A C-glucoside benzoic acid derivative from the leaves of Peltophorum dubium

Bahia, Marcus Vinicius; David, Jorge M.; Rezende, Larissa C. de; Guédès, Michel; David, Juceni P.

doi:10.1016/j.phytol.2010.07.002

Cited by 5 publications

(4 citation statements)

References 15 publications

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“…Antioxidant activity has been reported for the acetone extract of the root and bark of P. africanum [ 15 ]. Other Peltophorum species with reported antioxidant activity include: P. pterorcarpum, P. ferrugineum , and P. dubium [ 36 - 38 ].…”

Section: Resultsmentioning

confidence: 99%

In vitro determination of the anti-aging potential of four southern African medicinal plants

Ndlovu

Fouché

Tselanyane

et al. 2013

BMC Complement Altern Med

102

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BackgroundAging is an inevitable process for all living organisms. During this process reactive oxygen species generation is increased which leads to the activation of hyaluronidase, collagenase and elastase, which can further contribute to skin aging. Four southern African medicinal plants; Clerodendrum glabrum, Schotia brachypetala, Psychotria capensis and Peltophorum africanum, were investigated to assess their anti-aging properties.MethodsAnti-elastase, anti-collagenase and anti-hyaluronidase activities of twenty-eight samples, consisting of methanol and ethyl acetate extracts of the four plants, were determined using spectrophotometric methods. Radical scavenging activity was determined by the ability of the plant extracts to scavenge the ABTS•+ radical.ResultsThe majority of the samples in the anti-elastase assay and nine in the anti-collagenase assay showed more than 80% inhibition. The ethyl acetate extract of S. brachypetala bark and leaves of P. capensis inhibited elastase activity by more than 90%. The methanol extract of S. brachypetala bark contained the highest anti-hyaluronidase activity (75.13 ± 7.49%) whilst the ethyl acetate extract of P. africanum bark exhibited the highest antioxidant activity (IC50: 1.99 ± 0.23 μg/ml).ConclusionThe free radical scavenging activity and enzyme inhibitory activity of the plant extracts investigated suggests that they can help restore skin elasticity and thereby slow the wrinkling process. P. africanum was the plant with the most promising activity and will be subjected to further testing and isolation of the active compound/s.

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Section: Resultsmentioning

confidence: 99%

In vitro determination of the anti-aging potential of four southern African medicinal plants

Ndlovu

Fouché

Tselanyane

et al. 2013

BMC Complement Altern Med

102

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“…(Fabaceae) showed inhibitory activity against Staphylococcus aureus [ 11 ]. The extracts of different parts of this plant were purified, and bergenin was isolated in high yields, especially from the roots and barks of P. dubium [ 12 , 13 ]. This plant is a large tree from the Fabaceae family, commonly known as “canafístula” or “angico-vermelho”, which grows in some South American countries, particularly in Brazil’s central and southern regions.…”

Section: Introductionmentioning

confidence: 99%

“…Its wood is used in civil construction, furniture, and naval industries [ 14 ]. Besides bergenin and derivatives, species of this genus is known to biosynthesize flavonoids, phenoxychromenes, terrestribisamide, and lignans [ 13 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Microwave extraction and molecular imprinted polymer isolation of bergenin applied to the dendrochronological chemical study of Peltophorum dubium

Silva-Neto,

Felix,

de Oliveira Aguiar

et al. 2024

BMC Chemistry

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This study describes methodologies for extracting and isolating bergenin, a C-glucoside of 4-O-methylgallic acid found in some plants and it presents various in vitro and in vivo biological activities. Bergenin was previously obtained from the Pelthophorum dubim (Fabaceae) roots with a good yield. Conventional chromatographic procedures of the CHCl3 soluble fraction of the MeOH extract gave 3.62% of this glucoside. An HPLC/DAD method was also developed and validated for bergenin and its precursor, gallic acid quantifications. Microwave extractions with different solvents were tested to optimize the extraction of bergenin, varying the temperature and time. MAE (Microwave Assisted Extraction) was more efficient than conventional extraction procedures, giving a higher yield of bergenin per root mass (0.45% vs. 0.0839%). Molecularly imprinted polymer (MIP) and non-imprinted polymer (NIP) based on bergenin as the template molecule, methacrylic acid, and ethylene glycol dimethacrylate were synthesized and characterized by FTIR and SEM (Scanning Electron Microscopy). Bergenin adsorption experiments using MIP and NIP followed by molecular imprinted solid phase extraction (MISPE) showed that MIP had a higher selectivity for bergenin than NIP. A dendrochronological study using the proposed method for detection and quantification of gallic acid and bergenin in five P. dubium growth rings of a 31-year-old heartwood and in the phelloderm and barks indicated that bergenin was more abundant in the 11–14th growth rings of the heartwood and decreased from the heartwood to the barks.

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“…On the other hand, the seeds have shown insecticidal activity against Anagasta kuehniella (Lepidoptera: Pyralidae) [16], and a trypsin inhibitor that induces cell death in human leukemia [17] was also isolated. Moreover, Reference [18] managed to isolate C-glucoside benzoic acid derivative, a new compound, from the leaves with antioxidant activity. It should be noted that other species of the genus Peltophorum, such as P. Pterocarpus, were studied for their antibacterial and antifungal activity [19,20] and also as an antioxidant [21,22], while from the P. Vogelianum species, several compounds were isolated, from which peltophorumyl β-D glucupyranoside with antibacterial properties stands out [23].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Antifungal Activity of Peltophorum dubium (Spreng.) Taub. extracts against Aspergillus flavus

Ciaccio

Catalano

López

et al. 2020

Plants

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Aspergillus flavus is a filamentous, saprophytic fungus, whose colonization occurs mainly in cereal grains and oilseeds once harvested. Under certain conditions, it could produce mycotoxins called aflatoxins, known as powerful human liver carcinogens. The aim of the present study was to describe the antifungal activity of extracts of Peltophorum dubium, a species from northern Argentina (Oriental Chaco), against A. flavus. The antifungal activities of different collection sites are reported. The extracts exhibited a minimum inhibitory concentration of 125 µg/mL, and the differences between the treatments and the inoculum control were 11 mm of P. dubium A and 10 mm of P. dubium F in colony growth. Moreover, hyphae treated with the extracts stained blue with Evans blue showed alterations in the membrane and/or cell wall, allowing the dye income. Bio-guided fractionation, High Performance Liquid Chromatography diode array ultraviolet/visible (HPLC UV/VIS DAD), and Ultra-High Performance Liquid Chromatography Electrospray Ionization Mass Spectrometry (UPLC ESI-MS) analyses were conducted to characterize the extracts and their active fractions. The HPLC UV/VIS DAD analysis allowed the determination of the presence of flavonoids (flavonols and flavones), coumarins, terpenes, and steroids. UPLC ESI/MS analysis of active fractions revealed the presence of Kaempferol, Apigenin, Naringenin, Chrysin and Daidzein.

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A C-glucoside benzoic acid derivative from the leaves of Peltophorum dubium

Cited by 5 publications

References 15 publications

In vitro determination of the anti-aging potential of four southern African medicinal plants

In vitro determination of the anti-aging potential of four southern African medicinal plants

Microwave extraction and molecular imprinted polymer isolation of bergenin applied to the dendrochronological chemical study of Peltophorum dubium

In Vitro Antifungal Activity of Peltophorum dubium (Spreng.) Taub. extracts against Aspergillus flavus

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