A Canine Parvovirus Mutant Is Spreading in Italy

Canine Parvovirus: Current Perspective

“…The prevalence of CPV-2b has been reported by various authors in several countries namely Brazil [71], USA [69], Japan [32], Switzerland [95] and South Africa [87]. Contrastingly, CPV-2a was found to be the prevalent antigenic type in France, Taiwan and Italy [13,48]. However both CPV-2a and CPV-2b have been found to be distributed in equal proportion in Spain [18] and U.K. [28].…”

Isolation and Typing of Canine Parvovirus in CRFK Cell Line in Puducherry, South India

“…Glu, which occurs in a residue of the capsid protein that is considered important for the antigenic properties of CPV-2. This variant (CPV-2/ Glu-426 mutant), currently named as CPV-2c, is distributed in Italy [5], Spain [6], United Kingdom [7], and very recently in Portugal [8]. The disease is reported to be prevalent among canine populations in Puducherry [9].…”

Genetic Analysis of VP2 Gene of Canine Parvovirus Isolates in Korea

“…Mutations affecting important residues of the capsid protein of CPV, such as residues 300 and 426, have been recognized recently, suggesting that CPV is still in the process of evolution [3,13,15,17,26]. Ikeda et al reported that the CPV-2c(a) and CPV-2c(b)-type viruses emerged from CPV-2a-and CPV-2b-type viruses in domestic and leopard cats in Vietnam [13].…”

“…In the 1980s, two antigenic variants of CPV-2, distinguishable using monoclonal antibodies (MoAbs), emerged almost simultaneously and were termed CPV-2a and CPV-2b [10,19]. Currently, CPV-2a is major field strain in India, Italy and Germany, while CPV-2b is common in USA, Taiwan, and Japan [2,5,7,9,15,25].…”