Introduction: Schizophrenia is a chronic mental disorder prevalent across the globe. Because of its chronic course, most of the individuals with schizophrenia require lifelong treatment which may pose financial, physical, and mental burden over the primary caregivers. So, while taking care of the individuals with schizophrenia over a prolonged period, caregivers themselves can suffer from the burden in the form of depression, anxiety, and stress. Objective: To study the relationship between caregiver burden in the form of depression, anxiety and stress, and the resilience among the primary caregivers of individuals with schizophrenia. Methodology: Present crosssectional study was carried out by the department of Psychiatry of a tertiary care rural teaching hospital from Maharashtra, India. Data were collected from 80 primary caregivers by using standard questionnaires like Depression, Anxiety and Stress -21 item (DASS-21) scale to measure the caregiver burden and Brief Resilience Scale (BRS) to measure the levels of resilience. Results:Prevalence of depression, anxiety, and stress were 55%, 35%, and 48.7% respectively. Significant negative correlation was observed between resilience levels and depression (r= -0.23), anxiety (r= -0.35), and stress (r= -0.24), suggesting that the probability of the caregiver burden increases with decline in the level of resilience. Conclusion: Based on the findings, we recommend that regular individual as well as group sessions should be conducted for the primary caregivers to strengthen their resilience so that they can not only