A carrier free photodynamic oxidizer for enhanced tumor therapy by redox homeostasis disruption

Ni, Yang; Zheng, Rongrong; Chen, Ziying; Wang, Rui‐Xin; Zhao, Lin‐Ping; Chen, Xia-Yun; Chen, Lei; Xu, Lin; Li, Shiying; Chen, A‐Li

doi:10.1039/d1bm01876k

Cited by 11 publications

(10 citation statements)

References 27 publications

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“…The interaction of these two opposing systems raises the homeostatic ROS setpoint, which gives cancer cells an edge in terms of proliferation. [82] In that context, redox modulation represents a reasonable strategy for the prevention and treatment of cancer. On the one hand, neutralizing moderate ROS that is crucial for carcinogenesis would suppress a tumor by restricting cellular signaling transduction, physiological activity and the synthesis of biomolecules.…”

Section: Discussionmentioning

confidence: 99%

Nanomedicine-based modulation of redox status for cancer therapy

Park

Nice

et al. 2023

Aust. J. Chem.

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Cancer has always been a major disease with an unfavorable impact on human health worldwide. Redox biology has a close and complicated relationship to the initiation and progression of cancer. Continuous work is being conducted to develop novel approaches for cancer prevention and therapy by modulating redox homeostasis, but problems in drug targeting, drug resistance, adverse effects and recurrence are persistent challenges. Nanotechnology is emerging as a powerful tool to achieve specific targeting, non-invasive therapeutics, high therapeutic efficiency and improved drug sensitivity for cancers by exploiting the features of their microenvironment, especially the redox properties. In addition, nanoplatform-mediated delivery of anticancer drugs or exogenous antioxidants/oxidants affords a promising prospect for cancer therapy. In this review, we will summarize recent advances in redox species-responsive nanoplatforms for tumor treatment. Current nanocarrier mediated strategies that manage redox status for cancer treatment will also be discussed.

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Section: Discussionmentioning

confidence: 99%

Nanomedicine-based modulation of redox status for cancer therapy

Park

Nice

et al. 2023

Aust. J. Chem.

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“…Additionally, Ppa, a compound formed by the natural product chlorophyl a with an aromatic azalenene structure, has strong absorption spectra at 600—700 nm. 410 Zheng et al. 65 developed a self‐stabilized supramolecular assembly (SSA) based on a PEG‐dendritic peptide‐Ppa (PDPP).…”

Section: Application Strategies Of Multifunctional Nanoparticlesmentioning

confidence: 99%

“…Their results illustrated that QD‐Ce6 complexes generated 10‐fold and 19‐fold higher singlet oxygen than Ce6 and QDs in PBS, respectively. Additionally, Ppa, a compound formed by the natural product chlorophyl a with an aromatic azalenene structure, has strong absorption spectra at 600—700 nm 410 . Zheng et al 65 .…”

Section: Application Strategies Of Multifunctional Nanoparticlesmentioning

confidence: 99%

Multifunctional nanoparticle for cancer therapy

Wang

Zhang

Duan

et al. 2023

MedComm

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Cancer is a complex disease associated with a combination of abnormal physiological process and exhibiting dysfunctions in multiple systems. To provide effective treatment and diagnosis for cancer, current treatment strategies simultaneously focus on various tumor targets. Based on the rapid development of nanotechnology, nanocarriers have been shown to exhibit excellent potential for cancer therapy. Compared with nanoparticles with single functions, multifunctional nanoparticles are believed to be more aggressive and potent in the context of tumor targeting. However, the development of multifunctional nanoparticles is not simply an upgraded version of the original function, but involves a sophisticated system with a proper backbone, optimized modification sites, simple preparation method, and efficient function integration. Despite this, many well‐designed multifunctional nanoparticles with promising therapeutic potential have emerged recently. Here, to give a detailed understanding and analyzation of the currently developed multifunctional nanoparticles, their platform structures with organic or inorganic backbones were systemically generalized. We emphasized on the functionalization and modification strategies, which provide additional functions to the nanoparticle. We also discussed the application combination strategies that were involved in the development of nanoformulations with functional crosstalk. This review thus provides an overview of the construction strategies and application advances of multifunctional nanoparticles.

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“…Recently, since the production of excess reactive oxygen species (ROS) could cause the intracellular redox balance to bias toward an oxidative stress state, resulting in cell death, the use of cytotoxic ROS to kill tumor cells in cancer treatment has attracted lots of attention. 1–5 As one of the ROS-based strategies, chemodynamic therapy (CDT) can transform H 2 O 2 into ·OH by means of a Fenton or Fenton-like reaction between the nanocatalyst and H 2 O 2 without any external energy. 6–12 Since H 2 O 2 is excessively expressed in tumor cells, 13–19 CDT can not only play an effective role in tumor therapy, but also reduce the damage to normal tissue by ROS.…”

Section: Introductionmentioning

confidence: 99%