A cardiac troponin I photoelectrochemical immunosensor: nitrogen-doped carbon quantum dots–bismuth oxyiodide–flower-like SnO2

Fan, Dawei; Liu, Xin; Shao, Xinrong; Zhang, Yong; Wei, Qin; Ju, Huangxian

doi:10.1007/s00604-020-04302-x

Cited by 18 publications

(7 citation statements)

References 53 publications

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“…The LOD obtained was significantly lower than the maximum limits allowed for a clinical diagnosis of myocardial infarction at approximately 0.1 ng mL −1 [ 29 ]. In combination with the linear range of response, this result was compared to further reported PEC immunosensors for cTnI ( Table 1 : references [ 3 , 15 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ]). As can be seen, the anti-cTnI/Bi 2 S 3 /BiVO 4 /FTO immunosensor presents some interesting features for the determination of this biomarker in comparison to previously reported PEC sensors.…”

Section: Resultsmentioning

confidence: 99%

Photoelectrochemical Determination of Cardiac Troponin I as a Biomarker of Myocardial Infarction Using a Bi2S3 Film Electrodeposited on a BiVO4-Coated Fluorine-Doped Tin Oxide Electrode

et al. 2023

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A sensitive and selective label-free photoelectrochemical (PEC) immunosensor was designed for the detection of cardiac troponin I (cTnI). The platform was based on a fluorine-doped, tin oxide (FTO)-coated glass photoelectrode modified with bismuth vanadate (BiVO4) and sensitized by an electrodeposited bismuth sulfide (Bi2S3) film. The PEC response of the Bi2S3/BiVO4/FTO platform for the ascorbic acid (AA) donor molecule was approximately 1.6-fold higher than the response observed in the absence of Bi2S3. The cTnI antibodies (anti-cTnI) were immobilized on the Bi2S3/BiVO4/FTO platform surface to produce the anti-cTnI/Bi2S3/BiVO4/FTO immunosensor, which was incubated in cTnI solution to inhibit the AA photocurrent. The photocurrent obtained by the proposed immunosensor presented a linear relationship with the logarithm of the cTnI concentration, ranging from 1 pg mL−1 to 1000 ng mL−1. The immunosensor was successfully employed in artificial blood plasma samples for the detection of cTnI, with recovery values ranging from 98.0% to 98.5%.

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Section: Resultsmentioning

confidence: 99%

Photoelectrochemical Determination of Cardiac Troponin I as a Biomarker of Myocardial Infarction Using a Bi2S3 Film Electrodeposited on a BiVO4-Coated Fluorine-Doped Tin Oxide Electrode

et al. 2023

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“…Further, the decreasing photocurrent can be attributed to the numerous radicals created via excessive H 2 O 2 . As a result, the charge carriers have difficulty crossing the high potential barrier and transport in the grains, ultimately resulting in the decrease of photocurrent. , Thus, the optimal concentration of H 2 O 2 is 30.0 mM, which enables the sensor to obtain the optimum photocurrent. Moreover, the incubation time of anti-cTnI and BSA is also a vital factor in promoting sufficient and stable antigen binding.…”

Section: Resultsmentioning

confidence: 99%

S-Scheme Porphyrin Covalent Organic Framework Heterojunction for Boosted Photoelectrochemical Immunoassays in Myocardial Infarction Diagnosis

Huang

Zhang

et al. 2023

ACS Sens.

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Cardiac troponin I (cTnI) is an extremely sensitive biomarker for early indication of acute myocardial infarction (AMI). However, it still remains a tough challenge for many newly developed cTnI biosensors to achieve superior sensing performance including high sensitivity, rapid detection, and resistance to interference in clinical serum samples. Herein, a novel photocathodic immunosensor toward cTnI sensing has been successfully developed by designing a unique S-scheme heterojunction based on the porphyrin-based covalent organic frameworks (p-COFs) and p-type silicon nanowire arrays (p-SiNWs). In the novel heterojunction, the p-SiNWs are employed as the photocathode platform to acquire a strong photocurrent response. The in situ-grown p-COFs can accelerate the spatial migration rate of charge carriers by forming proper band alignment with the p-SiNWs. The crystalline π-conjugated network of p-COFs with abundant amino groups also promotes the electron transfer and anti-cTnI immobilizing process. The developed photocathodic immunosensor demonstrates a broad detection range of 5 pg/mL–10 ng/mL and a low limit of detection (LOD) of 1.36 pg/mL in clinical serum samples. Besides, the PEC sensor owns several advantages including good stability and superior anti-interference ability. By comparing our results with that of the commercial ELISA method, the relative deviations range from 0.06 to 0.18% (n = 3), and the recovery rates range from 95.4 to 109.5%. This work displays a novel strategy to design efficient and stable PEC sensing platforms for cTnI detection in real-life serums and provides guidance in future clinical diagnosis.

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“…There are also composite materials by using other materials as the substrate including Au–Pd/MnO 2 , FeOOH/Bi 2 S 3 /Au, and so on. − …”

Section: States Of Art On Clinically Oriented Biosensors For Troponin...mentioning

confidence: 99%

Progress, Opportunities, and Challenges of Troponin Analysis in the Early Diagnosis of Cardiovascular Diseases

Zhang

et al. 2021

Anal. Chem.

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A cardiac troponin I photoelectrochemical immunosensor: nitrogen-doped carbon quantum dots–bismuth oxyiodide–flower-like SnO2

Cited by 18 publications

References 53 publications

Photoelectrochemical Determination of Cardiac Troponin I as a Biomarker of Myocardial Infarction Using a Bi2S3 Film Electrodeposited on a BiVO4-Coated Fluorine-Doped Tin Oxide Electrode

Photoelectrochemical Determination of Cardiac Troponin I as a Biomarker of Myocardial Infarction Using a Bi2S3 Film Electrodeposited on a BiVO4-Coated Fluorine-Doped Tin Oxide Electrode

S-Scheme Porphyrin Covalent Organic Framework Heterojunction for Boosted Photoelectrochemical Immunoassays in Myocardial Infarction Diagnosis

Progress, Opportunities, and Challenges of Troponin Analysis in the Early Diagnosis of Cardiovascular Diseases

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