A bullous eruption in an elderly woman. Vancomycin-associated linear IgA dermatosis (LAD)

Ss, Richards; Hall, Sarah; Yokel, Benjamin K.; Se, Whitmore

doi:10.1001/archderm.131.12.1447b

Cited by 27 publications

(7 citation statements)

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“…A previous review of 47 VILABD cases revealed that the male-to-female ratio was 1Á6 : 1 and the age of onset ranged from 32 to 92 years (mean 68 years). It was also reported that the skin lesions appeared 1 [14][15][16] to 21 days (mean 9Á8 days) after VCM administration, and that the symptoms were alleviated within 60 days (mean 20Á5 days) after VCM discontinuation. 1, In the present case, circulating IgA antilaminin-332 antibodies were detected 2 days after VCM administration.…”

Section: Discussionmentioning

confidence: 93%

A case of vancomycin-associated linear IgA bullous dermatosis and IgA antibodies to the α3 subunit of laminin-332

et al. 2014

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Linear IgA bullous dermatosis (LABD) is a rare autoimmune bullous disease, which is defined by the histopathological finding of subepidermal vesicles with neutrophilic infiltration and linear IgA deposits in the basement membrane zone, revealed by immunofluorescence study. We present a case of LABD in which vancomycin (VCM) administration triggered LABD, and immunoblot analysis showed IgA antibodies reactive to the 145- and 165-kDa α3 subunits of laminin-332. This is the first report of VCM-associated LABD in which the target antigen was laminin-332. In the present case, we were compelled to continue administration of VCM along with systemic steroids, which eventually led to the attenuation of the symptoms, normalization of the serum IgA level, and negative results on both indirect immunofluorescence of 1 mol L(-1) NaCl-split skin and immunoblot analysis.

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Section: Discussionmentioning

confidence: 93%

A case of vancomycin-associated linear IgA bullous dermatosis and IgA antibodies to the α3 subunit of laminin-332

et al. 2014

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“…IIF can be either negative or detect low levels of IgA anti-BMZ antibodies. The sera of LAD patients have demonstrated binding to proteins of various molecular weights including 97, 120, 180, and 285 kDa proteins (11,(89)(90)(91)(92).…”

Section: Linear Iga Dermatosismentioning

confidence: 99%

Blistering disorders: diagnosis and treatment

et al. 2003

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Blistering diseases are a heterogeneous group of disorders that can affect either skin and mucous membrane, or both, varying in presentation, clinical course, pathohistology, immunopathology and treatment. Not infrequently the diagnosis is delayed. This can result in severe, and sometimes fatal consequences. Although these diseases are rare, it is very important to make an accurate diagnosis based on a combination of clinical profile and laboratory observations. A brief review is presented of the following bullous diseases: pemphigus, paraneoplastic pemphigus, bullous pemphigoid, cicatricial pemphigoid, epidermolysis bullosa acquisita, dermatitis herpetiformis, linear IgA bullous disease, porphyria cutanea tarda, and subcorneal pustular dermatitis. Their clinical, pathohistologic and immunopathologic features and recommendations for therapy are discussed.

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“…The pathogenesis of LAD is unknown, but is believed to be autoantibody mediated. The onset of LAD is generally idiopathic, but a number of cases have been reported either following drug exposure (vancomycin, 9,11,13,14,16 lithium carbonate, 11 diclophenac, 11 glibenclamide, 11 captopril, 12 piroxicam 15 ) or in association with malignancies 9,10 …”

Section: Discussionmentioning

confidence: 99%

“…Despite all the reports, there has been little progress regarding the aetiology of LAD. Several reports of LAD associated with drug exposure and lymphoproliferative malignancy have appeared 9–16 . Trauma and burns have not previously been associated with LAD, but a triggering effect of trauma has been suggested in some patients with BP 17 …”

Section: Introductionmentioning

confidence: 99%

Burn‐induced linear IgA dermatosis

Girão

Fiadeiro

2000

Acad Dermatol Venereol

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There have been several reports of linear IgA dermatosis (LAD) associated with drug exposure and lymphoproliferative malignancy, but trauma and burns have been suggested only in patients with bullous pemphigoid. We present a case of burn-induced LAD in a 48-year-old caucasian male presenting with a recent history of blistering eruption on the periphery of a cicatricial area caused by boiling methyl alcohol. Clinically, he presented a widespread bullous eruption. The direct immunofluorescence examination of a perilesional biopsy revealed an intense homogeneous linear pattern of IgA deposition consistent with the diagnosis of LAD. The patient responded to therapy with systemic steroids.

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A bullous eruption in an elderly woman. Vancomycin-associated linear IgA dermatosis (LAD)

Cited by 27 publications

References 0 publications

A case of vancomycin-associated linear IgA bullous dermatosis and IgA antibodies to the α3 subunit of laminin-332

A case of vancomycin-associated linear IgA bullous dermatosis and IgA antibodies to the α3 subunit of laminin-332

Blistering disorders: diagnosis and treatment

Burn‐induced linear IgA dermatosis

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