A case-control study of environmental exposures for nonsyndromic cleft of the lip and/or palate in eastern Guangdong, China

Lin, Yu Hung; Shu, Shenyou; Tang, Shijie

doi:10.1016/j.ijporl.2014.01.002

Cited by 29 publications

(39 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This finding was similar to some former studies that showed that low parental education increased the risk of oral clefts in the offspring [38,39]. Good health depends on recognizing the risks of various lifestyles, and more education leads to a healthier lifestyle by means of creative work and a sense of controlling one’s own life [40].…”

Section: Discussionsupporting

confidence: 89%

Prevalence and Parental Risk Factors for Speech Disability Associated with Cleft Palate in Chinese Children—A National Survey

Yun

Wang

et al. 2016

IJERPH

View full text Add to dashboard Cite

Abstract:Although the prevalence of oral clefts in China is among the highest worldwide, little is known about the prevalence of speech disability associated with cleft palate in Chinese children. The data for this study were collected from the Second China National Sample Survey on Disability, and identification of speech disability associated with cleft palate was based on consensus manuals. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). A weighted number of 112,070 disabled children affected by cleft palate were identified, yielding a prevalence of 3.45 per 10,000 children (95% CI: 3.19-3.71). A history of speech disability in the mother (OR = 20.266, 95% CI 5.788-70.959, p < 0.0001), older paternal child-bearing age (OR = 1.061, 95% CI 1.017-1.108, p = 0.0065, per year increase in age), and lower parental education (maternal: OR = 3.424, 95% CI 1.082-10.837, p = 0.0363; paternal: OR = 2.923, 95% CI 1.245-6.866, p = 0.0138) were strongly associated with risk of speech disability associated with cleft palate in the offspring. Our results showed that maternal speech disability, older paternal child-bearing age, and lower levels of parental education were independent risk factors for speech disability associated with cleft palate for children in China. These findings may have important implications for health disparities and prevention.

show abstract

Section: Discussionsupporting

confidence: 89%

Prevalence and Parental Risk Factors for Speech Disability Associated with Cleft Palate in Chinese Children—A National Survey

Yun

Wang

et al. 2016

IJERPH

View full text Add to dashboard Cite

show abstract

“…To provide additional protection against this type of bias, we reanalyzed the data using conditional logistic regression after 1:1 case–control matching based on confounding characteristics and did not observe any significant differences in the estimates of risk, further strengthening our internal validity. Lower education and rural residence at birth have also been associated with clefts in other studies (Messer et al, ; Lin et al, ; Materna‐Kiryluk et al, ). Second, even though we found no appreciable differences in our estimates of risk for any cleft type versus cleft lip with or without cleft palate, our limited sample size did not permit us to examine risk estimates for isolated cleft palate.…”

Section: Discussionmentioning

confidence: 63%

“…Hypertensive disorders and antihypertensive medications use in early pregnancy have both been suggested to affect fetal development through teratogenic mechanisms (van Gelder et al, 2010). Other conditions, including diabetes (Spilson et al, 2001;Hrubec et al, 2009;Stott-Miller et al, 2010), seizures (Gadoth et al, 1987;Friis, 1989), and colds (Lin et al, 2014) have also been linked to oral clefts. Whether such conditions directly or indirectly affect palatogenesis by use of medications is possible (Hviid and Molgaard-Nielsen, 2011) but unclear to date.…”

Section: Seizures Nomentioning

confidence: 99%

Parental risk factors for oral clefts among Central Africans, Southeast Asians, and Central Americans

Figueiredo

Magee

et al. 2015

Birth Defects Research

View full text Add to dashboard Cite

BackgroundSeveral lifestyle and environmental exposures have been suspected as risk factors for oral clefts, although few have been convincingly demonstrated. Studies across global diverse populations could offer additional insight given varying types and levels of exposures.MethodsWe performed an international case–control study in the Democratic Republic of the Congo (133 cases, 301 controls), Vietnam (75 cases, 158 controls), the Philippines (102 cases, 152 controls), and Honduras (120 cases, 143 controls). Mothers were recruited from hospitals and their exposures were collected from interviewer‐administered questionnaires. We used logistic regression modeling to estimate odds ratios (OR) and 95% confidence intervals (CI).ResultsFamily history of clefts was strongly associated with increased risk (maternal: OR = 4.7; 95% CI, 3.0–7.2; paternal: OR = 10.5; 95% CI, 5.9–18.8; siblings: OR = 5.3; 95% CI, 1.4–19.9). Advanced maternal age (5 year OR = 1.2; 95% CI, 1.0–1.3), pregestational hypertension (OR = 2.6; 95% CI, 1.3–5.1), and gestational seizures (OR = 2.9; 95% CI, 1.1–7.4) were statistically significant risk factors. Lower maternal (secondary school OR = 1.6; 95% CI, 1.2–2.2; primary school OR = 2.4, 95% CI, 1.6–2.8) and paternal education (OR = 1.9; 95% CI, 1.4–2.5; and OR = 1.8; 95% CI, 1.1–2.9, respectively) and paternal tobacco smoking (OR = 1.5, 95% CI, 1.1–1.9) were associated with an increased risk. No other significant associations between maternal and paternal factors were found; some environmental factors including rural residency, indoor cooking with wood, chemicals and water source appeared to be associated with an increased risk in adjusted models.ConclusionOur study represents one of the first international studies investigating risk factors for clefts among multiethnic underserved populations. Our findings suggest a multifactorial etiology including both maternal and paternal factors. Birth Defects Research (Part A) 103:863–879, 2015. © 2015 The Authors Birth Defects Research Part A: Clinical and Molecular Teratology Published by Wiley Periodicals, Inc.

show abstract

“…Os grupos de medicamentos mais utilizados foram as vitaminas (79,4%), seguido dos antibióticos (9,1%), anticoncepcionais (2,5%) e anti-hipertensivos (2,5%). (3,(16)(17)(18)(19).…”

Section: Resultsunclassified

Perfil clínico-epidemiológico das fissuras orofaciais em um centro de referência do nordeste do Brasil

et al. 2019

View full text Add to dashboard Cite

RESUMOObjetivo Descrever o perfil clínico-epidemiológico dos portadores de fissuras orofaciais, atendidos em um Centro de Referência do Nordeste do Brasil. Métodos Estudo descritivo, baseado em dados secundários de prontuários médicos. Informações sociodemográficas do portador e da mãe, uso de medicamentos durante a gestação, aspectos clínicos e cirúrgicos relacionados às fissuras, histórico familiar da malformação e consanguinidade dos pais foram investigadas. Os dados foram analisados descritivamente, com o uso do programa estatístico SPSS (Statistical Package for te Social Sciences), no qual foram obtidas medidas de frequência, média e desvio padrão. Resultados 51,1% dos portadores de fissuras orofaciais eram do sexo feminino, 46,2% menores de um ano e 54,4% eram procedentes na zona urbana. A maioria das mães encontrava-se na faixa etária entre 16 a 25 anos durante o período gestacional e relatou uso de medicação em 59,2% dos casos. A fissura transforame incisivo foi a mais diagnosticada (34,4%). No momento de cadastro ao Centro de Reabilitação de Anomalias Craniofaciais, 90,5% dos indivíduos ainda não haviam realizado tratamento cirúrgico. História familiar de fissura foi observada em 29,8% dos casos estudados e em apenas 7,1% desses foi reportado consanguinidade entre os pais. Conclusão Os fatores socioeconômicos e genéticos podem exercer influência sobre o desenvolvimento de fissuras orofaciais, o que exige uma maior atenção governamental assim como novos estudos para melhor investigação. ABSTRACTObjective To describe the clinical-epidemiological profile of patients with orofacial fissures treated at a reference center from northeast Brazil. Materials and Methods Descriptive study, based on secondary data obtained from medical records. Sociodemographic information of patients and their mothers, use of medication during pregnancy, clinical and surgical aspects related to fissures, family history of malformation, and consanguinity among the parents were investigated. Data were analyzed descriptively using the SPSS (Statistical Package for Social Sciences) statistical program to obtain frequency, mean and standard deviation measures. Results 51.1% of the patients with orofacial fissures were female, 46.2% were under one year of age and 54.4% lived in urban areas. The majority of mothers were between the ages of 16 and 25 during the gestational period, and 59.2% reported the use of medication. Cleft lip and palate were the most prevalent types of fissures (34.4%). On admission to the Craniofacial Anomaly Rehabilitation Center, 90.5% of the individuals had not yet undergone surgical treatment. Family history of fissure was found in 29.8% of the cases studied, but inbreeding among parents was reported in only 7.1% of them. Conclusion Socioeconomic and genetic factors can influence the development of orofacial fissures; this requires greater governmental attention as well as new studies for better investigation. RESUMEN Perfil clínico-epidemiológico de las fisuras orofaciales en un centro de referencia en el nores...

show abstract

A case-control study of environmental exposures for nonsyndromic cleft of the lip and/or palate in eastern Guangdong, China

Cited by 29 publications

References 40 publications

Prevalence and Parental Risk Factors for Speech Disability Associated with Cleft Palate in Chinese Children—A National Survey

Prevalence and Parental Risk Factors for Speech Disability Associated with Cleft Palate in Chinese Children—A National Survey

Parental risk factors for oral clefts among Central Africans, Southeast Asians, and Central Americans

Perfil clínico-epidemiológico das fissuras orofaciais em um centro de referência do nordeste do Brasil

Contact Info

Product

Resources

About