A Broad Variety of Antigens Contribute to the Pathogenesis of Atherosclerosis: How to Neutralize Noxious Reactions in the Host

Magrone, Thea; Jirillo, E

doi:10.2174/187153010791213083

Cited by 3 publications

(2 citation statements)

References 153 publications

(174 reference statements)

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“…Use of nutraceuticals to prevent or arrest age-related diseases such as atherosclerosis has become very popular worldwide [64]. In this framework, human milk occupies a prominent position in the diet since neonatal age for its healthy effects.…”

Section: Resultsmentioning

confidence: 99%

Restoration of host–microbiota homeostasis for attaining healthy aging: the role of milk and fermented milk

Jirillo

Magrone³

2011

Mediterr J Nutr Metab

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Intestinal microbiota and gut-associated lymphoreticular tissue are in a dynamic equilibrium, the rupture of which causes a condition of dysbiosis in the host.\ud Among many natural foods, milk, because of its composition, is able to influence the host–microbiota relationship.\ud Donkey’s and goat’s milk represents a good alternative to human milk. Healthy effects of both kinds of milk have been reported in either in vitro or in vivo experiments. When administered to elderly subjects, donkey’s milk increased the release of interleukins 6 and 8, while goat’s milk exerted opposite effects. With special reference to fermented cow’s milk, a symbiotic (Gorbach and Goldin) when administered to another group of elderly people, behaved as donkey’s milk upregulating interleukins 6, 8 and also 1. In conclusion, the ability of milk and fermented milk to modulate the altered immune response in senescence needs to be exploited more for maintaining healthy aging

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Section: Resultsmentioning

confidence: 99%

Restoration of host–microbiota homeostasis for attaining healthy aging: the role of milk and fermented milk

Jirillo

Magrone³

2011

Mediterr J Nutr Metab

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“…On the other hand, excess of certain hypercaloric foods leads to severe consequences in humans such as the dismetabolic syndrome, even including atherosclerosis. In particular, atherosclerosis is a disease where LPS plays a pathogenic role in the progression of several interconnected pathological events within the arterial cell wall [150]. Therefore, the inflammatory status in atherosclerotic patients can be aggravated in the presence of additional antigenic challenges such as in sepsis.…”

Section: Discussionmentioning

confidence: 99%

Microbial Antigenic Pressure and Evolution of the Immune Response: Toward a Better Understanding of the Human Immune System in Health and Disease and Therapeutic Interventions

Magrone¹,

Jirillo²

2010

EMIDDT

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The continuous antigenic triggering has greatly contributed to the evolution of the immune system and, therefore, animals have developed cells able to cope with a broad variety of microbial antigens and or their toxins, e.g., endotoxins. At the same time, intestinal commensals have evolved along with human progress and introduction of new foods, thus empowering both regional and systemic immune response. In this review, some important steps in the evolution of the immune system will be analyzed such as organization of lymphoid organs, formation of germinal centers, leukocyte attraction to tissue function of Toll like receptors and role of antimicrobial peptides. In particular, the major phylogenetic acquisitions of living organisms in the assessment of the immune machinery will be emphasized. Finally, fish will be taken into consideration as animal models of human diseases also in view of drug design strategies. Special attention will be focused on vaccinated salmon and zebrafish models.

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Functional foods and nutraceuticals as therapeutic tools for the treatment of diet-related diseases

Magrone

Heredia

Jirillo

et al. 2013

Can. J. Physiol. Pharmacol.

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In Western societies, the incidence of diet-related diseases is progressively increasing due to greater availability of hypercaloric food and a sedentary lifestyle. Obesity, diabetes, atherosclerosis, and neurodegeneration are major diet-related pathologies that share a common pathogenic denominator of low-grade inflammation. Functional foods and nutraceuticals may represent a novel therapeutic approach to prevent or attenuate diet-related disease in view of their ability to exert anti-inflammatory responses. In particular, activation of intestinal T regulatory cells and homeostatic regulation of the gut microbiota have the potential to reduce low-grade inflammation in diet-related diseases. In this review, clinical applications of polyphenol-rich functional foods and nutraceuticals in postprandial inflammation, obesity, and ageing will be discussed. We have placed special emphasis on polyphenols since they are broadly distributed in plants.

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A Broad Variety of Antigens Contribute to the Pathogenesis of Atherosclerosis: How to Neutralize Noxious Reactions in the Host

Cited by 3 publications

References 153 publications

Restoration of host–microbiota homeostasis for attaining healthy aging: the role of milk and fermented milk

Restoration of host–microbiota homeostasis for attaining healthy aging: the role of milk and fermented milk

Microbial Antigenic Pressure and Evolution of the Immune Response: Toward a Better Understanding of the Human Immune System in Health and Disease and Therapeutic Interventions

Functional foods and nutraceuticals as therapeutic tools for the treatment of diet-related diseases

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