MF) may contribute to neurodegenerative etiopathogenesis, as its interaction with biological systems directly impairs redox homeostasis in specific areas of the brain. The molecular mechanisms elicited by ELF-MF, and their potential involvement in PD onset, still remain unclear. To this end, we set up a generator of ELF-MF able to stably and homogeneously reproduce environmental prolonged exposure to ELF-MF (50 Hz, 1 mT). Results obtained indicate that ELF-MF exposure alters cell response of SH-SY5Y cells to MPP(+). We demonstrate that ELF-MF does not affect per se survival, shape, and morphology of both proliferating and differentiated SH-SY5Y cells but significantly impairs redox homeostasis and thiol content, triggering an increase in protein carbonylation. As a result, toxicity of MPP(+), even at low doses, is highly enhanced in ELF-MF-exposed cells due to a significant increase in ROS levels, potentiation of oxidative damage, and induction of a caspase-dependent apoptosis. Pre-incubation with the thiol antioxidants N-acetyl-L-cysteine and GSH ethyl-ester significantly reduces the extent of oxidative damage and protects cells from death induced by the combined treatment ELF-MF/MPP(+). Taken overall, our results demonstrate the redox-based molecular interaction between ELF-MF and PD neurotoxins in vitro, and open a new scenario for defining the synergy of environmental factors in PD onset.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Extremely Low Frequency Magnetic Field (ELF-MF) Exposure Sensitizes SH-SY5Y Cells to the Pro-Parkinson’s Disease Toxin MPP+

et al. 2015

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“…Several studies suggested that there is a possible association between ELF-MFs and malignancies in childhood and adulthood such as leukemia and nervous system tumors as well as cardiovascular and neurological disorders [Wertheimer and Leeper, 1979;IARC, 2002;Håkansson et al, 2003;Draper et al, 2005;Davanipour et al, 2007]. A number of in vivo and in vitro investigations have shown a possible co-promoter capacity of ELF-MFs on tumor growth as well as the potential effects elicited by ELF-MFs on various cellular functions [Crumpton and Collins, 2004;Simkó , 2004;Santini et al, 2005;Wolf et al, 2005;Berg and Berg, 2006;Frahm et al, 2006;Lisi et al, 2006;Palumbo et al, 2006;Gottwald et al, 2007].…”

mentioning

confidence: 97%

Molecular basis underlying the biological effects elicited by extremely low-frequency magnetic field (ELF-MF) on neuroblastoma cells

et al. 2011

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Extremely low-frequency magnetic fields (ELF-MFs) may affect human health because of the possible associations with leukemia but also with cancer, cardiovascular, and neurological disorders. In the present work, human SH-SY5Y neuroblastoma cells were exposed to a 50 Hz, 1 mT sinusoidal ELF-MF at three different times, that is, 5 days (T5), 10 days (T10), and 15 days (T15) and then the effects of ELF-MF on proteome expression and biological behavior were investigated. Through comparative analysis between treated and control samples, we analyzed the proteome changes induced by ELF-MF exposure. Nine new proteins resolved in sample after a 15-day treatment were involved in a cellular defense mechanism and/or in cellular organization and proliferation such as peroxiredoxin isoenzymes (2, 3, and 6), 3-mercaptopyruvate sulfurtransferase, actin cytoplasmatic 2, t-complex protein subunit beta, ropporin-1A, and profilin-2 and spindlin-1. Our results indicated that ELF-MFs exposure altered the proliferative status and other important cell biology-related parameters, such as cell growth pattern, and cytoskeletal organization. These findings support our hypothesis that ELF radiation could trigger a shift toward a more invasive phenotype.

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“…Epidemiological studies reported a link between the risks of various cancers, particularly childhood leukemia, and ELF-MF exposure [1]. Other studies suggested that exposure to magnetic fields (MFs) due to regular proximity to electrical power lines or occupational demands increased the risks of cardiovascular disease and Alzheimer's disease [2], [3]. In vitro studies have shown that ELF-MF could influence cell proliferation and cytoskeletal organization, and could induce DNA damage through the action of free radical species [4]～ [6].…”

Section: ⅰ Introductionmentioning

confidence: 99%

Effect of Extremely Low Frequency Magnetic Fields on Gene Expression in Human Mammary Epithelial MCF10A Cells

Hong¹,

Lee²,

Kim³

et al. 2012

Journal of electromagnetic engineering and science

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The effects of extremely low frequency magnetic fields (ELF-MFs) on physiological processes at the cellular level remain unclear despite a number of studies. To investigate the effects of ELF-MFs on gene expression, we exposed human mammary epithelial MCF10A cells to fields of 1 mT magnetic flux density at 60 Hz for 4 and 16 h and measured the transcriptional responses of 24,000 genes using Illumina microarrays. In three independent experiments, we found no statistically significant alteration of expression levels for any of the genes assayed using a cutoff value of 1.2-fold. To confirm this result, we selected six genes with trends suggesting possible expression level changes, although these trends were not statistically significant, and investigated their expression levels further using a semiquantitative reverse-transcription polymerase chain reaction. In three independent experiments, we did not find any alterations in the expression levels of these genes. From these results, we conclude that ELF-MFs do not affect gene expression profiles under our exposure conditions.

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A case-control study of occupational magnetic field exposure and Alzheimer's disease: results from the California Alzheimer's Disease Diagnosis and Treatment Centers

Cited by 53 publications

References 20 publications

Extremely Low Frequency Magnetic Field (ELF-MF) Exposure Sensitizes SH-SY5Y Cells to the Pro-Parkinson’s Disease Toxin MPP+

Extremely Low Frequency Magnetic Field (ELF-MF) Exposure Sensitizes SH-SY5Y Cells to the Pro-Parkinson’s Disease Toxin MPP+

Molecular basis underlying the biological effects elicited by extremely low-frequency magnetic field (ELF-MF) on neuroblastoma cells

Effect of Extremely Low Frequency Magnetic Fields on Gene Expression in Human Mammary Epithelial MCF10A Cells

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