A candidate gene approach to study nematode resistance traits in naturally infected sheep

Wilkie, Hazel; Riggio, Valentina; Matika, Oswald; Nicol, Louise; Watt, Kathryn; Sinclair, Rona; Sparks, Alexandra M.; Nussey, Daniel H.; Pemberton, Josephine M.; Houston, Ross D.

doi:10.1016/j.vetpar.2017.06.010

Cited by 11 publications

(8 citation statements)

References 18 publications

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“…Causal mutant alleles at the DRB1 and DQB2 loci were identified that were associated with this trait. Single nucleotide polymorphisms (SNPs) in three other candidate genes for nematode resistance and body weight were examined in populations of domestic Scottish Blackface and free-living Soay ewe lambs, and a nominally significant association between an IL23R SNP and body weight was found [58].…”

Section: Genetic Diversity Qtl and Candidate Gene Characterizationmentioning

confidence: 99%

British Sheep Breeds as a Part of World Sheep Gene Pool Landscape: Looking into Genomic Applications

Romanov

Zinovieva

Griffin

2021

Animals

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Sheep farming has been an important sector of the UK’s economy and rural life for many centuries. It is the favored source of wool, meat and milk products. In the era of exponential progress in genomic technologies, we can now address the questions of what is special about UK sheep breed genotypes and how they differ genetically form one another and from other countries. We can reflect how their natural history has been determined at the level of their genetic code and what traces have been left in their genomes because of selection for phenotypic traits. These include adaptability to certain environmental conditions and management, as well as resistance to disease. Application of these advancements in genetics and genomics to study sheep breeds of British domestic selection has begun and will continue in order to facilitate conservation solutions and production improvement.

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Section: Genetic Diversity Qtl and Candidate Gene Characterizationmentioning

confidence: 99%

British Sheep Breeds as a Part of World Sheep Gene Pool Landscape: Looking into Genomic Applications

Romanov

Zinovieva

Griffin

2021

Animals

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“…The extensive work on phenotypes and associated parasitism rates has allowed the Soay sheep system to be explored with candidate gene approaches (Brown et al 2013) to identify genes related to parasite resistance (Wilkie et al 2017). Soay sheep have also been studied to determine whether parasitism impacts diet selection for application to farmed breeds (Jones et al 2006).…”

Section: <Comp: Please Insert Figure 2 Here>mentioning

confidence: 99%

What Have Long-Term Field Studies Taught Us About Population Dynamics?

Reinke

Miller

Janzen

2019

Annu. Rev. Ecol. Evol. Syst.

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Long-term studies have been crucial to the advancement of population biology, especially our understanding of population dynamics. We argue that this progress arises from three key characteristics of long-term research. First, long-term data are necessary to observe the heterogeneity that drives most population processes. Second, long-term studies often inherently lead to novel insights. Finally, long-term field studies can serve as model systems for population biology, allowing for theory and methods to be tested under wellcharacterized conditions. We illustrate these ideas in three long-term field systems that have made outsized contributions to our understanding of population ecology, evolution, and conservation biology. We then highlight three emerging areas to which long-term field studies are well positioned to contribute in the future: ecological forecasting, genomics, and macrosystems ecology. Overcoming the obstacles associated with maintaining long-term studies requires continued emphasis on recognizing the benefits of such studies to ensure that long-term research continues to have a substantial impact on elucidating population biology. AbstractLong-term studies have been crucial to the advancement of population biology, especially our understanding of population dynamics. We argue that this progress arises from three key characteristics of long-term research. First, long-term data are necessary to observe the heterogeneity that drives most population processes. Second, long-term studies often inherently lead to novel insights. Finally, long-term field studies can serve as model systems for population biology, allowing for theory and methods to be tested under well-characterized conditions. We illustrate these ideas in three long-term field systems that have made outsized contributions to our understanding of population ecology, evolution, and conservation biology. We then highlight three emerging areas to which long-term field studies are well positioned to contribute in the future: ecological forecasting, genomics, and macrosystems ecology. Overcoming the obstacles associated with maintaining long-term studies requires continued emphasis on recognizing the benefits of such studies to ensure that long-term research continues to have a substantial impact on elucidating population biology.

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“…Como alternativa al uso de medicamentos, para el control de los PGI se ha sugerido la selección de animales genéticamente resistentes (6,13,14). Este proceso de cría selectiva para la resistencia al PGI utiliza el recuento de huevos fecales (FEC), ensayos de anticuerpos, volumen de células empaquetadas y puntuación de anemia por el método FAMACHA ® , como indicadores de resistencia (7,15).…”

Section: Introductionunclassified

“…En razón a lo anterior, los estudios de asociación de genoma completo en diversas razas ovinas han asociado determinados polimorfismos en los genes GLI1 y IL20RA como candidatos a la resistencia contra PGI (13,14,15,19). Dichos polimorfismos no han sido caracterizados en la raza OPC.…”

Section: Introductionunclassified

Genetic variation in two candidate genes against gastrointestinal parasites in Colombian Hair Sheep

Hernández-Herrera

Lenis-Valencia²,

Montes-Vergara³

2024

Rev MVZ Córdoba

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Objetivo. Caracterizar dos polimorfismos genéticos tipo SNP en los genes GLI1 (rs411868094) y IL20RA (rs419463995) candidatos a la resistencia contra parásitos gastrointestinales en dos biotipos de ovinos de pelo colombiano. Materiales y métodos. Del banco de ADN del laboratorio de Genética Animal de la Universidad de Sucre, se analizaron 167 muestras de ovino de pelo colombiano (OPC), pertenecientes a los biotipos Etíope (n=94) y Sudán (n=73), mediante PCR y secuenciamiento bidireccional dos SNPs en los genes GLI1 (T>G) y IL20RA (G>A). Se calcularon las frecuencias alélicas y genotípicas, la heterocigocidad observada (Ho) y esperada (He), el índice F y las desviaciones del equilibrio de Hardy-Weinberg (EHW) con el programa GENALEX versión 6.5. Resultados. Para el gen GLI1 para todo el OPC las frecuencias genotípicas promedio fueron 0.155±0.07, 0.370±0.07 y 0.475±0.07 para GG, GT y TT, respectivamente. En el biotipo Etíope, se encontraron las frecuencias más altas del genotipo GG. Para el gen IL20RA en todo el OPC, los genotipos AA y AG tuvieron similar frecuencia (0.465±0.03) y el genotipo GG mostró la frecuencia más baja (0.110±0.01). Conclusiones. Las variantes genéticas analizadas fueron polimórficas. Según los reportes de literatura, los alelos de interés por su mejor desempeño contra los parásitos gastrointestinales, tuvieron baja frecuencia en el gen GLI1, pero alta frecuencia en el IL20RA.

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A candidate gene approach to study nematode resistance traits in naturally infected sheep

Abstract: HighlightsSNPs within genes associated with the development of nematode resistance were sequenced.The SNPs were segregating in two unrelated, domestic and feral, sheep breeds.More samples are required to determine significant associations between SNPs and traits.

Cited by 11 publications

References 18 publications

British Sheep Breeds as a Part of World Sheep Gene Pool Landscape: Looking into Genomic Applications

British Sheep Breeds as a Part of World Sheep Gene Pool Landscape: Looking into Genomic Applications

What Have Long-Term Field Studies Taught Us About Population Dynamics?

Genetic variation in two candidate genes against gastrointestinal parasites in Colombian Hair Sheep

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