Prevalence and Parental Risk Factors for Speech Disability Associated with Cleft Palate in Chinese Children—A National Survey

Yun, Chunfeng; Wang, Zhenjie; He, Ping; Guo, Chao; Chen, Gong; Zheng, Xiaoying

doi:10.3390/ijerph13111168

Cited by 6 publications

(6 citation statements)

References 39 publications

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“…Univariate analysis demonstrated that the MSD phenotype was associated with a lower educational level and a greater amount of manual labor, and a monolingual speaking background. These findings were partially in accordance with those of similar studies that focused mainly on the demographic characteristics and relevant evaluations in other types of SD [22–25]. Moreover, multivariate logistic regression analysis revealed a lower educational level as an independent risk factor for PD-associated MSD.…”

Section: Discussionsupporting

confidence: 91%

Attention/memory complaint is correlated with motor speech disorder in Parkinson’s disease

Liu

Gui

et al. 2019

BMC Neurol

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BackgroundThe mechanisms underlying the online modulation of motor speech in Parkinson’s disease (PD) have not been determined. Moreover, medical and rehabilitation interventions for PD-associated motor speech disorder (MSD) have a poor long-term prognosis.MethodsTo compare risk factors in PD patients with MSD to those without MSD (non-MSD) and determine predictive independent risk factors correlated with the MSD phenotype, we enrolled 314 PD patients, including 250 with and 64 without MSD. We compared demographic, characteristic data, as well as PD-associated evaluations between the MSD group and non-MSD group.ResultsUnivariate analysis showed that demographic characteristics, including occupation, educational level, monthly income and speaking background; clinical characteristics, including lesions in the frontal and temporal lobes, and concurrent dysphagia; and PD-associated evaluations, including the activity of daily living (ADL) score, non-motor symptoms scale (NMSS) domain 4 score (perceptual problem), and NMSS domain 5 score (attention/memory) were all significantly different between the MSD and non-MSD group (all P < 0.05). Multivariate logistic regression analysis showed that educational level, frontal lesions, and NMSS domain 5 score (attention/memory) were independent risk factors for PD-associated MSD (all P < 0.005).ConclusionsWe determined an association between MSD phenotype and cognitive impairment, reflected by low-level education and related clinical profiles. Moreover, attention and memory dysfunction may play key roles in the progression of MSD in PD patients. Further studies are required to detail the mechanism underlying abnormal speech motor modulation in PD patients. Early cognitive intervention may enhance rehabilitation management and motor speech function in patients with PD-associated MSD.

show abstract

Section: Discussionsupporting

confidence: 91%

Attention/memory complaint is correlated with motor speech disorder in Parkinson’s disease

Liu

Gui

et al. 2019

BMC Neurol

View full text Add to dashboard Cite

show abstract

“…Univariate analysis demonstrated that the MSD phenotype was associated with a lower educational level, a greater amount of manual labor, and a monolingual speaking background. These findings were partially in accordance with those of similar studies that focused mainly on the demographic characteristics and relevant evaluations in other types of SD [22][23][24][25]. Moreover, multivariate logistic regression analysis revealed a lower educational level as an independent risk factor for PD-associated MSD.…”

Section: Discussionsupporting

confidence: 91%

Cognitive Impairment is Correlated with Motor Speech Disorder in Parkinson’s Disease

Liu¹,

Gui²,

Hu³

et al. 2019

Preprint

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Background The mechanisms underlying the online modulation of motor speech in Parkinson’s disease (PD) have not been determined. Moreover, medical and rehabilitation interventions for PD-associated motor speech disorder (MSD) have a poor long-term prognosis. Methods To compare risk factors in PD patients with MSD to those without MSD (non-MSD) and determine predictive independent risk factors correlated with the MSD phenotype, we enrolled 314 PD patients, including 250 with and 64 without MSD. We compared demographic, characteristic data, as well as PD-associated evaluations between the MSD group and non-MSD group. Results Univariate analysis showed that demographic characteristics, including occupation, educational level, and monthly income; clinical characteristics, including lesions in the frontal and temporal lobes, and concurrent dysphagia; and PD-associated evaluations, including the activity of daily living (ADL) score, non-motor symptoms scale (NMSS) domain 4 score (perceptual problem), and NMSS domain 5 score (attention/memory) were all significantly different between the MSD and non-MSD group (all P < 0.05). Multivariate logistic regression analysis showed that educational level, frontal lesions, and NMSS domain 5 score (attention/memory) were independent risk factors for PD-associated MSD (all P < 0.005). Conclusions We determined an association between MSD phenotype and cognitive impairment, reflected by low-level education, weak language ability, and related clinical profiles. Moreover, attention and memory dysfunction may play key roles in the progression of MSD in PD patients. Further studies are required to detail the mechanism underlying abnormal speech motor modulation in PD patients. Early cognitive intervention may enhance rehabilitation management and motor speech function in patients with PD-associated MSD.

show abstract

“…Univariate analysis demonstrated that the MSD phenotype was associated with a lower educational level and a greater amount of manual labor, and a monolingual speaking background. These findings were partially in accordance with those of similar studies that focused mainly on the demographic characteristics and relevant evaluations in other types of SD [22][23][24][25]. Moreover, multivariate logistic regression analysis revealed a lower educational level as an independent risk factor for PD-associated MSD.…”

Section: Discussionsupporting

confidence: 91%

Attention/Memory Impairment is Correlated with Motor Speech Disorder in Parkinson’s Disease

Liu¹,

Gui

et al. 2019

Preprint

View full text Add to dashboard Cite

Background The mechanisms underlying the online modulation of motor speech in Parkinson’s disease (PD) have not been determined. Moreover, medical and rehabilitation interventions for PD-associated motor speech disorder (MSD) have a poor long-term prognosis. Methods To compare risk factors in PD patients with MSD to those without MSD (non-MSD) and determine predictive independent risk factors correlated with the MSD phenotype, we enrolled 314 PD patients, including 250 with and 64 without MSD. We compared demographic, characteristic data, as well as PD-associated evaluations between the MSD group and non-MSD group. Results Univariate analysis showed that demographic characteristics, including occupation, educational level, monthly income and speaking background; clinical characteristics, including lesions in the frontal and temporal lobes, and concurrent dysphagia; and PD-associated evaluations, including the activity of daily living (ADL) score, non-motor symptoms scale (NMSS) domain 4 score (perceptual problem), and NMSS domain 5 score (attention/memory) were all significantly different between the MSD and non-MSD group (all P < 0.05). Multivariate logistic regression analysis showed that educational level, frontal lesions, and NMSS domain 5 score (attention/memory) were independent risk factors for PD-associated MSD (all P < 0.005). Conclusions We determined an association between MSD phenotype and cognitive impairment, reflected by low-level education and related clinical profiles. Moreover, attention and memory dysfunction may play key roles in the progression of MSD in PD patients. Further studies are required to detail the mechanism underlying abnormal speech motor modulation in PD patients. Early cognitive intervention may enhance rehabilitation management and motor speech function in patients with PD-associated MSD.

show abstract

Prevalence and Parental Risk Factors for Speech Disability Associated with Cleft Palate in Chinese Children—A National Survey

Cited by 6 publications

References 39 publications

Attention/memory complaint is correlated with motor speech disorder in Parkinson’s disease

Attention/memory complaint is correlated with motor speech disorder in Parkinson’s disease

Cognitive Impairment is Correlated with Motor Speech Disorder in Parkinson’s Disease

Attention/Memory Impairment is Correlated with Motor Speech Disorder in Parkinson’s Disease

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