Burn‐induced linear IgA dermatosis

Abstract

There have been several reports of linear IgA dermatosis (LAD) associated with drug exposure and lymphoproliferative malignancy, but trauma and burns have been suggested only in patients with bullous pemphigoid. We present a case of burn-induced LAD in a 48-year-old caucasian male presenting with a recent history of blistering eruption on the periphery of a cicatricial area caused by boiling methyl alcohol. Clinically, he presented a widespread bullous eruption. The direct immunofluorescence examination of a perilesional biopsy revealed an intense homogeneous linear pattern of IgA deposition consistent with the diagnosis of LAD. The patient responded to therapy with systemic steroids.

Drug-Induced Linear IgA Bullous Dermatosis

“…Vancomycin‐induced LABD has been most often reported (24–30, 32), and is the most commonly associated drug as a causative drug for the disorder. Interestingly, some cutaneous disorders, including burns, contact dermatitis, and UV radiation, have been associated with non‐drug related LABD (17, 22, 43–45). The diagnosis of LABD can be made by the linear IgA deposition at BMZ on direct IF.…”

Ultraviolet-induced linear IgA bullous dermatosis: a case report and literature survey

“…Most cases are idiopathic; however, the role of different triggering agents has been well documented, including infections and drugs such as vancomycin and nonsteroidal anti‐inflammatory drugs . In contrast, there are only a few reported cases of LABD provoked by irritant agents, such as ultraviolet (UV) radiation or chemicals …”

Linear IgA dermatosis in an immunosuppressed patient after allogenic bone marrow transplantation

“…Some patients have been reported to develop a vesicular eruption shortly after an irritant dermatitis caused by contact with a detergent containing sodium hypochlorite, or with iodine or tea tree oil 12–14 . LAD may also be triggered by physical trauma, burns or upper respiratory infections 15 . Most authors believe LAD to be autoantibody mediated.…”