A broad-spectrum organophosphate pesticide O,O-dimethyl O-4-nitrophenyl phosphorothioate (methyl parathion) adversely affects the structure and function of male accessory reproductive organs in the rat

Methyl parathion induces the formation of symplasts by round spermatid fusion and alters the biochemical parameters in the testis

“…or 3.5 mg/kg p.o. for 25 days [3,13,14]. Therefore, the biochemical effects would also be more in the testis after these two treatment schedules.…”

“…as well as p.o. exposures for 25 days [14]. Similarly, MP exhibited a higher degree of toxicity on the testis, especially at the same treatment schedule mentioned above, but also in other treatment schedules [3].…”

“…The testosterone levels increased with concomitant decrease in leutinizing hormone levels, however, the testis weight was decreased and the seminiferous epithelium showed vacuoles, sloughing of immature germ cells, multinucleated cells and tubular atrophy, indicating extensive structural changes [3]. In other words, MP changed the normal structure and function of reproductive organs after neonatal as well as adult exposure, possibly acting as an anti-androgen [3,13,14]. The symplasts are the abnormal giant cells formed in the testis following the chemical exposure.…”

Reproductive and Developmental Toxicity of Insecticides

“…Methyl parathion adversely affect male rat reproductive organs by inducing vacuolization of the epithelium of seminiferous tubules, nuclear pyknosis and brush border disruption in the ductus deferens with the presence of immature cells in the lumen. Also, the activity of acid phosphatase was reduced (Narayana et al, 2006). Methyl Parathion caused significant decrease in the weight of testis, epididymis, seminal vesicle and ventral prostate with marked pathomorphological changes.…”

Organophosphates as Endocrine Disruptors

“…An increase of apoptosis in spermatogonia by the OP was also reported by BustosObregon et al (2001). Methyl parathion adversely affected the structure and function of male accessory reproductive organs in the rat (Narayana et al, 2006). Ray et al (1991Ray et al ( , 1992 reported that quinalphos shows adverse effects on the testis and male accessory glands in rats.…”